scholarly journals Hyperammonemic Encephalopathy Associated with 5-Flurouracil Infusion in Head and Neck Cancer: Case Report and Review of the Literature

Author(s):  
Saikat Das ◽  
Aftab Ahmad ◽  
Pallav Prasun ◽  
Vipin Kharade ◽  
Manish Gupta

AbstractHyperammonemic encephalopathy is an uncommon, potentially lethal adverse effect of 5-fluorouracil (5-FU). Being one of the most common and versatile chemotherapy agents, it is important to understand this important side effect of 5FU. There is paucity of data in this subject. Here, we report a case of 5FU-induced encephalopathy in a patient on induction chemotherapy for head and neck cancer. In this case report, the clinical presentation, diagnosis, and management of 5FU-induced encephalopathy is reported.

2015 ◽  
Vol 33 (3) ◽  
pp. e13-e15 ◽  
Author(s):  
Marcelo Bonomi ◽  
Rachel W. Abbott ◽  
Alexis Patsias ◽  
Krzysztof Misiukiewicz ◽  
Elizabeth G. Demicco ◽  
...  

2021 ◽  
pp. 153857442110270
Author(s):  
Mario Sánchez-Canteli ◽  
Juan P. Rodrigo ◽  
Eduardo Murias Quintana ◽  
Pedro Vega ◽  
José Luis Llorente ◽  
...  

Carotid blowout syndrome (CBS) is defined as a rupture of common carotid artery or its branches. Endovascular intervention has been advocated as first line of treatment for CBS. This Case Report describes 5 patients with prior history of head and neck cancer who presented with CBS. Two patients presented as acute, 2 as impending, and one as threatened CBS. The lesions found were pseudoaneurysm and focal vascular irregularities involving the common carotid artery, cervical internal carotid artery and lingual artery. Embolization and occlusion with detachable coils of the artery was used in all patients. Technical success and immediate hemostasis were achieved in all patients. One patient presented transient cranial nerve palsy. No recurrent CBS was reported during the follow-up. In our experience, coil embolization, if possible, is a safe and efficient technique in treatment of CBS secondary to head and neck cancers.


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