ROLE OF MATERNAL ERYTHROCYTE ARGINASE ACTIVITY IN PREGNANCY – A PILOT STUDY

Abstract Introduction Arginase is an urea cycle enzyme which catalyzes the cleavage of L arginine to L- ornithine and urea. It is expressed in liver, erythrocyte, brain, kidney, mammary gland and intestine. The arginase activity detected in nonhepatic tissues that lacka complete set of urea cycle enzymes is thought to provide ornithine, the biosynthetic precursor of proline, an important constituent of collagen, andthe polyamines, which are important for cell proliferation. Aim and objectives In the current study arginase level in maternal erythrocytes were determined to ascertain any possible role in pregnancy. Study design The study group comprised of total 45 subjects including twenty non – pregnant women (mean age 31.0 ± 6.0 years) and twenty five pregnant women (mean age 29.6 ± 6.1 years) of gestational age between 28 – 38 weeks. Results We found a significant increase in the level of maternal erythrocyte arginase (p 0.05) in pregnant women when compared to non – pregnant women. Conclusion Our study suggests that the increased maternal erythrocyte arginase activity may have a role in fetal growth and development.

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Effect of hypophysectomy on urea cycle enzyme adaptations

Life Sciences ◽

10.1016/0024-3205(65)90285-7 ◽

1965 ◽

Vol 4 (8) ◽

pp. 899-903 ◽

Cited By ~ 3

Author(s):

R.A. Freedland

Keyword(s):

Urea Cycle ◽

Cycle Enzyme ◽

Urea Cycle Enzyme

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Transient hyperammonaemia in an adult German shepherd dog : case report

Journal of the South African Veterinary Association ◽

10.4102/jsava.v68i2.873 ◽

1997 ◽

Vol 68 (2) ◽

Cited By ~ 3

Author(s):

R.G. Lobetti ◽

D.B. Miller ◽

T. Dippenaar

Keyword(s):

Case Report ◽

Liver Disease ◽

Urinary Tract ◽

Drug Therapy ◽

Urea Cycle ◽

Urinary Tract Obstruction ◽

German Shepherd ◽

Cycle Enzyme ◽

German Shepherd Dog ◽

Urea Cycle Enzyme

A 3-year-old male German shepherd dog was presented with severe generalised seizures. The dog was protein-intolerant and showed severe hyperammonaemia on ammonia stimulation. The hyperammonaemic state was present for at least 6 weeks and then spontaneously resolved. No obvious cause (liver disease, portocaval shunts, urea cycle enzyme deficiencies, drug therapy or urinary tract obstruction) could be identified. It is possible that this dog had a variation of transient hyperammonaemic syndrome, described in man and recently in a juvenile Irish wolfhound, that extended into adulthood.

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DNA Methylation Suppresses Expression of the Urea Cycle Enzyme Carbamoyl Phosphate Synthetase 1 (CPS1) in Human Hepatocellular Carcinoma

American Journal Of Pathology ◽

10.1016/j.ajpath.2010.10.023 ◽

2011 ◽

Vol 178 (2) ◽

pp. 652-661 ◽

Cited By ~ 58

Author(s):

Hongyan Liu ◽

Huijia Dong ◽

Keith Robertson ◽

Chen Liu

Keyword(s):

Hepatocellular Carcinoma ◽

Dna Methylation ◽

Urea Cycle ◽

Human Hepatocellular Carcinoma ◽

Carbamoyl Phosphate Synthetase ◽

Carbamoyl Phosphate ◽

Cycle Enzyme ◽

Carbamoyl Phosphate Synthetase 1 ◽

Urea Cycle Enzyme

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Fluoroless catheter ablation of supraventricular and ventricular arrhythmias in pregnancy: validation of a standard approach in a large multicenter registry

European Heart Journal ◽

10.1093/ehjci/ehaa946.0412 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

S Stec ◽

K Styczkiewicz ◽

J Sledz ◽

A Sledz ◽

M Chrabaszcz ◽

...

Keyword(s):

Catheter Ablation ◽

Ventricular Arrhythmia ◽

Pregnant Women ◽

Ventricular Arrhythmias ◽

Study Group ◽

Heart Team ◽

Femoral Access ◽

Electroanatomic Mapping System ◽

Multicenter Registry ◽

In Pregnancy

Abstract Background An increasing experience in zero- (ZF) or near-zero fluoroscopy catheter ablation (CA) supports the implementation of early, fluoroless approach for recurrent, symptomatic arrhythmias in pregnancy. Purpose The aim of the study was to evaluate the feasibility, efficacy, and safety of CA with a standardized ZF approach during pregnancy. Methods Data were derived from a large prospective multicenter registry (ELEKTRO-RARE-A-CAREgistry). Between 2012 and 2019, more than 2655 CA procedures were performed in women in intention-to-treat using a ZF fluoroscopy approach. The procedures were performer using: 1) femoral access, 2) double-catheter technique, without intracardiac echocardiography, 3) electroanatomic mapping system (Ensite, Abbott, USA) for mapping and navigation, 4) conscious, light sedation. Shared decision making approach was applied, including a pregnancy heart team consultations. Results The study group consisted of 18 pregnant women (mean age: 30.3±5.0 years; range: 19–38 years; mean gestational age during CA: 21.4±9.2 weeks; range: 7–36 weeks). All pregnant women had no overt structural heart disease. Among women in reproductive age, pregnant women referred for ZF-CA approach accounted for approximately 2% of procedures. In the study group, the major indications for CA included: AVNRT (n=10); OAVRT/WPW (n=2); focal idiopathic ventricular arrhythmia (n=4), AT (n=1) and AF (n=1). Five women had double substrate for CA. In AF case general anesthesia and transesophageal echocardiography were used to monitor ZF-transseptal puncture and right-sided pulmonary vein isolation. All procedures were successfully completed without fluoroscopy, and without serious maternal or fetal complications. The procedure and ablation application times were 55.0±30.0 min and 394±338 s, respectively. In one patient second procedure for idiopathic ventricular arrhythmia was postponed after delivery. Conclusion Implementation of pregnancy heart team and a standard fluoroless protocol for CA in daily electrophysiological practice allowed an early, safe, and effective CA of maternal supraventricular tachycardia and idiopathic ventricular arrhythmias in pregnancy. Funding Acknowledgement Type of funding source: None

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