scholarly journals Optimization of the Lung Biopsy Procedure: A Primer

2021 ◽  
Author(s):  
Dayananda Lingegowda ◽  
Bharat Gupta ◽  
Anisha Gehani ◽  
Saugata Sen ◽  
Priya Ghosh
Keyword(s):  
Patient Safety ◽  
Practice Guidelines ◽  
Diagnostic Tool ◽  
Complication Rate ◽  
Lung Biopsy ◽  
Diagnostic Yield ◽  
High Diagnostic Yield ◽  
Image Guided ◽  
Management Of Complications ◽  
Lung Biopsies

AbstractImage-guided lung biopsy plays a very important role in the diagnosis and management of lung lesions. As a diagnostic tool, it demands a high diagnostic yield and a low complication rate. It is imperative to balance the diagnostic yield and patient safety during lung biopsies. The aim of this article is to review the standard practice guidelines of lung biopsy, to describe the techniques used to minimize the complications associated with lung biopsy, and to describe the management of complications.

scholarly journals Clinical Experience with Frameless Neuronavigation Guided Biopsy for Intracranial Space Occupying Lesion

2019 ◽  
Vol 16 (1) ◽  
pp. 25-28
Author(s):  
Suraj Thulung ◽  
Suresh Bishokarma ◽  
Subash Lohani ◽  
Dinuj Shrestha ◽  
Binit Aryal ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Neurological Deficit ◽  
Complication Rate ◽  
Diagnostic Yield ◽  
P Value ◽  
Tumor Diameter ◽  
High Diagnostic Yield ◽  
Guided Biopsy ◽  
Supratentorial Tumors ◽  
Space Occupying Lesion

Biopsy is mandatory for histological diagnosis of non-resectable brain tumors. Of various techniques, neuronavigation guided biopsy provides intraoperative real-time reference and allows biopsy from multiple trajectories. The aim of this study is to assess the efficacy and accuracy of frameless neuronavigation biopsy. We retrospectively reviewed the medical archives of patients with intracranial space occupying lesion who underwent frameless neuronavigation biopsy at our institute between 2016 to 2018. All operations were performed under general anesthesia. Data were analyzed by SPSS version 20. P value of <0.05 was considered significant. There were 46 patients who underwent neuronavigation guided biopsy over the period of two years. Median age of patients was 46.5 years. Supratentorial tumors accounted for 95.8% of cases. Mean tumor diameter was 3.35 cm. Accuracy was 89.1%. More than half were glial tumors. Histopathology was inconclusive in 10.9% cases. Complication rate was 4.3%: one tract hematoma and one new neurological deficit. Frameless neuronavigation guided biopsy of intracranial space occupying lesion is safe and efficacious procedure with high diagnostic yield.

scholarly journals Diagnostic and Complication Rate of Image-guided Lung Biopsies in Raigmore Hospital, Inverness: A Retrospective Re-audit

2012 ◽  
Vol 1 (1) ◽  
pp. 1-7
Author(s):  
S Khadka
Keyword(s):  
Complication Rate ◽  
Large Scale ◽  
Histological Study ◽  
British Thoracic Society ◽  
Chest Drain ◽  
Imaging Method ◽  
Ct Guided ◽  
Image Guided ◽  
Bronchoscopic Biopsy ◽  
Lung Biopsies

Background: Suspected lung malignancies that are deemed inaccessible by bronchoscopic biopsy undergo image-guided biopsies to obtain samples for histological study. A previous audit performed in 2008 assessed the diagnostic and complication rate of computed tomography (CT)-guided lung biopsies. This retrospective re-audit aimed to reassess the lung biopsies done in 2010. Standards: British thoracic society guidelines for Radiologically guided lung biopsy. Materials and Method: All patients who underwent image-guided lung biopsies at Raigmore Hospital, Inverness, in 2010 were included in the study. The imaging was either CT or ultrasound (US) and either fine-needle aspirate or core-biopsy samples were collected. Information on diagnostic rate, complications such as pneumothorax and haemoptysis, age, sex, size and depth of lesion were collected. Results: 108 biopsies were obtained by image guided lung biopsies from 101 patients during 2010. 80 lesions were malignant, 19 were benign and 2 undiagnostic. 7 biopsies had to be repeated. Diagnostic accuracy was 91.7% (99 biopsies). 21 patients (19.4%) had pneumothorax. 19 suffered from small pneumothorax while 2 (1.9%) required chest drain. 7 patients (6.5%) developed minor haemoptysis. Only 3 out of 108 biopsies were done under US scan. Conclusion: The diagnostic and pneumothorax rates are well within British thoracic society guidelines, whilst the minor haemoptysis rate is slightly higher. Further large-scale studies are indicated to assess the possible role of ultrasound as a potential imaging method for pleural based lung biopsies. DOI: http://dx.doi.org/10.3126/njr.v1i1.6315 Nepalese Journal of Radiology Vol.1(1): 1-7

scholarly journals 562 Biopsy of Localised Renal Masses Offers High Diagnostic Yield and Low Complication Rate in Patients with Suspicious Renal Masses

