Simulation of Closed Timelike Curves in the Framework of an Information-Theoretic Darwinian Approach to Quantum Mechanics

Closed timelike curves (CTCs), non-intuitive theoretical solutions of general relativity field equations can be modelled in quantum mechanics in a way, known as Deutsch-CTCs, to circumvent one of their most paradoxical implications, namely, the so-called grandfather paradox. An outstanding theoretical result of this model is the demonstration that in the presence of a Deutsch-CTC a classical computer would be computationally equivalent to a quantum computer. In the present study, the possible implications of such a striking result for the foundations of quantum mechanics and the connections between classicality and quantumness are explored. To this purpose, a model for fundamental particles that interact in physical space exchanging carriers of momentum and energy is considered. Every particle is then supplemented with an information space in which a probabilistic classical Turing machine is stored. It is analysed whether, through the action of Darwinian evolution, both a classical algorithm coding the rules of quantum mechanics and an anticipation module might plausibly be developed on the information space from initial random behaviour. The simulation of a CTC on the information space of the particle by means of the anticipation module would imply that fundamental particles, which do not possess direct intrinsic quantum features from first principles in this information-theoretic Darwinian approach, could however generate quantum emergent behaviour in real time as a consequence of Darwinian evolution acting on information-theoretic physical systems.

Mutations in artificial self-replicating tiles: A step toward Darwinian evolution

Artificial self-replication and exponential growth holds the promise of gaining a better understanding of fundamental processes in nature but also of evolving new materials and devices with useful properties. A system of DNA origami dimers has been shown to exhibit exponential growth and selection. Here we introduce mutation and growth advantages to study the possibility of Darwinian-like evolution. We seed and grow one dimer species, AB, from A and B monomers that doubles in each cycle. A similar species from C and D monomers can replicate at a controlled growth rate of two or four per cycle but is unseeded. Introducing a small mutation rate so that AB parents infrequently template CD offspring we show experimentally that the CD species can take over the system in approximately six generations in an advantageous environment. This demonstration opens the door to the use of evolution in materials design.

Cancer drivers and clonal dynamics in acute lymphoblastic leukaemia subtypes

To obtain a comprehensive picture of composite genetic driver events and clonal dynamics in subtypes of paediatric acute lymphoblastic leukaemia (ALL) we analysed tumour-normal whole genome sequencing and expression data from 361 newly diagnosed patients. We report the identification of both structural drivers, as well as recurrent non-coding variation in promoters. Additionally we found the transcriptional profile of histone gene cluster 1 and CTCF altered tumours shared hallmarks of hyperdiploid ALL suggesting a ‘hyperdiploid like’ subtype. ALL subtypes are driven by distinct mutational processes with AID mutagenesis being confined to ETV6-RUNX1 tumours. Subclonality is a ubiquitous feature of ALL, consistent with Darwinian evolution driving selection and expansion of tumours. Driver mutations in B-cell developmental genes (IKZF1, PAX5, ZEB2) tend to be clonal and RAS/RTK mutations subclonal. In addition to identifying new avenues for therapeutic exploitation, this analysis highlights that targeted therapies should take into account composite mutational profile and clonality.

Role of environmentally induced epigenetic transgenerational inheritance in evolutionary biology: Unified Evolution Theory

The current evolutionary biology theory primarily involves genetic alterations and random DNA sequence mutations to generate the phenotypic variation required for Darwinian natural selection to act. This neo-Darwinian evolution is termed the Modern Evolution Synthesis and has been the primary paradigm for nearly 100 years. Although environmental factors have a role in neo-Darwinian natural selection, Modern Evolution Synthesis does not consider environment to impact the basic molecular processes involved in evolution. An Extended Evolutionary Synthesis has recently developed that extends the modern synthesis to consider non-genetic processes. Over the past few decades, environmental epigenetics research has been demonstrated to regulate genetic processes and directly generate phenotypic variation independent of genetic sequence alterations. Therefore, the environment can on a molecular level through non-genetic (i.e. epigenetic) mechanisms directly influence phenotypic variation, genetic variation, inheritance and adaptation. This direct action of the environment to alter phenotype that is heritable is a neo-Lamarckian concept that can facilitate neo-Darwinian (i.e. Modern Synthesis) evolution. The integration of genetics, epigenetics, Darwinian theory, Lamarckian concepts, environment, and epigenetic inheritance provides a paradigm shift in evolution theory. The role of environmental-induced epigenetic transgenerational inheritance in evolution is presented to describe a more unified theory of evolutionary biology.

Randomness and Providence: Is God a Bowler or a Curler?

Some theists take God to govern the cosmos by way of intervention. Others deny that God would violate the laws of nature. The distinction is illustrated by contrasting the sports of curling and bowling, which are in turn developed into memorable metaphors for divine providence. The two major scientific challenges to providence—Darwinian evolution and quantum mechanics—are also introduced.

Beyond IIT: (how) can we model the evolution of consciousness?

Tononi et al.'s "integrated information theory" (IIT) postulates rules for assigning measures Phi and qualia types Q of consciousness to classical information networks. We consider whether IIT is compatible with Darwinian evolution. We argue that an IIT-like theory that assigns consciousness to physical systems by relatively simple mathematical rules poses extraordinary ?ne-tuning problems.For example, why, among all possible lawlike theories of consciousness, do we have one that makes us conscious of a high-level narrative of our environment and actions, so accurate that it appears to us to cause our behaviour?We introduce IIT+, a class of extensions of IIT in which Phi and/or Q influence the network dynamics. We argue that IIT+-like theories, unlike IIT-like theories, offer at least partial explanations of how some key features of consciousness evolved. We conclude that if one takes seriously Darwinian evolution and the case for an IIT-like theory, one has to take seriously the case for an IIT+-like theory.

Evolutionary transition from a single RNA replicator to a multiple replicator network

In prebiotic evolution, self-replicating molecules are believed to have evolved into complex living systems by expanding their information and functions open-endedly. Theoretically, such evolutionary complexification could occur through successive appearance of novel replicators that interact with one another to form replication networks. Here we performed long-term evolution experiments using an RNA that replicates by a self-encoded RNA replicase. The RNA diversified into multiple coexisting host and parasite lineages, whose frequencies in the population initially fluctuated and gradually stabilized. The final population, comprising five RNA lineages, forms a replicator network with diverse interactions, including cooperation to help the replication of all other members. These results support the capability of molecular replicators to spontaneously develop complexity through Darwinian evolution, a critical step for the emergence of life.

Alister Hardy: A Naturalist of the Spiritual Realm

Alister Hardy was one of the pioneers of the scientific study of spiritual experiences (SE); however, his work and insights have not received the attention they deserve. This paper, based on an in-depth analysis of Hardy’s own writings, presents his main methodological and epistemological contributions for advancing the investigation of SE. Hardy’s main epistemological propositions were as follows: the transcendent as the core of spirituality and SE as a major source of R/S beliefs; a nondogmatic approach, acknowledging that Darwinian evolution does not imply materialism and that mind is not reducible to matter; and a call for studies of psychic experiences and considering an expanded naturalism, including the “para-physical”, that could lead to a perennial philosophy and a natural theology. His methods focused on phenomenological classification and the development of a natural history of SE based on studies with proper ecological validity on the experimental and the experiential, mixing large surveys of the general population with in-depth qualitative studies of the most prominent cases. In addition, it would be worth investigating developments of SE throughout a person’s life. Bringing back Hardy’s contributions will foster a better understanding of the history of the scientific study of SE and provide key insights for moving it forward.