High-Frequency Three-Dimensional Lumen Volume Ultrasound Is a Sensitive Method to Detect Early Aneurysmal Change in Elastase-Induced Murine Abdominal Aortic Aneurysm

Abstract Objective The aim of this study was to investigate the reproducibility of anterior–posterior diameter (APdmax) and three-dimensional lumen volume (3DLV) measurements of abdominal aortic aneurysms (AAA) in a classical murine AAA model. We also compared the magnitude of change in the aortic size detected with each method of assessment. Methods Periadventitial application of porcine pancreatic elastase (PPE AAA) or sham surgery was performed in two cohorts of mice. Cohort 1 was used to assess for observer variability with the APdmax and 3DLV measurements. Cohort 2 highlighted the relationship between APdmax and 3DLV and changes in AAA detected. Results There was no significant observer variability detected with APdmax measurement. Similarly, no significant intraobserver variability was evident with 3DLV; however, a small but significant interobserver difference was present. APdmax and 3DLV measurements of PPE AAA significantly correlated. However, changes in the AAA morphology were detected earlier with 3DLV. Conclusion APdmax and 3DLV are both reliable methods for measuring an AAA. Both these methods correlate with each other. However, changes in AAA morphology were detected earlier with 3DLV, which is important to detect subtle but important changes to aortic geometry in a laboratory setting. 3DLV measurement of AAA is a simple, reproducible, and comprehensive method for assessing changes in disease morphology.

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Automated software supported versus manual aorto-iliac diameter measurements in CT angiography of patients with abdominal aortic aneurysms: Assessment of inter- and intraobserver variation

VASA ◽

10.1024/0301-1526.34.4.255 ◽

2005 ◽

Vol 34 (4) ◽

pp. 255-261 ◽

Cited By ~ 16

Author(s):

Diehm ◽

Baumgartner ◽

Silvestro ◽

Herrmann ◽

Triller ◽

...

Keyword(s):

Ct Angiography ◽

Iliac Artery ◽

Automatic Measurement ◽

Random Order ◽

Aortic Aneurysms ◽

Intraobserver Variability ◽

Automatic Method ◽

Left Common Iliac Artery ◽

Abdominal Aortic ◽

Intraobserver Variation

Background: Open surgical or endovascular abdominal aortic aneurysm (AAA) relies on precise preprocedual imaging. Purpose of this study was to assess inter- and intraobserver variation of software-supported automated and manual multi row detector CT angiography (MDCTA) in aortoiliac diameter measurements before AAA repair. Patients and methods: Thirty original MDCTA data sets (4 times 2mm collimation) of patients scheduled for endovascular AAA repair were studied on a dedicated software capable of creating two-dimensional reformatted planes orthogonal to the aortoiliac center-line. Measurements were performed twice with a four-week interval between readings. Data were analysed by two blinded readers at random order. Two different measurement methods were performed: reader-assisted freehand wall-to-wall measurement and semi-automatic measurement. Results: Aortoiliac diameters were significantly underestimated by the semi-automatic method as compared to reader-assisted measurements (p < 0.0031). Intraobserver variability of AAA diameter calculation was not significant (p > 0.15) for reader-assisted measurements except for the diameter of the left common iliac artery in reader 2 (p = 0.0045) and it was not significant (p > 0.14) using the semi-automatic method. Interobserver variability was not significant for AAA diameter measurements using the reader-assisted method and for proximal neck analysis with the semi-automatic method (p > 0.27). Relevant interobserver variation was observed for semi-automatic measurement of maximum AAA (p = 0.0007) and iliac artery diameters (p = 0.024). Conclusions: Dedicated MDCTA software provides a useful tool to minimize aortoiliac diameter measurement variation and to improve imaging precision before AAA repair. For reliable AAA diameter analysis the reader-assisted freehand measurement method is recommended to be applied to a set of reformatted CT data as provided by the software used in this study.

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Commentary on “Follow-up on Small Abdominal Aortic Aneurysms Using Three Dimensional Ultrasound: Volume Versus Diameter”

European Journal of Vascular and Endovascular Surgery ◽

10.1016/j.ejvs.2017.08.010 ◽

2017 ◽

Vol 54 (4) ◽

pp. 446

Author(s):

Regula S. von Allmen

Keyword(s):

Three Dimensional ◽

Abdominal Aortic Aneurysms ◽

Aortic Aneurysms ◽

Volume Versus ◽

Abdominal Aortic

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Method for Incorporating Three-Dimensional Residual Stresses Into Patient-Specific Simulations of Arteries

Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions ◽

10.1115/sbc2013-14232 ◽

2013 ◽

Author(s):

David M. Pierce ◽

Thomas E. Fastl ◽

Hannah Weisbecker ◽

Gerhard A. Holzapfel ◽

Borja Rodriguez-Vila ◽

...

Keyword(s):

Medical Imaging ◽

Three Dimensional ◽

Constitutive Models ◽

Abdominal Aortic Aneurysms ◽

Aortic Aneurysms ◽

Patient Specific ◽

Abdominal Aortic ◽

Model Geometry ◽

Reconstructed Model

Through progress in medical imaging, image analysis and finite element (FE) meshing tools it is now possible to extract patient-specific geometries from medical images of, e.g., abdominal aortic aneurysms (AAAs), and thus to study clinically relevant problems via FE simulations. Medical imaging is most often performed in vivo, and hence the reconstructed model geometry in the problem of interest will represent the in vivo state, e.g., the AAA at physiological blood pressure. However, classical continuum mechanics and FE methods assume that constitutive models and the corresponding simulations start from an unloaded, stress-free reference condition.

