scholarly journals An Interesting Case of Bilateral Hilar Lymphadenopathy Presented with Visual Impairment

2021 ◽  
Author(s):  
Chandramouli MT ◽  
Nandakishore Baikunje ◽  
Sunil Kumar Y. ◽  
Subrahmanya Bhat K. ◽  
Darshan Bajaj ◽  
...  
Keyword(s):  
Fungal Infection ◽  
Gold Standard ◽  
Cystoid Macular Edema ◽  
Interesting Case ◽  
Organ System ◽  
Unknown Etiology ◽  
Granulomatous Disease ◽  
Ocular Sarcoidosis ◽  
Bilateral Hilar Lymphadenopathy ◽  
Histopathological Evidence

AbstractSarcoidosis is a systemic granulomatous disease of unknown etiology. It primarily affects the lungs and lymphatics; however, the presentation is not always pulmonary. Uveitis is the presenting symptom in 5% of patients, predominantly in females. Cystoid macular edema is the most important sight-threatening sequela of ocular sarcoidosis. Histopathological evidence of noncaseating epithelioid granulomas from a biopsy is the gold standard for the diagnosis of ocular sarcoidosis. Diagnosis of sarcoidosis is made by exclusion of other causes of granulomatous disease, mainly tuberculosis and fungal infection and documentation of involvement of at least one additional organ system. The authors present a case of a patient with sarcoidosis involving lungs and eyes, who had uveitis as an initial presentation.

scholarly journals Sarcoidosis and Its Splenic Wonder: A Rare Case of Isolated Splenic Sarcoidosis

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Khushali Jhaveri ◽  
Abhay Vakil ◽  
Salim R. Surani
Keyword(s):  
Rare Case ◽  
Hematologic Malignancies ◽  
Pulmonary Involvement ◽  
Interesting Case ◽  
Organ System ◽  
Unknown Etiology ◽  
Granulomatous Disease ◽  
Uncommon Presentation ◽  
The Many ◽  
Noncaseating Granulomas

Sarcoidosis is a systemic granulomatous disease of unknown etiology characterized by presence of noncaseating granulomas in the involved organs. The pulmonary interstitium is most commonly affected but extrapulmonary involvement can occur in almost any other organ system. Such an involvement can occur with or without the presence of pulmonary involvement, but isolated extrapulmonary involvement has been noted only in around 10% of cases. Isolated splenomegaly is very rare and an uncommon presentation of sarcoidosis. It is clinically challenging because of the extensive differential diagnosis. Among the many considerations are hematologic malignancies, primary splenic or metastatic tumors, infiltrative disorders, inflammatory disorders, and infections. We hereby discuss an interesting case of a 40-year-old female with isolated splenic sarcoidosis.

scholarly journals Development of Hodgkin lymphoma in a patient with sarcoidosis

Reumatismo ◽  
2017 ◽  
Vol 69 (2) ◽  
pp. 84
Author(s):  
F. Gediz ◽  
A.F. Yilmaz ◽  
B. Payzin ◽  
T. Yuksel ◽  
A.O. Calli ◽  
...  
Keyword(s):  
Chronic Granulomatous Disease ◽  
Hodgkin Lymphoma ◽  
Female Patient ◽  
Unknown Etiology ◽  
Systemic Diseases ◽  
Granulomatous Disease ◽  
Hilar Lymphadenopathy ◽  
Bilateral Hilar Lymphadenopathy ◽  
Eye Lesions

Sarcoidosis is a chronic granulomatous disease of unknown etiology characterized by non-caseified granulomas in many different organs and systems. The disease most frequently manifests with bilateral hilar lymphadenopathy and infiltrations in the lungs and skin, as well as with eye lesions. It may mimic a number of systemic diseases and/or accompany them. The development of lymphoma in patients with sarcoidosis or the co-occurrence of both diseases is rarely reported in the literature. In this paper we report a female patient followed up with sarcoidosis for three years who developed Hodgkin lymphoma, according to the results of the investigations and biopsy results.

scholarly journals Microangiopathy in Ocular Sarcoidosis Using Fluorescein Gonio and Fundus Angiography from Diagnostic and Therapeutic Aspects

Diagnostics ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 39
Author(s):  
Teruhiko Hamanaka ◽  
Noriko Akabane ◽  
Tetsuro Sakurai ◽  
Soichiro Ikushima ◽  
Toshio Kumasaka ◽  
...  
Keyword(s):  
Blood Vessel ◽  
Pathological Examination ◽  
Fundus Fluorescein Angiography ◽  
Retinal Blood Vessel ◽  
Vessel Occlusion ◽  
Vascular Abnormalities ◽  
Ocular Sarcoidosis ◽  
Group I ◽  
Bilateral Hilar Lymphadenopathy ◽  
Iop Elevation

