Blood Parameter Analysis in Pediatric MOG-Antibody-Associated Disorders

2021 ◽  
Author(s):  
A. Peternell ◽  
M. Breu ◽  
M. Preisel ◽  
M. Schimmel ◽  
A. Eisenkölbl ◽  
...  
Keyword(s):  
Parameter Analysis ◽  
Blood Parameter

scholarly journals Blood parameter analysis and morphological alterations as biomarkers on the health of Hoplias malabaricus and Geophagus brasiliensis

2006 ◽  
Vol 49 (3) ◽  
pp. 441-448 ◽  
Author(s):  
Silvia Romão ◽  
Lucélia Donatti ◽  
Matheus O. Freitas ◽  
Josiane Teixeira ◽  
Josiana Kusma
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Hemoglobin Concentration ◽  
Parameter Analysis ◽  
Mean Corpuscular Hemoglobin ◽  
Blood Parameter ◽  
Blood Cell Count ◽  
Hoplias Malabaricus ◽  
Morphological Alterations ◽  
Geophagus Brasiliensis

This study aimed to assess the influence of the environment on fish health. Samples of Hoplias malabaricus and Geophagus brasiliensis, were collected from three different environments: area I was urban and areas II and III were rural. Analyses of red blood cell count, microhematocrit, hemoglobin concentration, white blood cell count and differential white cell count in blood smear were carried out. Mean corpuscular volume and mean corpuscular hemoglobin concentration were calculated. To analyze morphological alterations, gills, liver, kidney and gonads were submitted to routine histological processing. Individuals collected from area III had slightly lower blood indices than collected from area I . Severe kidney changes, degeneration of and crystallization within kidney tubules were observed. In area I, crystallization was observed in 92% of the specimens of G. brasiliensis. These results suggested that such alterations were related with poor water circulation in the place.

scholarly journals Assessment of chemotherapy-induced organ damage with 68Ga-labeled duramycin

2019 ◽  
Author(s):  
Anne Rix ◽  
Natascha Ingrid Drude ◽  
Anna Mrugalla ◽  
Ferhan Baskaya ◽  
Koon Yan Pak ◽  
...  
Keyword(s):  
Specific Binding ◽  
Parameter Analysis ◽  
Blood Parameter ◽  
Serum Samples ◽  
Promising Alternative ◽  
High Background ◽  
Organ Toxicity ◽  
Pet Tracer ◽  
Pet Ct

AbstractCompared to standard toxicological techniques in preclinical toxicity studies, non-invasive imaging of organ toxicity enables fast and longitudinal investigation of the whole animal. Therefore, we set out to evaluate [68Ga]Ga-NODAGA-duramycin as a positron emission tomography (PET)-tracer of cell death for detecting chemotherapy-induced organ toxicity.MethodsNODAGA-duramycin was radiolabeled with 68Ga, and quality control was done by thin layer chromatography and high performance liquid chromatography. Tracer specificity was determined in vitro by performing competitive binding experiments on ethanol treated cells. To optimize the timing of the PET/CT-based tracer evaluation, kinetic studies were performed in untreated and cisplatin-treated (20 mg/kg BW, intraperitoneal (i.p.)) BALB/cAnNRj mice. Organ uptake was analyzed in doxorubicin (4 mg/kg BW, i.p.)-, busulfan (18.8 mg/kg KG, i.p.)-, and cisplatin-treated (20 mg/kg BW, i.p.) mice, and in untreated control mice 2 hours after intravenous injection of 5–10 MBq [68Ga]Ga-NODAGA-duramycin. For immunofluorescence validation, tissue sections were stained with anti-active caspase-3 antibody. Blood and serum samples were collected to determine platelet count, aspartate transaminase, alanine transaminase, urea, creatinine, and creatine kinase values.ResultsIn vitro experiments confirmed specific binding of [68Ga]Ga-NODAGA-duramycin to dying cells. The biodistribution analysis revealed a blood half-life of 10–17 minutes and a predominantly urinary excretion of the radiotracer. Doxorubicin-, busulfan-, and cisplatin-induced organ toxicities were detected successfully using [68Ga]Ga-NODAGA-duramycin PET/CT and confirmed by immunohistochemistry as well as blood parameter analysis. Busulfan-related spleno-, cardio-, and pneumotoxicity as well as cisplatin-induced cardio- and pneumotoxicity were detected even earlier by [68Ga]Ga-NODAGA-duramycin PET/CT than by blood parameters and histological stainings. In livers and kidneys, differences between treated and untreated animals tended to occur in PET/CT at later time points than in histology due to the relatively high background in these organs. However, trends over time were comparable.Conclusion[68Ga]Ga-NODAGA-duramycin PET/CT was successfully applied to non-invasively detect chemotherapy-induced organ toxicity with high sensitivity in preclinical studies. It even depicted some toxic effects prior to immunohistochemistry and blood parameter analysis and represents a promising alternative or complementary method to standard toxicological analyses. Furthermore, the tracer has a high translational potential and may provide a valuable link between preclinical and clinical research.

