Parental Height and Weight Influence Offspring Adiposity at 2 Years; Findings from the ROLO Kids Birth Cohort Study

2021 ◽  
Author(s):  
Jean M. Donnelly ◽  
Jennifer M. Walsh ◽  
Mary K. Horan ◽  
John Mehegan ◽  
Eleanor J. Molloy ◽  
...  
Keyword(s):  
Early Childhood ◽  
Birth Cohort ◽  
Perinatal Period ◽  
Birth Cohort Study ◽  
Central Adiposity ◽  
C Peptide ◽  
Negatively Associated ◽  
Female Children ◽  
Offspring Adiposity ◽  
General Adiposity

Objective The perinatal period and in utero environment are important for fetal growth, development, and fetal programming. This study aimed to determine the effect of parental anthropometry and the maternal metabolic milieu on offspring adiposity at 2 years of age. Study Design This longitudinal birth cohort includes analysis of maternal (n = 337) and paternal (n = 219) anthropometry and maternal and fetal metabolic markers (n = 337), including glucose, homeostatic model of assessment (HOMA), C-peptide, and leptin from participants of the ROLO (the Randomized Control Trial of Low) pregnancy study, and their partners, to determine an association with offspring anthropometry at two years of age. Results Linear regression, when adjusted for confounders, indicated maternal and paternal anthropometry and was associated with offspring weight and length at 2 years of age. Maternal height was negatively associated with general adiposity in the total cohort of children (p = 0.002) and in female children (p = 0.006) and central adiposity in the total child cohort (p < 0.001). Paternal height was also negatively associated with general adiposity in all children (p = 0.002) and central adiposity in total (p = 0.023) and female children (p = 0.008). Maternal glucose, insulin resistance, and fetal C-peptide positively correlated with anthropometry in total, male, and female children. Conclusion Parental anthropometry in the perinatal period has a long-lasting effect on offspring anthropometry beyond the neonatal period. Maternal and fetal metabolic factors influence adiposity, and this extends beyond the perinatal period. Parental adiposity may play a significant role in early childhood adiposity and may be a target for interventions to decrease the risk of early childhood obesity. Key Points

The link between sleep problems in infancy and early childhood and attention problems at 5 and 14years: Evidence from a birth cohort study

2010 ◽  
Vol 86 (7) ◽  
pp. 419-424 ◽  
Author(s):  
Frances V. O'Callaghan ◽  
Abdullah Al Mamun ◽  
Michael O'Callaghan ◽  
Alexandra Clavarino ◽  
Gail M. Williams ◽  
...  
Keyword(s):  
Early Childhood ◽  
Cohort Study ◽  
Birth Cohort ◽  
Sleep Problems ◽  
Attention Problems ◽  
Birth Cohort Study ◽  
Infancy And Early Childhood

Staphylococcus aureus sensitization and allergic disease in early childhood: Population-based birth cohort study

2007 ◽  
Vol 119 (4) ◽  
pp. 930-936 ◽  
Author(s):  
Aida Semic-Jusufagic ◽  
Claus Bachert ◽  
Philippe Gevaert ◽  
Gabriele Holtappels ◽  
Lesley Lowe ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Early Childhood ◽  
Cohort Study ◽  
Birth Cohort ◽  
Allergic Disease ◽  
Population Based ◽  
Birth Cohort Study ◽  
Childhood Population

scholarly journals Early life and socio-economic determinants of dietary trajectories in infancy and early childhood – results from the HSHK birth cohort study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Narendar Manohar ◽  
Andrew Hayen ◽  
Loc Do ◽  
Jane Scott ◽  
Sameer Bhole ◽  
...  
Keyword(s):  
Early Childhood ◽  
Cohort Study ◽  
Birth Cohort ◽  
Early Life ◽  
Maternal Education ◽  
Multinomial Logistic Regression ◽  
Preschool Age ◽  
Breastfeeding Duration ◽  
Birth Cohort Study ◽  
Infancy And Early Childhood

Abstract Background Early childhood is a period when dietary behaviours are established. This study aimed to examine the longitudinal intake of core and discretionary foods and identify early life and socio-economic factors influencing those intakes. Methods Mother-infant dyads (n = 934) from the Healthy Smiles Healthy Kids study, an ongoing birth cohort study, were interviewed. The information on ‘weekly frequency of core and discretionary foods intake’ using a food frequency questionnaire was collected at 4 months, 8 months, 1 year, 2 years and 3 years age points. Group-based trajectory modelling analyses were performed to identify diet trajectories for ‘core’ and ‘discretionary’ foods respectively. A multinomial logistic regression was performed to identify the maternal and child-related predictors of resulting trajectories. Results The intake of core and discretionary foods each showed distinct quadratic (n = 3) trajectories with age. Overall, core foods intake increased rapidly in the first year of life, followed by a decline after age two, whereas discretionary foods intake increased steadily across the five age points. Multiparity (Relative Risk (RR): 0.46, 95%CI: 0.27–0.77), non-English speaking ethnicity of mother (RR: 0.66, 95%CI: 0.47–0.91) and having a single mother (RR: 0.40, 95%CI: 0.18–0.85) were associated with low trajectories of core foods intake whereas older maternal age (RR: 1.05, 95%CI: 1.01–1.08) and longer breastfeeding duration (RR: 1.02, 95%CI: 1.00–1.03) were associated with higher trajectories of core foods intake. Also, multiparity (RR 2.63, 95%CI: 1.47–4.70), low maternal education (RR 3.01, 95%CI: 1.61–5.65), and socio-economic disadvantage (RR 2.69, 95%CI: 1.31–5.55) were associated with high trajectories of discretionary foods intake. Conversely, longer duration of breastfeeding (RR 0.99, 95%CI: 0.97–0.99), and timely introduction of complementary foods (RR 0.30, 95%CI: 0.15–0.61) had a protective effect against high discretionary foods consumption in infancy and early childhood. Conclusion Children’s frequency of discretionary foods intake increases markedly as they transition from infancy to preschool age, and the trajectories of intake established during early childhood are strongly influenced by socio-demographic factors and infant feeding choices. Hence, there is a need for targeted strategies to improve nutrition in early childhood and ultimately prevent the incidence of chronic diseases in children.