In this retrospective study, we investigated vascular abnormalities in sarcoidosis using fluorescein gonioangiography (FGA) to detect angle neovascularization (ANV), fundus fluorescein angiography (FFA), and pathological specimens from the aspects of microangiopathy. In 57 sarcoidosis patients, clinical data was reviewed by dividing the cases into three groups (Group I: histologically diagnosed; Group II: positive bilateral hilar lymphadenopathy (BHL); Group III: negative BHL). The FFA, FGA, and pathological examination data in the autopsy eyes and trabeculectomy specimens were investigated. FGA and FFA detected ANV (91%) and nodule-associated abnormalities (87%), respectively. No intraocular pressure (IOP) elevation was observed after continuous topical betamethasone, except in the steroid responder group. Maximum IOP had significant correlation with nodules in the angle (p = 0.02696) and visual field defect (p = 0.0151). Granulomas adjacent to blood vessels, including the Schlemm’s canal, and thickening of the retinal blood vessel wall caused occlusion of those vessels. Photocoagulation was required for retinal tears (14%) and the retinal blood vessel occlusion (7%). Suppression of IOP elevation via continuous topical betamethasone may be important to avoid irreversible outflow-route changes and optic-nerve damage, and the concept of microangiopathy in ocular sarcoidosis may be important for understanding the proper treatment of serious complications.

scholarly journals Erratum: Pulmonary fungal infection diagnosis in chronic granulomatous disease patients

2007 ◽  
Vol 42 (10) ◽  
pp. 987-987
Author(s):  
Sergio Sierre ◽  
Jose Lipsich ◽  
Patricia Santos ◽  
Claudia Hernandez ◽  
Monica Siminovich ◽  
...  
Keyword(s):  
Fungal Infection ◽  
Chronic Granulomatous Disease ◽  
Granulomatous Disease ◽  
Infection Diagnosis

Sarcoidosis Presenting as Nasal Obstruction

1993 ◽  
Vol 7 (3) ◽  
pp. 133-138 ◽  
Author(s):  
Mark J. Shikowitz ◽  
Aijaz Alvi
Keyword(s):  
Respiratory Tract ◽  
Nasal Obstruction ◽  
Clinical Presentation ◽  
Multiple Organ ◽  
Diagnostic Workup ◽  
Unknown Etiology ◽  
Granulomatous Disease ◽  
Upper Respiratory Tract ◽  
Important Symptom ◽  
Upper Respiratory

Sarcoidosis is a chronic systemic granulomatous disease of unknown etiology. The histology of this disease was first reported by Boeck in 1899. Since that time many reports of multiple organ involvement have been published. Symptoms relating to the upper respiratory tract are not uncommon. Nasal obstruction as the presenting and primary complaint in sarcoidosis however is a rare but important symptom as it may lead to the diagnosis of this treatable disease. We present three patients whose initial complaint of progressive nasal obstruction heralded the diagnosis of sarcoidosis upon further workup. The clinical presentation, diagnostic workup, histology, and management of nasal sarcoidosis are discussed.

scholarly journals A Case of Sarcoidosis Disseminated to Skeletal Tissues

2013 ◽  
Vol 1 (1) ◽  
pp. 43-45
Author(s):  
Edon Rabinowitz ◽  
Chinwe Ogedegbe ◽  
Joseph Feldman
Keyword(s):  
Cell Tumor ◽  
Unknown Etiology ◽  
Granulomatous Disease ◽  
Presenting Symptoms ◽  
Organ Systems ◽  
Mediastinal Germ Cell Tumor ◽  
History Of ◽  
Hilar Adenopathy ◽  
Eye Lesions ◽  
Musculoskeletal Involvement

Sarcoidosis is a systemic granulomatous disease of unknown etiology that typically affects young adults. Diagnostic criteria for sarcoidosis include involvement of two or more of the following organ systems: 1) pulmonary infiltrates; 2) bilateral hilar adenopathy; and 3) skin and/or eye lesions. Musculoskeletal system is less commonly involved. For that reason potential presenting symptoms can vary and make the diagnosis very challenging; particularly if a patient has symptoms that mimic other conditions. Musculoskeletal involvement for example can mimic malignancy. The following case describes a patient with known history of primary metastatic mediastinal Germ Cell Tumor (GCT) with teratomatous elements who is diagnosed with sarcoidosis involving skeletal tissues.

