Evaluation of the Efficacy of Enoxaparin in the Neonatal Intensive Care Unit

Author(s):  
Diane Song ◽  
Jacqueline Magers ◽  
Mahmoud Abdel-Rasoul ◽  
Pavel Prusakov

Abstract Objective This article evaluates the efficacy of enoxaparin when targeting anti-factor Xa levels of 0.5 to 1 units per milliliter in the neonatal intensive care unit. Study Design This is a retrospective chart review of 45 neonates receiving enoxaparin for the treatment of venous thromboembolism. Enoxaparin dosing and corresponding anti-factor Xa levels were collected. Time to resolution of clot was confirmed by imaging and compared between clots in various locations. Results The median time to clot resolution was 76 days (interquartile range 40–91 days). Clot location, postnatal age, and sex at the clot onset were significantly associated with time to clot resolution in a multivariable Cox model (p-value: 0.03, 0.03, and < 0.01, respectively). Of the 54 patients analyzed for safety, 5 patients (9.3%) experienced bleeding events resulting in the discontinuation of enoxaparin. Conclusion Based on our findings, 50% of all patients evaluated, regardless of thrombus location, achieved resolution within the first 76 days of therapy. Clots located in the extremities tended to resolve sooner, hence earlier reimaging should be considered.

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S713-S713
Author(s):  
Carlo Fopiano Palacios ◽  
Eric Lemmon ◽  
James Campbell

Abstract Background Patients in the neonatal intensive care unit (NICU) often develop fevers during their inpatient stay. Many neonates are empirically started on antibiotics due to their fragile clinical status. We sought to evaluate whether the respiratory viral panel (RVP) PCR test is associated with use of antibiotics in patients who develop a fever in the NICU. Methods We conducted a retrospective chart review on patients admitted to the Level 4 NICU of the University of Maryland Medical Center from November 2015 to June 2018. We included all neonates who developed a fever 48 hours into their admission. We collected demographic information and data on length of stay, fever work-up and diagnostics (including labs, cultures, RVP), and antibiotic use. Descriptive statistics, Fisher exact test, linear regression, and Welch’s ANOVA were performed. Results Among 347 fever episodes, the mean age of neonates was 72.8 ± 21.6 days, and 45.2% were female. Out of 30 total RVP samples analyzed, 2 were positive (6.7%). The most common causes of fever were post-procedural (5.7%), pneumonia (4.8%), urinary tract infection (3.5%), meningitis (2.6%), bacteremia (2.3%), or due to a viral infection (2.0%). Antibiotics were started in 208 patients (60%), while 61 neonates (17.6%) were already on antibiotics. The mean length of antibiotics was 7.5 ± 0.5 days. Neonates were more likely to get started on antibiotics if they had a negative RVP compared to those without a negative RVP (89% vs. 11%, p-value &lt; 0.0001). Patients with a positive RVP had a decreased length of stay compared to those without a positive RVP (30.3 ± 8.7 vs. 96.8 ± 71.3, p-value 0.01). On multivariate linear regression, a positive RVP was not associated with length of stay. Conclusion Neonates with a negative respiratory viral PCR test were more likely to be started on antibiotics for fevers. Respiratory viral PCR testing can be used as a tool to promote antibiotic stewardship in the NICU. Disclosures All Authors: No reported disclosures


Author(s):  
Maura Harkin ◽  
Peter N. Johnson ◽  
Stephen B. Neely ◽  
Lauren White ◽  
Jamie L. Miller

