Neurodevelopmental Outcome in Very Low Birth Weight Infants Exposed to Donor Milk

2021 ◽  
Author(s):  
Kousiki Patra ◽  
Michelle M. Greene ◽  
Grace Tobin ◽  
Gina Casini ◽  
Anita L. Esquerra-Zwiers ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Neurodevelopmental Outcome ◽  
Regression Analyses ◽  
Low Birth Weight Infants ◽  
Donor Milk ◽  
Preterm Formula ◽  
Before And After ◽  
The Impact

Objective This study was aimed to evaluate the impact of donor milk (DM) received in the first 28 days of life (DOL) on neurodevelopmental (ND) outcome at 20-month corrected age (CA) in very low birth weight (VLBW) infants. Study Design A total of 84 infants born in 2011 to 2012 who received only mother's own milk (MOM) and/or preterm formula (PF) was compared with 69 infants born in 2013 to 2014 who received MOM and/or DM. Daily enteral intake of MOM, DM, and PF was collected through 28 DOL. ND outcomes were assessed with the Bayley-III. Multiple regression analyses were adjusted for the effect of social and neonatal risk factors, alongside era of birth on ND outcome. Results Infants exposed to DM were born to older mothers (p < 0.01) and had higher incidence of severe brain injury (p = 0.013). Although DM group infants received first feed at earlier DOL (p < 0.001), there were no differences in MOM intake at DOL 14 or 28 between the two groups. In regression analyses, DM group did not predict 20-month ND outcome. Conclusion There were no differences in ND outcome between infants born before and after the introduction of DM. This may have been due to the similar percent of MOM at DOL 14 and 28 in the two eras. Key Points

scholarly journals Erratum: Neurodevelopmental Outcome in Very Low Birth Weight Infants Exposed to Donor Milk

2021 ◽  
Author(s):  
Kousiki Patra ◽  
Michelle M. Greene ◽  
Grace Tobin ◽  
Gina Casini ◽  
Anita L. Esquerra-Zwiers ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Neurodevelopmental Outcome ◽  
Low Birth Weight Infants ◽  
Donor Milk

scholarly journals Impact of Different Types of Nosocomial Infection on the Neurodevelopmental Outcome of Very Low Birth Weight Infants

Children ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 207
Author(s):  
Karin Pichler ◽  
Vito Giordano ◽  
Gereon Tropf ◽  
Renate Fuiko ◽  
Angelika Berger ◽  
...  
Keyword(s):  
Risk Factor ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Neurodevelopmental Outcome ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Low Birth Weight Infants ◽  
Neurodevelopmental Outcomes ◽  
The Impact

Nosocomial infections (NIs) are important conditions associated with mortality and morbidity in very low birth weight infants (VLBWIs). The aim of this study was to investigate the impact of NIs and the different subtypes on neurodevelopmental outcomes in a cohort of VLBWIs. VLBWIs born with a gestational age between 23 0/7 and 31 6/7 weeks in a level III neonatal center were enrolled. Neonatal morbidities as well as the neurodevelopmental outcome at 2 years of corrected age were analyzed. Six-hundred infants completed the study successfully. Of these, 38% experienced an NI episode. NIs were associated with an increased risk of neonatal complications, such as brain injury, bronchopulmonary dysplasia (BPD) and death, and were a significant risk factor for adverse motor development at 2 years of corrected age in our cohort of VLBWIs. The negative impact of NIs on neurodevelopmental outcomes was particularly associated with necrotizing enterocolitis (NEC), suspected NIs and Gram-positive NIs. This study demonstrated that NIs are a significant risk factor for both morbidity and mortality as well as adverse neurodevelopmental outcomes in VLBWIs.

scholarly journals Neurodevelopmental outcome of preterm very low birth weight infants admitted to an Italian tertiary center over an 11-year period

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Stefania Longo ◽  
Camilla Caporali ◽  
Camilla Pisoni ◽  
Alessandro Borghesi ◽  
Gianfranco Perotti ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Neurodevelopmental Outcome ◽  
International Studies ◽  
Perinatal Complications ◽  
Neurological Assessment ◽  
Low Birth Weight Infants ◽  
Tertiary Center

AbstractPreterm very low birth weight infants (VLBWi) are known to be at greater risk of adverse neurodevelopmental outcome. Identifying early factors associated with outcome is essential in order to refer patients for early intervention. Few studies have investigated neurodevelopmental outcome in Italian VLBWi. The aim of our longitudinal study is to describe neurodevelopmental outcome at 24 months of corrected age in an eleven-year cohort of 502 Italian preterm VLBWi and to identify associations with outcome. At 24 months, Griffiths’ Mental Developmental Scales were administered. Neurodevelopmental outcome was classified as: normal, minor sequelae (minor neurological signs, General Quotient between 76 and 87), major sequelae (cerebral palsy; General Quotient ≤ 75; severe sensory impairment). 75.3% showed a normal outcome, 13.9% minor sequelae and 10.8% major sequelae (3.8% cerebral palsy). Male gender, bronchopulmonary dysplasia, abnormal neonatal neurological assessment and severe brain ultrasound abnormalities were independently associated with poor outcome on multivariate ordered logistic regression. Rates of major sequelae are in line with international studies, as is the prevalence of developmental delay over cerebral palsy. Analysis of perinatal complications and the combination of close cUS monitoring and neurological assessment are still essential for early identification of infants with adverse outcome.

Colloid infusion in the perinatal period and abnormal neurodevelopmental outcome in very low birth weight infants

2002 ◽  
Vol 161 (6) ◽  
pp. 319-323 ◽  
Author(s):  
Anne Greenough ◽  
Paul Cheeseman ◽  
Vasiliki Kavvadia ◽  
Gabriel Dimitriou ◽  
Margaret Morton
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Neurodevelopmental Outcome ◽  
Perinatal Period ◽  
Low Birth Weight Infants ◽  
Colloid Infusion
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