Clinical Characteristics and Organ System Involvement in Sarcoidosis: Comparison of the University of Minnesota Cohort and Other Cohorts

2020 ◽  
Author(s):  
Hok Sreng ◽  
David M Perlman ◽  
Chetan Shenoy ◽  
Daniel J Steinberger ◽  
Rebecca J Cogswell ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
High Variability ◽  
Organ System ◽  
Assessment Instrument ◽  
Genomic Research ◽  
Unknown Etiology ◽  
University Of Minnesota ◽  
System Involvement ◽  
Tertiary Center ◽  
The University

Abstract Background: Sarcoidosis is a systemic granulomatous disease of unknown etiology. Clinical cohort studies of different populations are important to understand the high variability in clinical presentation and disease course of sarcoidosis. The aim of the study is to evaluate clinical characteristics, including organ involvement, pulmonary function tests, and laboratory parameters, in a sarcoidosis cohort at the University of Minnesota. We compare the organ system involvement of this cohort with other available cohorts. Methods: We conducted a retrospective data collection and analysis of 187 subjects with biopsy-proven sarcoidosis seen at a tertiary center. Organ system involvement was determined using the WASOG sarcoidosis organ assessment instrument. Clinical phenotype groups were classified using the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis criteria. Results: Mean subject age at diagnosis was 45.8 ± 12.4, with a higher proportion of males (55.1%), and a higher proportion of blacks (17.1%) compared to the racial distribution of Minnesota residents (5.95%). The majority (71.1%) of subjects required anti-inflammatory therapy for at least 1 month. Compared to the A Case Control Etiologic Study of Sarcoidosis cohort, there was a higher frequency of extra-thoracic lymph node (34.2% vs. 15.2%), eye (20.9% vs. 11.8%), liver (17.6% vs. 11.5%), spleen (20.9% vs. 6.7%), musculoskeletal (9.6% vs. 0.5%), and cardiac (10.7% vs. 2.3%) involvement in our cohort. A multisystem disease with at least five different organs involved was identified in 13.4% of subjects. A restrictive physiological pattern was observed in 21.6% of subjects, followed by an obstructive pattern in 17.3% and mixed obstructive and restrictive pattern in 2.2%. Almost half (49.2%) were Scadding stages II/III. Commonly employed disease activity markers, including soluble interleukin-2 receptor and angiotensin-converting enzyme, did not differ between treated and untreated groups. Conclusions: This cohort features a relatively high frequency of high-risk sarcoidosis phenotypes including cardiac and multiorgan disease. Commonly-utilized serum biomarkers do not identify subpopulations that require or do better with treatment. Findings from this study present further the high-variability nature of sarcoidosis and the need for a more reliable biomarker to predict and measure disease severity and outcomes for better clinical management for sarcoidosis patients.

scholarly journals The Clinical Manifestations of Femoral-Facial Syndrome in an Orthopaedic Patient

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Abdullah Ghali ◽  
Luis Salazar ◽  
David Momtaz ◽  
Gautham Prabhakar ◽  
Preston Richier ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Disease Process ◽  
Maternal Diabetes ◽  
Interesting Case ◽  
Unknown Etiology ◽  
Rare Congenital Disorder ◽  
Surgical History ◽  
Pediatric Orthopaedic ◽  
Management Recommendations ◽  
Femoral Hypoplasia

Femoral-facial syndrome (FFS) is an exceedingly rare congenital disorder of unknown etiology related to maternal diabetes during pregnancy. It is characterized by variations of bilateral femoral hypoplasia and facial anomalies. We discuss an interesting case of a 3-year-old girl with FFS with an extensive surgical history who presented to a pediatric orthopaedic clinic with ankle pains and absent femurs. As this disease process is not frequently encountered, it is imperative for the practicing clinician to be aware of the various presentations. In this study, we discuss the different orthopaedic presentations in the literature and discuss various management recommendations.

scholarly journals An interesting case of mediastinitis

2015 ◽  
Vol 4 (3S) ◽  
pp. 43-46
Author(s):  
Cristina Pellissetto
Keyword(s):  
Chest Pain ◽  
Gold Standard ◽  
Inflammatory Process ◽  
Interesting Case ◽  
X Ray ◽  
Inflammatory Index ◽  
Contiguous Spread ◽  
Acute Mediastinitis

Mediastinitis is an inflammatory process; it can be either acute or chronic and it can advance rapidly. Causes of acute mediastinitis usually arise from perforation of the oesophagus or from contiguous spread of neck infections. An important neck or chest pain with fever or the onset of inflammatory index and the enlargement of the mediastinal x-ray image should lead to suspect mediastinitis. The TC-scan of neck and thorax is the gold standard for mediastinitis diagnosis.

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