Antithrombin III, the Major Modulator of Intravascular Coagulation, Is Synthesized by Human Endothelial Cells
1981 ◽
Vol 46
(02)
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pp. 504-506
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Keyword(s):
SummaryHuman endothelial cells in culture is shown to synthesize antithrombin III (At-III). The endothelial cell At-III(EC-At-III) consists of a small fraction similar to plasma At-III and a larger fraction with decreased heparin-binding as tested by crossed immunoelectrophoresis. However, both the anti-Xa and thrombin-neutralizing activities of the EC-At-III were rapid and active even in the absence of added heparin. It is concluded that the major portion was probably bound to endogenous heparin-like substance, thus accounting for its decreased exogenous heparin binding. The presence of At-III and other antithrombotic factors in the vascular endothelium offer protection against thrombosis and possibly atherosclerosis.
1995 ◽
Vol 74
(8)
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pp. 667-669
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1992 ◽
Vol 267
(4)
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pp. 2264-2268
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1987 ◽
Vol 57
(01)
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pp. 087-091
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1979 ◽
Vol 42
(05)
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pp. 1434-1445
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1979 ◽
Vol 15
(1-2)
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pp. 209-213
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Keyword(s):
1980 ◽
Vol 44
(02)
◽
pp. 092-095
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