Objective Although thiazide diuretics are commonly used in the neonatal intensive care unit (NICU), the risk of thiazide-induced hyponatremia in infants has not been well documented. The primary objective of this study was to determine the frequency and severity of hyponatremia in neonates and infants receiving enteral chlorothiazide. Secondary objectives included identifying: (1) percent change in serum sodium from before chlorothiazide initiation to nadir, (2) time to reach nadir serum sodium concentration, and (3) percentage of patients on chlorothiazide receiving sodium supplementation. Study Design This was a retrospective cohort study of NICU patients admitted between July 1, 2014 and July 31, 2019 who received ≥1 dose of enteral chlorothiazide. Mild, moderate, and severe hyponatremia were defined as serum sodium of 130 to 134 mEq/L, 120 to 129 mEq/L, and less than 120 mEq/L, respectively. Data including serum electrolytes, chlorothiazide dosing, and sodium supplementation were collected for the first 2 weeks of therapy. Descriptive and inferential statistics were performed in SAS software, Version 9.4. Results One hundred and seven patients, receiving 127 chlorothiazide courses, were included. The median gestational age at birth and postmenstrual age at initiation were 26.0 and 35.9 weeks, respectively. The overall frequency of hyponatremia was 35.4% (45/127 courses). Mild, moderate, and severe hyponatremia were reported in 27 (21.3%), 16 (12.6%), and 2 (1.6%) courses. The median percent decrease in serum sodium from baseline to nadir was 2.9%, and the median time to nadir sodium was 5 days. Enteral sodium supplements were administered in 52 (40.9%) courses. Sixteen courses (12.6%) were discontinued within the first 14 days of therapy due to hyponatremia. Conclusion Hyponatremia occurred in over 35% of courses of enteral chlorothiazide in neonates and infants. Given the high frequency of hyponatremia, serum sodium should be monitored closely in infants receiving chlorothiazide. Providers should consider early initiation of sodium supplements if warranted. Key Points


2015 ◽  
Vol 10 (2) ◽  
pp. 93
Author(s):  
Anita Rahmawati ◽  
Endah Marianingsih Theresia ◽  
Yuliasti Eka Purnamaningrum

AbstrakKangaroo mother care (KMC) merupakan metode merawat bayi beratbadan lahir rendah (BBLR). Beberapa intervensi perawatan di neonatal intensive care unit seperti pijat bayi, KMC, dan mendengarkan musik bermanfaat untuk pertumbuhan bayi berupa respons fisiologis BBLR dan mengurangi lama rawat. Penelitian ini bertujuan untuk mengetahui manfaat musik keroncong terhadap respons BBLR selama KMC dan lama rawat. Rancangan penelitian adalah quasi eksperimental dengan pretest dan posttest dengan desain grup kontrol. Pada Juli - September 2014 populasi penelitian adalah ibu dan bayi BBLR yang melaksanakan KMC. Pengambilan sampel dengan purposive sampling sebanyak 60 bayi. Kriteria inklusi bayi BBLR yang ditetapkan adalah berat badan bayi 1.500 – 2.499 gram, tanpa memandang usia kehamilan, bayi mampu menghisap walaupun masih lemah, tidak mengalami kesulitan pernapasan. Kriteriaeksklusi adalah bayi dengan kelainan kongenital, gejala sepsis, dan bayi yang dilakukan foto terapi. Uji statistik menggunakan uji-t berpasangan, ujit independen dengan nilai p < 0,05 dan CI 95%. Setelah perlakuan hari ketiga, terjadi penurunan nadi pada bayi dengan BBLR 8,13 kali/menit (nilai p = 0,000), respirasi penurunannya 2,36 kali/menit (nilai p = 0,000). Rerata lama rawat bayi pada kelompok perlakuan adalah 8,57 hari, sedangkan kelompok kontrol adalah 11,87 hari (nilai p = 0,038). Suhu hasilnya tidak bermakna (nilai p > 0,05). Dapat disimpulkan bahwa musik keroncong berpengaruh terhadap penurunan nadi, respirasi selama KMC, dan lama rawat bayi.AbstractKangaroo Mother Care (KMC) is nursing care method for low birthweight(LBW) infants. Some care interventions in neonatal intensive care unit, such as infant massage, KMC and listening to music have advantage for infant growth in form of physiological responses and reduce LBW infant-nursing length. This study aimed to determine advantage of keroncong music toward LBW infant’s response during KMC and nursing length. The study design was quasi experimental using pretest and posttest using control group design. Population was mothers and LBW infants implementing KMC. Samples were 60 infants taken by purposive sampling. Inclusion criteria determined for LBW infants were having weight 1,500 – 2,499 gram, without considering pregnancy age, having ability to suckle though still weak, not suffering breathing distress. Meanwhile, exclusion criteria were infants with congenital disorder, sepsis symptoms and infants during therapy photo. Statistical test used paired t-test, independent t-test with p value < 0.05 and confidence interval (CI) 95%. After third day of treatment, LBW pulse decreased 8.13 times/minute (p value = 0.000), respiration decreased 2.36 times/minute (p value = 0.000). Nursing length mean on the treatment group was 8.57 days, while the control group was 11.87 days (p value = 0.038). Temperature result was insignificant (p value > 0.05). In conclusion, keroncong music influences on decrease of pulse, respiration during KMC and length of infant nursing.


PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0242025
Author(s):  
Lemi Belay Tolu ◽  
Malede Birara ◽  
Tesfalem Teshome ◽  
Garumma Tolu Feyissa

Objective To determine the perinatal outcome of labouring mothers with meconium-stained amniotic fluid (MSAF) compared with clear amniotic fluid at teaching referral hospital in urban Ethiopia. Methods A prospective cohort study was conducted among labouring mothers with meconium-stained amniotic fluid from July 1 to December 30, 2019. Data was collected with pretested structured questionnaires. A Chi-square test used to check statistical associations between variables. Those variables with a p-value of less than 0.05 were selected for cross-tabulation and binary logistic regression. P-value set at 0.05, and 95% CI was used to determine the significance of the association. Relative risk was used to determine the strength and direction of the association. Result Among 438 participants, there where 75(52.1%) primigravida in a stained fluid group compared to112 (38.5%) of the non-stained fluid group. Labour was induced in 25 (17.4%) of the stained fluid group compared to 25(8.6%) of a non-stained fluid group and has a statistically significant association with meconium staining. The stained fluid group was twice more likely to undergo operative delivery compared with a non-stained fluid group. There were more low Apgar scores at birth (36.8% versus 13.2%), birth asphyxias (9% versus 2.4%), neonatal sepsis (1% versus 5.6%), neonatal death (1% versus 9%), and increased admissions to neonatal intensive care unit (6.2% versus 21.5%) among the meconium-stained group as compared to the non-stained group. Meconium aspiration syndrome was seen in 9(6.3%) of the stained fluid group. Conclusion Meconium-stained amniotic fluid is associated with increased frequency of operative delivery, birth asphyxia, neonatal sepsis, and neonatal intensive care unit admissions compared to clear amniotic fluid.


Author(s):  
Rishika P. Sakaria ◽  
Parul G. Zaveri

Objective Neonatal gastric perforations (NGPs) are rare and account for 7 to 12% of all gastrointestinal perforations in the neonatal period. The etiology and prognostic factors associated with NGP remain unclear. The aim of this study is to review the cases of NGP in our neonatal intensive care unit (NICU) in the past 14 years and describe the risk factors, clinical presentation, and outcomes associated with it. Study Design A retrospective chart review of neonates with gastric perforation admitted to the NICU between June 2006 and December 2020 was performed. Data regarding their antenatal and neonatal characteristics, laboratory and radiological results, intra-operative findings, hospital course, and outcomes were recorded. Results We identified 350 patients with gastrointestinal perforation at our center during the study period of which 14 (4%; nine males and five females) patients were diagnosed with NGP during surgery. A total of 71% neonates were born preterm (range: 24–39 weeks, median: 34 weeks). Two neonates (14%) were SGA. Only one neonate received cardiopulmonary resuscitation at birth. In all neonates, except two, perforation occurred within the first 10 days of life (median: 4 days, range: 1–22 days). In total, 79% infants received feeds prior to perforation. Ten neonates had a feeding tube, and one neonate had a gastrostomy tube placed prior to perforation. Abdominal distension and pneumoperitoneum were present in all neonates. Majority of the babies had metabolic acidosis (64%) and elevated C-reactive protein (79%). Most (86%) neonates received surgical intervention within 12 hours. Overall survival in our study was 93%. Conclusion NGP is a rare entity seen mostly in preterm infants within the first 10 days of life. Clinical presentation is similar to perforation anywhere along the gastrointestinal tract and definite diagnosis requires exploratory laparotomy. With prompt recognition and surgical intervention, the overall mortality related to neonatal gastric perforation is low. Key Points


2021 ◽  
Vol 8 (4) ◽  
pp. 721
Author(s):  
Shwetal M. Bhatt ◽  
Khushboo N. Mehta ◽  
Ankita Maheshwari ◽  
Priyanka C. Parmar

