Effect of Local Urokinase on Arterial Occlusion of Lower Limbs

1981 ◽  
Vol 45 (03) ◽  
pp. 230-232 ◽  
Author(s):  
J-N Fiessinger ◽  
M Aiach ◽  
L Capron ◽  
M Devanlay ◽  
M Vayssairat ◽  
...  
Keyword(s):  
Thrombolytic Therapy ◽  
Arterial Occlusion ◽  
Lower Limbs ◽  
Amputation Rate ◽  
Biological Study ◽  
The Difference ◽  
Local Thrombolytic Therapy ◽  
Severe Ischemia

SummarySixty nine patients were treated with local intra-arterial urokinase (37,500 U/CTA. hr-1) for recent severe ischemia of lower limbs: 27 (40%) ultimately required amputation. The difference of amputation rate between the groups with and without thrombolysis was not significant (33% v. 42%). A biological study in 6 patients showed that local arterial plasminemia occurred in only 1 patient. Local urokinase does not strongly stimulate “endogenous” thrombolysis and enhances “exogenous” thrombolysis only very inconstantly. A better adaptation of urokinase dosage or the use of an agent with a higher affinity for fibrin might improve the efficiency of local thrombolytic therapy.

scholarly journals Nails Involvement in Winiwarter-Buerger Disease

2021 ◽  
pp. 1-4
Author(s):  
Michela V.R. Starace ◽  
Aurora Alessandrini ◽  
Antonella Tosti ◽  
Bianca Maria Piraccini
Keyword(s):  
Inflammatory Process ◽  
Arterial Occlusion ◽  
Signs And Symptoms ◽  
Lower Limbs ◽  
Thromboangiitis Obliterans ◽  
Medium Size ◽  
Case Presentation ◽  
Bed Erosion ◽  
Arteries And Veins ◽  
Severe Ischemia

<b><i>Introduction:</i></b> Buerger disease, or thromboangiitis obliterans, is an inflammatory and occlusive process involving small and medium size arteries and veins, which generally affects the lower limbs of young adult male with the habit of smoking. <b><i>Case Presentation:</i></b> This paper reports 2 patients who developed nail lesions as the first sign of Buerger disease. <b><i>Conclusion:</i></b> Signs and symptoms of Buerger’s disease are secondary to the inflammatory process and arterial occlusion which results in severe ischemia. Involvement of nails is not common, but we found 2 different clinical features which have not been previously reported in the literature: chronic paronychia, and proximal leukonychia or onycholysis and nail bed erosion.

Thrombolysis in Arterial Occlusion

1999 ◽  
Vol 82 (S 01) ◽  
pp. 109-111 ◽  
Author(s):  
Raymond Verhaeghe
Keyword(s):  
Clinical Practice ◽  
Thrombolytic Therapy ◽  
Hemorrhagic Stroke ◽  
Surgical Intervention ◽  
Bypass Graft ◽  
Surgical Techniques ◽  
Arterial Occlusion ◽  
Second Step ◽  
Severe Bleeding ◽  
Initial Management

SummaryIntra-arterial thrombolytic therapy has replaced systemic intravenous infusion of thrombolytic agents as a treatment modality for arterial occlusion in the limbs. Several catheter-guided techniques and various infusion methods and schemes have been developed. At present there is no scientific proof of definite superiority of any agent in terms of efficacy or safety but clinical practice favours the use of urokinase or alteplase. Studies which compared thrombolysis to surgical intervention suggest that thrombolytic therapy is an appropriate initial management in patients with acute occlusion of a native leg artery or a bypass graft. Underlying causative lesions are treated in a second step by endovascular or open surgical techniques. Severe bleeding is the most feared complication: the risk of hemorrhagic stroke is 1-2%.

Abdominal Pain Secondary to Pylephlebitis: An Uncommon Disease of the Portal Venous System, Treated with Local Thrombolytic Therapy

2005 ◽  
Vol 50 (5) ◽  
pp. 983-987 ◽  
Author(s):  
Rathnakara Sherigar ◽  
Khalil A. Amir ◽  
Ravi K. Bobba ◽  
Edward L. Arsura ◽  
Narain Srinivas
Keyword(s):  
Abdominal Pain ◽  
Thrombolytic Therapy ◽  
Venous System ◽  
Portal Venous System ◽  
Uncommon Disease ◽  
Local Thrombolytic Therapy

Use of pulse pressure method for estimating total arterial compliance in vivo

1999 ◽  
Vol 276 (2) ◽  
pp. H424-H428 ◽  
Author(s):  
N. Stergiopulos ◽  
P. Segers ◽  
N. Westerhof
Keyword(s):  
Pulse Pressure ◽  
Diastolic Pressure ◽  
Arterial Compliance ◽  
Aortic Pressure ◽  
Lower Limbs ◽  
Pressure Method ◽  
Total Arterial Compliance ◽  
The Difference ◽  
Pulse Pressure Method

We determined total arterial compliance from pressure and flow in the ascending aorta of seven anesthetized dogs using the pulse pressure method (PPM) and the decay time method (DTM). Compliance was determined under control and during occlusion of the aorta at four different locations (iliac, renal, diaphragm, and proximal descending thoracic aorta). Compliance of PPM gave consistently lower values (0.893 ± 0.015) compared with the compliance of DTM (means ± SE; r = 0.989). The lower compliance estimates by the PPM can be attributed to the difference in mean pressures at which compliance is determined (mean pressure, 81.0 ± 3.6 mmHg; mean diastolic pressure, over which the DTM applies, 67.0 ± 3.6 mmHg). Total arterial compliance under control conditions was 0.169 ± 0.007 ml/mmHg. Compliance of the proximal aorta, obtained during occlusion of the proximal descending aorta, was 0.100 ± 0.007 ml/mmHg. Mean aortic pressure was 80.4 ± 3.6 mmHg during control and 102 ± 7.7 mmHg during proximal descending aortic occlusion. From these results and assuming that upper limbs and the head contribute as little as the lower limbs, we conclude that 60% of total arterial compliance resides in the proximal aorta. When we take into account the inverse relationship between pressure and compliance, the contribution of the proximal aorta to the total arterial compliance is even more significant.