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
J Ng Cheong Chung ◽  
G Isgro ◽  
T Page ◽  
D Thomas ◽  
P Haslam ◽  
...  
Keyword(s):  
Complication Rate ◽  
Renal Mass ◽  
Detection Rate ◽  
Diagnostic Yield ◽  
Tumour Size ◽  
Renal Masses ◽  
High Diagnostic Yield ◽  
Tertiary Centre ◽  
Renal Mass Biopsy ◽  
Benign Histology

Abstract Aim Biopsy of localised renal masses is generally accurate at detecting benign or malignant histology but can cause complications. The aim of this study was to determine the detection rate and complication rate of renal mass biopsies. Method Patients undergoing a renal mass biopsy at a single tertiary centre between January 2015 and December 2019 were identified electronically using a prospective database. Details about their biopsies were recorded including tumour size, radiological guidance, number of cores, longest margin of biopsy, accuracy of biopsy, histology type, and complications. Results This study included 334 biopsies (Median age 68 years (IQR 60-72); 61.4% (n = 204) male). Median size of tumour was 30mm (IQR 25-50) and 79.9% (n = 267) were solid masses. The biopsies were done under ultrasound (78.4%) or computed tomography (21.6%) guidance. 91.9% had core biopsies (n = 307) with median biopsy margin of 14mm (IQR 9-21). Benign histology was observed in 18.9% (n = 63), malignant in 72.1% (n = 241) while biopsy was non-diagnostic in 9.0% (n = 30). 62.6% (n = 209) of the cases were renal cell carcinoma with clear cell subtype more commonly seen (72.2%, n = 151). Complications following biopsy included haematoma (n = 7, 2.1%), haemorrhage (n = 3, 0.9%), pneumothorax (n = 1, 0.3%) and vasovagal episode (n = 1, 0.3%), resulting in an overall complication rate of 3.6%. Conclusions Biopsy of localised renal masses in this study showed a detection rate of 91% and complication rate of 3.6%. This study suggests renal mass biopsies have high diagnostic yield and low complication rate.

scholarly journals Diagnostic yield of CT-guided lung biopsies: how can we limit negative sampling?

2021 ◽  
Author(s):  
Marcello Andrea Tipaldi ◽  
Edoardo Ronconi ◽  
Miltiadis E Krokidis ◽  
Aleksejs Zolovkins ◽  
Gianluigi Orgera ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Lung Biopsy ◽  
Diagnostic Yield ◽  
Imaging Features ◽  
Technical Success ◽  
Ct Guided ◽  
Fdg Uptake ◽  
Increased Risk ◽  
Ct Guided Biopsy ◽  
Lung Biopsies

Objectives: To investigate whether lesion imaging features may condition the outcome of CT-guided Lung Biopsy (CTLB) and to develop a scoring system of biopsy outcome prediction. Methods: This is a single center retrospective study on 319 CTLBs that were performed in 319 patients (167 males/ 152 females, mean age 68 ± 12.2). Uni- and multivariate analysis were performed aiming to assess the imaging features that are likely to be corelated to a negative biopsy outcome and patients were stratified in groups accordingly. Results: Technical success was 100%. 78% of the biopsies (250/319) led to a concrete histology report (218 malignant/ 32 benign). The remaining lesions led to concrete histology at a second attempt that occurred on a later time. Multivariate analysis revealed increased risk of inconclusive result for nodules with low FDG uptake (OR = 2.64, 95% CI 1.4–4.97; p = 0.003), for nodules with diameter smaller than 18 mm (OR = 2.03, 95% CI 1.14–3.62; p = 0.017) and for nodules that are located in one of the lung bases (OR = 1.96, 95% CI 1.06–3.62; p = 0.033). Three different groups of patients were identified accordingly with low (<30%), medium (30–50%) and high (>50%) probability of obtaining an inconclusive biopsy sample. Conclusions: This study confirms that percutaneous CT guided biopsy in nodules that are either small in diameter or present low PET-FDG uptake or are in one of the lung bases may lead to inconclusive histology. This information should be factored when planning percutaneous biopsies of such nodules in terms of patient informed consent and biopsy strategy. Advances in knowledge: Inconclusive histology after lung biopsy may be subject to factors irrelevant to technical success. Lung biopsy histology outcomes may be predicted and avoided after adequate planning

scholarly journals Diagnostic yield of percutaneous computed tomography guided core needle biopsy of lung lesion and its complications in tertiary hospital

2020 ◽  
Vol 8 (12) ◽  
pp. 4223
Author(s):  
Prakash Kayastha ◽  
Binaya Adhikari ◽  
Sundar Suwal ◽  
Benu Lohani ◽  
Sharma Paudel
Keyword(s):  
Computed Tomography ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Lung Biopsy ◽  
Diagnostic Yield ◽  
Lung Lesion ◽  
Ct Guided ◽  
Core Needle ◽  
Lung Lesions ◽  
Image Guided