Background: Kangaroo mother care (KMC) is routinely practiced in post-natal wards for care of stable low birth weight (LBW) infants. Objectives of the study were conducted to emphasize on the role of KMC in vitals stabilization and weight gain in LBW babies inside neonatal intensive care unit (NICU).Methods: Cross-sectional analytical quantitative study.Results: A total of 80 babies (48 males and 32 females) were enrolled and given KMC inside NICU. Mean birth weight was 1330 grams. Mean gestational age was 33 weeks (range 30-38 weeks). KMC was initiated within 72 hours of life in majority of babies (71%). Though 65% of them required oxygen support via prongs, KMC was started in them, with monitoring of vitals. No episode of apnea was observed during KMC sessions. Mean duration of KMC was 6 days (3-14 days). Heart rate dropped by 3-4 beats per minute (150+2.12 to 146+1.63, Respiratory rate decreased from 53+3.9 to 49+2.7, Oxygen saturation improved by 2-3% (93+0.42 to 96+0.71). Temperature rose from 36.78+0.01 to 37.07+0.02. P value for all vitals was 0.0001, which is considered significant (<0.05). Average weight gain was 76 grams during the average 6 days of KMC inside NICU, (p value=0.0001).  Conclusions: KMC was found to be effective for stabilization of vitals in NICU, early initiation and upgradation of feeding, early achievement of weight gain pattern, and early shift to postnatal ward by mother’s side. Also, no adverse effects were noted on the babies.


2021 ◽  
Vol 8 (2) ◽  
pp. 038-044
Author(s):  
Ida Ayu Agung Wijayanti ◽  
Putu Junara Putra ◽  
I Made Kardana ◽  
I Wayan Dharma Artana ◽  
Made Sukmawati

Neonatal mortality is topic of concern for many medical faculties. Recently Score for Neonatal Acute Physiology with Perinatal Extension-II (SNAPPE-II) is used to predict the mortality and morbidity of neonates in neonatal intensive care unit (NICU). This study aimed to find the association of mortality and morbidity among neonates using SNAPPE-II score in NICU of Sanglah Hospital with cross-sectional design. All newborns admitted in NICU within 48 hours of birth since January - December 2020 were recruited as sample and assessed by using SNAPPE-II. Statistical analysis was performed by using Chi-square test and Mann–Whitney U test. Eighty-three newborns fulfilled inclusion criteria. In the mortality group, 75.6% had SNAPPE score ≥ 37 and 24% had SNAPPE score <37. SNAPPE-II score ≥ 37 showed an association with mortality group in NICU (p-value 0.000). Moreover, subgroup analyst of neonatal outcome in survived group related to SNAPPE-II score showed significant different in length of stay (P=0.033), ventilator usage (P=0.017) and duration of antibiotic usage (P=0.049). The Score for Neonatal Acute Physiology Perinatal Extension II (SNAPPE-II) is a useful tool to assess severity of illness and mortality. SNAPPE-II score > 37 is associated with neonatal mortality. The high SNAPPE-II score in the survived group also affects length of stay in NICU, ventilator and antibiotic usage. These findings imply that SNAPPE-II can be applied routinely in NICU to know the most critical newborn for prioritizing the management of care and for counselling the parents.


2017 ◽  
Vol 26 (01) ◽  
pp. 206-213
Author(s):  
Kimberly Ernst

Summary Objective: To determine if an electronic alert improves 2 month immunization rates in infants remaining hospitalized in the neonatal intensive care unit. Methods: Institutional Review Board-approved retrospective chart review of 261 infants with birth weights <2 kg and still hospitalized at58 days. Charts were reviewed between 2009 and 2013, before and after the 2011 electronic alert was instituted in the electronic medical record from days 56 to 67 to remind providers that immunizations were due. Order and administration dates of two-month vaccine components (Diphtheria, Haemophilus influenza B, Hepatitis B Pertussis, Pneumococcal, Polio, Tetanus) were determined, and infants were considered fully immunized, partially immunized, or unimmunized by day 90 or discharge, whichever came first. Results: After the alert, the timing of vaccine orders decreased from day 67 to day 61 (p<0.0001) and vaccine administration decreased from day 71 to day 64 (p<0.0001). Missing vaccine orders decreased from 14% [17/121] to 3% [4/140] (p=0.001) with missing administrations decreasing from 21% [26/121] to 4% [6/140] (p<0.0001). Fully immunized rates increased from 71% [86/121] to 94% [132/140] (p<0.0001). Conclusions: A significant improvement in immunization rates in two-month-old infants in the neonatal intensive care unit occurred by 90 days after implementing an alert in the electronic medical record.