scholarly journals Manfaat Rendaman Air Hangat dan Garam dalam Menurunkan Derajat Edema Kaki Ibu Hamil Trimester III

2020 ◽  
Vol 7 (2) ◽  
pp. 76
Author(s):  
Sawitry Sawitry ◽  
Fitria Hikmatul Ulya ◽  
Elisabet Jemsi Adepatiloy
Keyword(s):  
Pregnant Women ◽  
Quantitative Research ◽  
Mean Value ◽  
Lower Limbs ◽  
Wilcoxon Test ◽  
Warm Water ◽  
Third Trimester ◽  
Post Test ◽  
The Difference ◽  
Leg Edema

ABSTRAK Edema kaki terjadi hampir 80% dari semua kehamilan dan dapat menimbulkan ketidaknyamanan selama kehamilan seperti nyeri, merasa berat, kram pada malam hari, penebalan kulit, dan pigmentasi. Salah satu intervensi non farmakologis untuk mengurangi edema adalah rendaman air hangat dan garam yang merupakan intervensi untuk menghilangkan edema pada ekstremitas bawah  selama kehamilan. Menganalisis  pengaruh rendaman air hangat dan garam  terhadap edema kaki ibu hamil trimester III. Penelitian kuantitatif dengan metode quasy eksperimental one group pre test post test desaign. Sampel penelitian sebanyak 16 ibu hamil Trimester III dengan teknik accidental sampling. Analisis data menggunakan uji Wilcoxon. Terjadi penurunan tingkat edema kaki pada ibu hamil dengan selisih nilai tengah edema kaki sebelum 4,00 dan setelah perlakuan sebesar 0,00  .Uji Wilcoxon menunjukkan ρ value 0,000. Ada pengaruh rendaman air hangat dan garam  terhadap edema kaki ibu hamil trimester III. Kata Kunci : rendaman air hangat dan garam; edema; tungkai bawah ; ibu hamil.  THE EFFECT OF WARM WATER AND SALT IMMERSION IN DECLINING LEG EDEMA OF THIRD TRIMESTER PREGNANT WOMEN  ABSTRACT Edema of the legs occurs in almost 80% of all pregnancies and can cause discomfort during pregnancy such as pain, feeling heavy, cramps at night, skin thickening, and pigmentation. One of the non-pharmacological interventions to reduce edema is soaking in warm water and salt which is an intervention to relieve edema in the lower extremities during pregnancy. This study was to determine the effect of warm water and salt immersion in declining leg edema of third trimester pregnant women. This quantitative research used quasy experimental method one group pre test post test desaign. The total samples were 16 respondents with purposive sampling and random sampling techniques. Data analysis used the Wilcoxon test. The difference in the mean value of leg edema before 4.00 and after treatment was 0.00. The Wilcoxon test showed ρ value of 0.000. There is an effect of warm water and salt immersion on leg edema of third trimester pregnant women.   Keywords: warm water and salt soaking; edema; lower limbs; pregnant mother

scholarly journals Local Thrombolytic Therapy for Primary Axillosubclavian Vein Thrombosis

2010 ◽  
Vol 1 (1) ◽  
pp. 1-2
Author(s):  
Isabella Maund ◽  
Edward Banham-Hall ◽  
Robert Mallinson
Keyword(s):  
Thrombolytic Therapy ◽  
Vein Thrombosis ◽  
Local Thrombolytic Therapy

CHANGES IN THE FLEXOR AND EXTENSOR MUSCLES AT DIFFERENT SPEEDS

2021 ◽  
Vol 27 (7) ◽  
pp. 686-688
Author(s):  
Rui Ma ◽  
Wenyan Li
Keyword(s):  
Knee Joint ◽  
Peak Torque ◽  
Muscle Group ◽  
Lower Limbs ◽  
Flexor Muscle ◽  
Level Of Evidence ◽  
Isokinetic Test ◽  
Extensor Muscles ◽  
Test Velocity ◽  
The Difference

ABSTRACT Introduction: Centrifugal strength is an important element for strength quality. Developing muscle centrifugal strength can effectively increase the stability of lower limbs and reduce the risk of injury. Objective: To explore the characteristics of contractile force of flexor ahods in strength training and rehabilitation training, and the extensor muscles of the knee joint in athletes with different speeds of centripetal force. Methods: The knee joint muscle group of 8 first-level male high jumpers and 8 second-level male high jumpers were tested by isokinetic centrifugal contraction; the angular test velocity was 60 °/s, 120 °/s, 240 °/s, and the indexes included peak torque, relative peak torque (peak torque/body weight), and the peak torque flexural extension ratio. Results: With the centrifugal contraction of the knee joint muscle group (P < 0.05), the second-level high jumpers should increase the ability of the knee flexor muscle group of the take-off leg. In the case of constant velocity centrifugal contraction (P < 0.01), taking off time must be reduced, that is, taking off speed must be accelerated. Conclusions: The difference in the knee joint muscle isokinetic test results is one of the reasons for the difference in knee joint flexor and extensor muscle contractility under the different speed forces of high jumpers. Level of evidence II; Therapeutic studies - investigation of treatment results.

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