One-Year Outcomes of the Paclitaxel-Eluting Stent for TASC C and D Femoropopliteal Lesions in Real World

Background: Hepatic encephalopathy (HE), a neuropsychiatric complication of decompensated cirrhosis, is associated with high mortality and high risk of recurrence. Rifaximin add-on to lactulose for 3 to 6 months is recommended for the prevention of recurrent episodes of HE after the second episode. However, whether the combination for more than 6 months is superior to lactulose alone in the maintenance of HE remission is less evident. Therefore, the aim of this study is to evaluate the one-year efficacy of rifaximin add-on to lactulose for the maintenance of HE remission in Taiwan. Methods: We conducted a real-world single-center retrospective cohort study to compare the long-term efficacy of rifaximin add-on to lactulose (group R + L) versus lactulose alone (group L, control group). Furthermore, the treatment efficacy before and after rifaximin add-on to lactulose was also analyzed. The primary endpoint of our study was time to first HE recurrence (Conn score ≥ 2). All patients were followed up every three months until death, and censored at one year if still alive. Results and Conclusions: 12 patients were enrolled in group R + L. Another 31 patients were stratified into group L. Sex, comorbidity, ammonia level, and ascites grade were matched while age, HE grade, and model for end-stage liver disease (MELD) score were adjusted in the multivariable logistic regression model. Compared with group L, significant improvement in the maintenance of HE remission and decreased episodes and days of HE-related hospitalizations were demonstrated in group R + L. The serum ammonia levels were significantly lower at the 3rd and 6th month in group 1. Concerning changes before and after rifaximin add-on in group R + L, mini-mental status examination (MMSE), episodes of hospitalization, and variceal bleeding also improved at 6 and 12 months. Days of hospitalization, serum ammonia levels also improved at 6th month. Except for concern over price, no patients discontinued rifaximin due to adverse events or complications. The above results provide evidence for the one-year use of rifaximin add-on to lactulose in reducing HE recurrence and HE-related hospitalization for patients with decompensated cirrhosis.

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Mortality in older adults following a fragility fracture: real-world retrospective matched-cohort study in Ontario

BMC Musculoskeletal Disorders ◽

10.1186/s12891-021-03960-z ◽

2021 ◽

Vol 22 (1) ◽

Cited By ~ 2

Author(s):

Jacques P. Brown ◽

Jonathan D. Adachi ◽

Emil Schemitsch ◽

Jean-Eric Tarride ◽

Vivien Brown ◽

...

Keyword(s):

Cohort Study ◽

Hip Fracture ◽

Fragility Fracture ◽

Mortality Risk ◽

Real World ◽

First Year ◽

Matched Cohort ◽

Matched Cohort Study ◽

Fracture Cohort ◽

One Year

Abstract Background Recent studies are lacking reports on mortality after non-hip fractures in adults aged > 65. Methods This retrospective, matched-cohort study used de-identified health services data from the publicly funded healthcare system in Ontario, Canada, contained in the ICES Data Repository. Patients aged 66 years and older with an index fragility fracture occurring at any osteoporotic site between 2011 and 2015 were identified from acute hospital admissions, emergency and ambulatory care using International Classification of Diseases (ICD)-10 codes and data were analyzed until 2017. Thus, follow-up ranged from 2 years to 6 years. Patients were excluded if they presented with an index fracture occurring at a non-osteoporotic fracture site, their index fracture was associated with a trauma code, or they experienced a previous fracture within 5 years prior to their index fracture. This fracture cohort was matched 1:1 to controls within a non-fracture cohort by date, sex, age, geography and comorbidities. All-cause mortality risk was assessed. Results The survival probability for up to 6 years post-fracture was significantly reduced for the fracture cohort vs matched non-fracture controls (p < 0.0001; n = 101,773 per cohort), with the sharpest decline occurring within the first-year post-fracture. Crude relative risk of mortality (95% confidence interval) within 1-year post-fracture was 2.47 (2.38–2.56) in women and 3.22 (3.06–3.40) in men. In the fracture vs non-fracture cohort, the absolute mortality risk within one year after a fragility fracture occurring at any site was 12.5% vs 5.1% in women and 19.5% vs 6.0% in men. The absolute mortality risk within one year after a fragility fracture occurring at a non-hip vs hip site was 9.4% vs 21.5% in women and 14.4% vs 32.3% in men. Conclusions In this real-world cohort aged > 65 years, a fragility fracture occurring at any site was associated with reduced survival for up to 6 years post-fracture. The greatest reduction in survival occurred within the first-year post-fracture, where mortality risk more than doubled and deaths were observed in 1 in 11 women and 1 in 7 men following a non-hip fracture and in 1 in 5 women and 1 in 3 men following a hip fracture.

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TCT-741 Real world one-year clinical outcome of biodegradable polymer sirolimus-eluting stent in single center, all-comers, consecutive 1727 cases

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2017.09.976 ◽

2017 ◽

Vol 70 (18) ◽

pp. B314

Author(s):

Yutaka Tadano ◽

Daitaro Kanno ◽

Daisuke Hachinohe ◽

Yoshifumi Kashima ◽

Morio Enomoto ◽

...

Keyword(s):

Clinical Outcome ◽

Real World ◽

Biodegradable Polymer ◽

Single Center ◽

Sirolimus Eluting Stent ◽

One Year

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Reply to: ‘Comment on: ‘One-year real-world outcomes in patients receiving fixed-dosing aflibercept for neovascular age-related macular degeneration’

Eye ◽

10.1038/eye.2017.212 ◽

2017 ◽

Vol 32 (2) ◽

pp. 479-481

Author(s):

H Almuhtaseb ◽

A Lotery

Keyword(s):

Macular Degeneration ◽

Real World ◽

Age Related Macular Degeneration ◽

Age Related ◽

One Year

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One-year effectiveness and safety of ustekinumab in Ulcerative Colitis: a multicenter real-world study from Italy

Expert Opinion on Biological Therapy ◽

10.1080/14712598.2021.1981855 ◽

2021 ◽

Author(s):

Michele Francesco Chiappetta ◽

Anna Viola ◽

Mauro Mastronardi ◽

Laura Turchini ◽

Sonia Carparelli ◽

...

Keyword(s):

Ulcerative Colitis ◽

Real World ◽

One Year

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Perceived lack of control and conspiracy theory beliefs in the wake of political strife and natural disaster

Psihologija ◽

10.2298/psi201115009s ◽

2021 ◽

pp. 9-9

Author(s):

Ana Stojanov ◽

Jesse Bering ◽

Jamin Halberstadt

Keyword(s):

Experimental Evidence ◽

Natural Disaster ◽

Real World ◽

Conspiracy Theory ◽

Name Change ◽

Lack Of Control ◽

Limited Support ◽

Conspiracy Beliefs ◽

One Year ◽

Control Hypothesis

While lack of control is one plausible explanation for conspiracy beliefs, the experimental evidence is mixed. We present two naturalistic studies that offer some limited support for the control hypothesis. In the first, Macedonians living in (North) Macedonia (N = 116) completed a conspiracy ideation scale immediately after a national referendum on the country?s name change from ?Macedonia? to ?North Macedonia,? and one year after. The opposition, whose control was lowered after the name change, increased their conspiracy beliefs, but supporters did not. Study 2, conducted with Americans (N = 266) in the wake of a series of devastating tornadoes, replicated and expanded the first study: the effects were evident only for the threatening event-related conspiracy beliefs. These studies suggest a possible link between lack of control and conspiracy beliefs in the real world.

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