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Abstract 240: Serum Cholesterol and Angiotensin-Induced Abdominal Aortic Aneurysm in Hypercholesterolemic Mice

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvb.33.suppl_1.a240 ◽

2013 ◽

Vol 33 (suppl_1) ◽

Author(s):

Petra A Prins ◽

Michael Hill ◽

David Airey ◽

Sam Nwosu ◽

Prudhvidhar R Perati ◽

...

Keyword(s):

Aortic Aneurysms ◽

Cholesterol Concentration ◽

Linear Mixed Effect Model ◽

Hemodynamic Parameters ◽

Mixed Effect ◽

Regression Methods ◽

Effect Model ◽

Abdominal Aortic ◽

And Control ◽

The Relationship

Background Although hyperlipidemia is known to augment the incidence of abdominal aortic aneurysms (AAA) in the AngII-induced model of apolipoprotein E -/- mice, its relationship to AAA size is unknown. Therefore, we evaluated the relationship between total cholesterol concentration (TC) and change (delta) in aortic diameter. Methods TC was measured in 36 male mice that underwent a 4-week infusion period with saline (n=9) or AngII (1500 ng/kg/min; n=27), along with serial measurements of pulse rate (PR), and pulse (PP), mean arterial (MAP), systolic (SBP) and diastolic (DBP) pressure. A linear mixed effect model was used to assess the relationship between all hemodynamic parameters and delta. Nonparametric and linear regression methods were used to evaluate TC in relation to delta. Results TC did not differ between AngII and control mice (Figure, bottom left) (p=0.18). The burden of atherosclerosis was greater among AngII-exposed mice versus control, but did not differ by presence or size of AAA (Figure, bottom right). None of the hemodynamic parameters were predictive of delta (SBP, p = 0.66; DBP, p = 0.66; MAP, p = 0.55; PP, p = 0.66; and PR, p = 0.39). Mean TC was higher among mice with large versus small AAA (552.6 vs. 393.5 mg/ ml, p<0.05; Figure, top right). The nonparametric smoothing line (Figure, top left) suggests a first order relationship between delta and TC (p for trend < 0.001). AngII (ß = 0.48, p < 0.001) and TC (ß = 0.0015, p = 0.003) were independent predictors in the linear model for delta. Conclusions Our findings suggest that TC is incrementally associated with AAA size. These findings may have potential clinical relevance for risk assessment in AAA patients. Figure

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Two-dimensional versus three-dimensional CT angiography in analysis of anatomical suitability for stentgraft repair of abdominal aortic aneurysms

Acta Radiologica ◽

10.1258/ar.2010.100229 ◽

2011 ◽

Vol 52 (3) ◽

pp. 317-323 ◽

Cited By ~ 24

Author(s):

Georgios A Pitoulias ◽

Konstantinos P Donas ◽

Stefan Schulte ◽

Eleni A Aslanidou ◽

Dimitrios K Papadimitriou

Keyword(s):

Ct Angiography ◽

Three Dimensional ◽

Abdominal Aortic Aneurysms ◽

Aortic Aneurysms ◽

Two Dimensional ◽

Abdominal Aortic

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PS18. Imaging of Abdominal Aortic Aneurysms: Computerized Tomography and Three-Dimensional Ultrasound Scan: A Comparison

Journal of Vascular Surgery ◽

10.1016/j.jvs.2011.03.074 ◽

2011 ◽

Vol 53 (6) ◽

pp. 34S-35S

Author(s):

Arjun Jayaraj ◽

Daniel Leotta ◽

Marla Paun ◽

Beach Kirk ◽

Kohler Ted ◽

...

Keyword(s):

Computerized Tomography ◽

Three Dimensional ◽

Abdominal Aortic Aneurysms ◽

Aortic Aneurysms ◽

Ultrasound Scan ◽

Abdominal Aortic

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Wall Stresses Before and After Endovascular Repair of Abdominal Aortic Aneurysms

Advances in Bioengineering ◽

10.1115/imece2004-61556 ◽

2004 ◽

Cited By ~ 5

Author(s):

Elena S. Di Martino ◽

Ajay Bohra ◽

Christine Scotti ◽

Ender Finol ◽

David A. Vorp

Keyword(s):

Endovascular Aneurysm Repair ◽

Three Dimensional ◽

Invasive Procedure ◽

Aortic Aneurysms ◽

Aortic Tissue ◽

Type I ◽

Abdominal Aortic ◽

Before And After ◽

Anchoring System ◽

Three Dimensional Finite Element

Endovascular aneurysm repair (EVAR) technique is a minimally invasive procedure approach to abdominal aortic aneurysm (AAA) repair. Following EVAR, isolated aortic tissue starts remodeling after the new blood path is established. The commercially available endovascular grafts (EVG) have been found to be prone to Type I endoleak, which is re-pressurization of the degenerated AAA sac following a breach in the seal mechanism of the EVG or migration due to failure of the mechanism holding the graft in place (Chuter, 2002) These inadequacies of EVGs might be attributed to the effect of non-optimal design of graft anchoring system. In the present study, we utilized pre-operative and post-operative computer tomography (CT) data with previously derived material properties to construct three-dimensional finite element (FE) models for AAA before and after the EVAR procedure. We studied the nature of stresses acting on the aorta before and after EVAR. In particular we investigated the physical forces acting on the EVG and how they are transferred to the aortic wall at graft anchoring sites.

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