Identifying predictors of early childhood caries among Australian children using sequential modelling: Findings from the VicGen birth cohort study

2020 ◽  
Vol 93 ◽  
pp. 103276 ◽  
Author(s):  
Mark Gussy ◽  
George Mnatzaganian ◽  
Stuart Dashper ◽  
Lauren Carpenter ◽  
Hanny Calache ◽  
...  
Keyword(s):  
Early Childhood ◽  
Cohort Study ◽  
Birth Cohort ◽  
Early Childhood Caries ◽  
Birth Cohort Study ◽  
Childhood Caries

scholarly journals 4264 Early Childhood and Prepubertal Overweight and Obesity are Associated with Earlier Pubertal Onset in Boys and Girls: A Prospective Birth Cohort Study

2020 ◽  
Vol 4 (s1) ◽  
pp. 28-28
Author(s):  
Li-Kuang Chen ◽  
Guoying Wang ◽  
Wendy Bennett ◽  
Xiaobin Wang
Keyword(s):  
Early Childhood ◽  
Birth Cohort ◽  
Low Income ◽  
Overweight And Obesity ◽  
Height Velocity ◽  
Birth Cohort Study ◽  
Early Puberty ◽  
Puberty Onset ◽  
Weight Trajectories ◽  
Prospective Birth Cohort

OBJECTIVES/GOALS: It is hypothesized that the global secular trend toward earlier puberty onset, with implications for many future health outcomes, is related to the obesity epidemic. This study aims to examine prospective associations between weight during specific developmental windows and timing of puberty onset. METHODS/STUDY POPULATION: This study includes 1,296 mother-infant dyads from the Boston Birth Cohort, a predominantly minority (>80% black/Hispanic), low-income, and urban prospective birth cohort recruited and followed between 1998 and 2019. Age at peak height velocity (APHV), a well-defined and standardized proxy for puberty onset, is derived by fitting height measurements recorded during clinical visits using a mixed effects growth curve model. Multiple linear regression is performed to examine the relationships between early childhood (ages 2-5y) and prepubertal (ages 6-9y) overweight and obesity, weight trajectories between these two periods, and APHV, while controlling for known contributors to early puberty. RESULTS/ANTICIPATED RESULTS: Compared to counterparts with normal BMIs, kids who were obese during ages 2-5y (boys: −0.21y, CI[−0.39, −0.04]; girls: −0.22y, CI[−0.39, −0.05]) or ages 6-9y (boys: −0.27y, CI[−0.43, −0.11]; girls: −0.37y, CI[−0.52, −0.23]) had an earlier APHV. Being overweight during ages 6-9y was also associated an earlier APHV (boys: −0.26y, CI[−0.46, −0.07]; girls: −0.26y, CI[−0.42, −0.10]). Looking at weight trajectories, kids who were persistently overweight or obese from ages 2-5y to ages 6-9y had an earlier APHV (boys: −0.28y, CI[−0.45, −0.12]; girls: −0.31y, CI[−0.46, −0.16]), as did girls with normal BMIs during ages 2-5y and who were overweight or obese during ages 6-9y (−0.45y CI[−0.64, −0.26]). DISCUSSION/SIGNIFICANCE OF IMPACT: The temporal and dose-response relationships seen in this historically understudied population suggests that childhood obesity is etiologically important in the development, and even programming, of early puberty. This has implications for prediction, prevention, and mitigation of health disparities.

scholarly journals Cord and Early Childhood Plasma Adiponectin Levels and Autism Risk: A Prospective Birth Cohort Study

2018 ◽  
Vol 49 (1) ◽  
pp. 173-184 ◽  
Author(s):  
Ramkripa Raghavan ◽  
M. Daniele Fallin ◽  
Xiumei Hong ◽  
Guoying Wang ◽  
Yuelong Ji ◽  
...  
Keyword(s):  
Early Childhood ◽  
Cohort Study ◽  
Birth Cohort ◽  
Birth Cohort Study ◽  
Plasma Adiponectin ◽  
Prospective Birth Cohort ◽  
Prospective Birth Cohort Study
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