Blood parameter analysis after short term exposure to weightlessness in parabolic flight

2019 ◽  
Vol 70 (4) ◽  
pp. 477-486 ◽  
Author(s):  
Nana-Yaw Bimpong-Buta ◽  
Peter Jirak ◽  
Bernhard Wernly ◽  
Michael Lichtenauer ◽  
Thorben Knost ◽  
...  
Keyword(s):  
Parabolic Flight ◽  
Parameter Analysis ◽  
Blood Parameter ◽  
Short Term ◽  
Short Term Exposure

Method application of optimal multi-parameter analysis to assess the distribution of water masses as an example of CTD data of the Barents Sea in summer 2017

2019 ◽  
pp. 38-51
Author(s):  
Valeriy G. Yakubenko ◽  
Anna L. Chultsova
Keyword(s):  
Barents Sea ◽  
Field Measurements ◽  
Structural Similarity ◽  
Water Masses ◽  
Parameter Analysis ◽  
Water Dynamics ◽  
Phosphorus Concentration ◽  
Nitrogen And Phosphorus ◽  
The Barents Sea ◽  
Expert Assessments

Identification of water masses in areas with complex water dynamics is a complex task, which is usually solved by the method of expert assessments. In this paper, it is proposed to use a formal procedure based on the application of the method of optimal multiparametric analysis (OMP analysis). The data of field measurements obtained in the 68th cruise of the R/V “Academician Mstislav Keldysh” in the summer of 2017 in the Barents Sea on the distribution of temperature, salinity, oxygen, silicates, nitrogen, and phosphorus concentration are used as a data for research. A comparison of the results with data on the distribution of water masses in literature based on expert assessments (Oziel et al., 2017), allows us to conclude about their close structural similarity. Some differences are related to spatial and temporal shifts of measurements. This indicates the feasibility of using the OMP analysis technique in oceanological studies to obtain quantitative data on the spatial distribution of different water masses.

A Basic Study of Parameter Analysis and Adaptation of Cuckoo Search

2015 ◽  
Vol 135 (6) ◽  
pp. 721-722 ◽  
Author(s):  
Wataru Kumagai ◽  
Kenichi Tamura ◽  
Junichi Tsuchiya ◽  
Keiichiro Yasuda
Keyword(s):  
Cuckoo Search ◽  
Parameter Analysis ◽  
Basic Study

ANALYSIS OF FLOOD PRONE AREAS IN NAGAN RAYA REGENCY ACEH PROVINCE

2020 ◽  
Vol 5 (1) ◽  
pp. 414
Author(s):  
Amsar Yunan
Keyword(s):  
Land Use ◽  
Spatial Data ◽  
Flood Hazard ◽  
Parameter Analysis ◽  
Thematic Maps ◽  
Aceh Province ◽  
Object Area ◽  
Use Factors ◽  
Hazard Levels ◽  
Flood Prone Areas

Maps or remote sensing can be interpreted as the process of reading using various sensors where data collected remotely can be analyzed to obtain information about the object, area or phenomenon. In this study, the author develops a flood disaster mapping information system applying overlays with scoring between the parameters. The determinant factors to provide flood hazard levels includes rainfall factors in the dasarian unit, land-use factors and land-use arbitrary factors. Of all these parameters, a scoring process will be carried out by assigning weights and values according to their respective classifications, then an overlay process will be performed using ArcGIS software. The author conducted this study in Nagan Raya Regency since this area experiences flooding annually.  Framing a thematic map of flood-prone areas in Nagan Raya Regency was designed using the flood hazard method. Spatial data that has been presented in the form of thematic maps as parameters are land use maps, landform maps, and dasarian rainfall maps (per 10 daily). The design of thematic maps that are prone to flooding is done by overlapping (overlay process). In contrast, the determination of the classification is done by adding scores to each parameter, with low, medium and high hazard levels. Parameter analysis shows the level of flood vulnerability in Nagan Raya Regency of each district, namely Beutong: high 0.21%, medium 13.68%, low 86.12%. Seunagan District: high 51.17%, medium 48.83%, low 0%. Seunagan Timur District: high 10.07%, medium 46.18%, low 43.75%. Kuala Subdistrict: high 29.66%, medium 68.99%, low 1.35%. Darul Makmur District: high 8.57%, medium 63.37%, low 28.06%. From the overall results of the study, it can be concluded that the danger of flooding in Nagan Raya Regency with a level of vulnerability: high 9.92%, moderate 42.65% and low 47.43%.

Coupled vibration model of cables and its parameter analysis

2015 ◽  
Vol 32 (3) ◽  
pp. 231
Author(s):  
Haitao Liu ◽  
Minghai Wei ◽  
Kun Lin ◽  
Yiqing Xiao
Keyword(s):  
Parameter Analysis ◽  
Coupled Vibration ◽  
Vibration Model
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