2011 ◽  
Vol 02 (03) ◽  
pp. 384-394 ◽  
Author(s):  
TA. Stavroudis ◽  
RE. Miller ◽  
HP. Lehmann ◽  
CU. Lehmann ◽  
L. Samal

Summary Background: A computerized laboratory result paging system (LRPS) that alerts providers about abnormal results (“push”) may improve upon active laboratory result review (“pull”). However, implementing such a system in the intensive care setting may be hindered by low signal-to-noise ratio, which may lead to alert fatigue. Objective: To evaluate the impact of an LRPS in a Neonatal Intensive Care Unit. Methods: Utilizing paper chart review, we tallied provider orders following an abnormal laboratory result before and after implementation of an LRPS. Orders were compared with a predefined set of appropriate orders for such an abnormal result. The likelihood of a provider response in the post-implementation period as compared to the pre-implementation period was analyzed using logistic regression. The provider responses were analyzed using logistic regression to control for potential confounders. Results: The likelihood of a provider response to an abnormal laboratory result did not change significantly after implementation of an LRPS. (Odds Ratio 0.90, 95% CI 0.63–1.30, p-value 0.58) However, when providers did respond to an alert, the type of response was different. The proportion of repeat laboratory tests increased. (26/378 vs. 7/278, p-value = 0.02) Conclusion: Although the laboratory result pager altered healthcare provider behavior in the Neonatal Intensive Care Unit, it did not increase the overall likelihood of provider response.


2021 ◽  
Author(s):  
Qurat-Ul-Ain Siddique ◽  
ABID JAMALI ◽  
Sanober Fatima ◽  
Jai Parkash

Abstract INTRODUCTION:: Approximately 20 to 30% of all anomalies identified in the prenatal period are congenital anomalies of the kidney and urinary tract (CAKUT). Widespread antenatal screening has resulted in increased detection of anomalies of the kidneys and urinary tract. There are limited studies on the postnatal confirmation of these antenatally detected renal malformations. Moreover, there is no local data available in this regard. So, we conducted the study so that we can obtain local data as well as we can plan management and prevention protocols for such chronically, and sometimes critically, ill neonates. MATERIALS AND METHODS:: It was a cross-sectional study conducted at the neonatal intensive care unit (NICU) at the National Institute of Child Health, Karachi during 2017-2018. The sample size was 100 cases. The sampling technique was non-probability consecutive sampling. All neonates aged 1-28 days of either gender admitted in NICU with antenatal diagnosis of congenital renal anomalies on anomaly scan were included in the study. Preterm neonates (gestational age below 34 weeks) and neonates having siblings with similar congenital problems were excluded. RESULTS:: The mean age of the neonates in our study was 10.17 ±9.30 days and the mean gestational age at birth was 36.65 ±1.16 weeks. The majority of the neonates, that is 65%, were males while 35% were females. Sixty-six per cent (66%) neonates were ≤10 days of age while 34% were >10 days of age. Fifty five% of the neonates were ≤36 weeks of gestation at birth while 45% were >36 weeks of gestation at birth. Frequency of postnatally confirmed congenital renal malformation was observed in 78 (78%) neonates. Neonates whose age at presentation was >10 days were slightly more likely to have confirmed congenital renal malformation as compared to neonates with ≤10 days of age, which is 85.3 % vs 74.2 % (p-value 0.206). Males and females were found to have almost equal postnatally confirmed congenital renal malformations (78.5 % in males and 77.1% in females) (p-value 0.879). Postnatally confirmed congenital renal malformations were observed more commonly in neonates who were >36 weeks of gestational age (80%) as compared to those ≤36 weeks of gestational age (76.4%) (p-value 0.662). CONCLUSION::The frequency of confirmed congenital renal malformation was found higher in neonates presenting with antenatal diagnosis of renal anomalies presenting in the neonatal intensive care unit.


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