Background: Early diagnosis of lung cancer can reduce its mortality and morbidity. Minimally invasive image guided percutaneous core needle biopsy can obtain tissue sample for diagnosis and staging of lung cancer, which is crucial for correct management of lung lesions. Common complications of lung biopsy include pneumothorax, parenchymal haemorrhage and haemoptysis. The study was aimed to determine diagnostic yield and complications of the percutaneous computed tomography (CT) guided core needle biopsy of lung lesion in tertiary hospital.Methods: Hospital based prospective study was performed in 40 patients in Tribhuvan University Teaching Hospital. CT guided biopsy of lung lesions was performed with 18-gauge semi-automated biopsy instrument. The complications following the biopsy were recorded and correlated with different factors using chi-square test. Histopathology report were obtained to measure the diagnostic yield.Results: Among 40 patients who underwent guided lung biopsy, histopathology showed definitive diagnosis in 37 patients; 31 malignant and 6 benign lesions. Parenchymal haemorrhage, pneumothorax and haemoptysis were seen in 13, 8 and 5 respectively; however, none required active intervention. Emphysema in traversing lung and numbers of pleural punctures used were predictive factors of complication (p value <0.05).Conclusions: The study showed percutaneous image guided core needle biopsy has high diagnostic yield with fewer complication rates and is thus recommended for routine biopsies of lung lesions.

scholarly journals Yield of ultrasound guided transthoracic needle aspiration in peripheral intrathoracic mass lesions

2021 ◽  
Vol 6 (2) ◽  
pp. 105-110
Author(s):  
Sajitha M ◽  
P Sukumaran ◽  
K P Venugopal ◽  
Jayakumar T K
Keyword(s):  
Complication Rate ◽  
Diagnostic Yield ◽  
Needle Aspiration ◽  
Safe Procedure ◽  
Ultrasound Guided ◽  
Ct Guided ◽  
High Diagnostic Yield ◽  
Therapeutic Decisions ◽  
Intrathoracic Mass ◽  
Mass Lesions

In thoracic lesions, early diagnosis and sorting out into malignant- benign is important regarding the therapeutic decisions and prognosis. Ultrasound guided Transthoracic needle aspiration (TTNA) and Corebiopsy (CNB) are described to be safe accurate high yielding means of diagnosis. The study aims to determine the yield and safety of TTNA in peripheral intrathoracic mass lesions. Study was conducted in government teaching institution in Kerala. Patients with intrathoracic peripheral mass lesions which were visualized by USG were subjected to TTNA, and sent for cytopathology. The patients with inconclusive results were subjected to either USG guided or CT guided CNB. The patients were followed up till a conclusive diagnosis obtained. The results were classified as conclusive /definitive or inconclusive. Diagnostic yield and complication rate calculated.USG guided TTNA had an overall diagnostic yield of 65.5%,with 72.15% yield in malignancy. It had high diagnostic yield in lung carcinoma(82.3%) and was a safe procedure with complication rate of 3% only.Combined with USG guided CNB, the overall yield became 86.66% with a cumulative yield of 91.13% in malignancy with no increase in complication rate. Ultrasound guided TTNA is a safe procedure with good yield in peripheral lung malignancies.Ultrasound guided transthoracic needle aspiration and core cut together has a high diagnostic yield in peripheral intrathoracic masses and is accurate in differentiating malignant and benign lesion with a good safety profile.

Do Immunocompromised Children Benefit from Having Surgical Lung Biopsy Performed?

2014 ◽  
Vol 133 (2) ◽  
pp. 205-209 ◽  
Author(s):  
Gal Goldstein ◽  
Nathan Keller ◽  
Ron Bilik ◽  
Bella Bielorai ◽  
Amos Toren
Keyword(s):  
Lung Biopsy ◽  
Diagnostic Yield ◽  
Hematologic Malignancy ◽  
Major Complication ◽  
Surgical Lung Biopsy ◽  
Diagnostic Biopsy ◽  
Preoperative Factor ◽  
Lung Biopsies ◽  
Clinical Records ◽  
The Impact

Background: Surgical lung biopsy is considered a gold standard for the evaluation of pulmonary disease in immunocompromised children. However, in the literature, its accuracy and the rate of complications vary. Objective: We aimed to evaluate the yield of surgical lung biopsies in the management of persistent pulmonary findings in immunocompromised children. Methods: We performed a retrospective review of clinical records of immunocompromised children who underwent surgical lung biopsies, and evaluated the impact that preoperative factors had on outcomes. Results: Twenty-five patients underwent 27 surgical lung biopsies. The underlying immunodeficiency included allogeneic stem cell transplantation (n = 12), chemotherapy for solid tumors (n = 6), hematologic malignancy (n = 4), primary immunodeficiency (n = 4) and chronic steroid use (n = 1). Biopsies provided a specific histopathologic or microbiologic diagnosis in 10 cases (37%). No preoperative factor predicted a diagnostic biopsy. Five of the 27 biopsies were beneficial for the patients (18%). A major complication related to the procedure was reported for 1 biopsy (4%). Conclusions: We conclude that surgical lung biopsy in pediatric immunocompromised patients appears to be safe, but has a relatively low diagnostic yield and an even lower yield with regards to the benefit it provides. © 2014 S. Karger AG, Basel

Sign in / Sign up

Export Citation Format

Share Document