Geringgradige Hirnblutungen bei Frühgeborenen: Prognose scheint günstig

2017 ◽  
Vol 221 (06) ◽  
pp. 263-264
Keyword(s):  
Preterm Infants ◽  
Intraventricular Hemorrhage ◽  
Neurodevelopmental Outcome ◽  
Low Grade ◽  
Germinal Matrix ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
The Impact

Reubsaet P et al. The Impact of Low-Grade Germinal Matrix-Intraventricular Hemorrhage on Neurodevelopmental Outcome of Very Preterm Infants. Neonatology 2017; 112: 203–210 Bei Frühgeborenen sind Hirnblutungen eine nicht seltene Komplikation, und schwere Blutungen vom Grad III und Grad IV haben eine eher schlechte Prognose, was die spätere neurokognitive Entwicklung betrifft. Für geringgradige Blutungen vom Grad I und Grad II gibt es aber nur wenige Daten zur späteren Entwicklung. Mediziner aus Utrecht haben versucht, diese Lücke zu schließen.

scholarly journals The Impact of Low-Grade Germinal Matrix-Intraventricular Hemorrhage on Neurodevelopmental Outcome of Very Preterm Infants

Neonatology ◽  
2017 ◽  
Vol 112 (3) ◽  
pp. 203-210 ◽  
Author(s):  
Pauline Reubsaet ◽  
Annemieke J. Brouwer ◽  
Ingrid C. van Haastert ◽  
Margaretha J. Brouwer ◽  
Corine Koopman ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Intraventricular Hemorrhage ◽  
Neurodevelopmental Outcome ◽  
Low Grade ◽  
Germinal Matrix ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
The Impact

scholarly journals Low-grade intraventricular hemorrhage and neurodevelopment at 24 months of age

2018 ◽  
Vol 28 (3) ◽  
pp. 29354
Author(s):  
Sara Peixoto ◽  
Joana Amaral ◽  
Cristina Resende ◽  
Dolores Faria ◽  
Adelaide Taborda
Keyword(s):  
Preterm Infants ◽  
Gestational Age ◽  
Intraventricular Hemorrhage ◽  
Univariate Analysis ◽  
Neurodevelopmental Outcome ◽  
Male Gender ◽  
Low Grade ◽  
Antenatal Corticosteroid ◽  
The Impact ◽  
Cranial Ultrasonography

AIMS: To evaluate the impact of low-grade intraventricular hemorrhage on neurodevelopmental outcome in preterm infants at 24 months of age.METHODS: We conducted a retrospective case-control study of infants with gestational age less than 34 weeks, admitted to a Neonatal Intensive Care Unit between January/2006 and December/2015. Cases were defined as those with low-grade intraventricular hemorrhage (grades I or II), diagnosed by cranial ultrasonography. For each case, a control with the same gestational age but without intraventricular hemorrhage was selected. Follow-up examinations of neurodevelopment were performed at 24 months of age in cases and controls using the Griffiths Mental Development Scale. Cerebral palsy, neurodevelopmental delay (developmental quotient <2 side deviations below the mean), hearing impairment and/or blindness were considered as severe neurodevelopmental impairment.RESULTS: The study included 172 preterm infants: 86 cases and 86 controls. In the univariate analysis, a difference between the two groups was identified for the following clinical findings: antenatal corticosteroid complete cycle (57% in cases vs. 80% in controls; p=0.001; OR: 0.33, 95%CI 0.17-0.64); male gender (63% cases vs. 41% controls; p=0.004; OR: 2.45, 95%CI 1.3-4.5); outborn (26% cases vs. 9% controls; p=0.005; OR: 3.3 95%CI 1.4-8.0); Clinical Risk Index for Babies higher than 5 (24% in cases vs. 12% in controls; p=0.029; OR: 2.4 95%CI 1.1-5.6); intubation in the delivery room (47% cases vs. 27% controls; p=0.007; OR: 2.38 95%CI 1.3-4.5); and neonatal sepsis (34% in cases vs. 20% in controls; p=0.039; OR: 2.1 95%CI 1.03-4.1). After logistic regression, differences were only maintained for antenatal corticosteroid (p=0.005; OR 0.34, 95%CI 0.16-0.72) and male gender (p=0.002; OR 2.9, 95%CI 1.4-5.8). A severe neurodevelopmental deficit was present in three cases (3.5%) and one control (1.2%). No statistically significant differences in outcome were found between cases and controls.CONCLUSIONS: In this sample, preterm infants with low-grade intraventricular hemorrhage diagnosed by cranial ultrasonography had no difference in early neurodevelopmental outcome when compared with controls.

scholarly journals Consensus Approach for Standardizing the Screening and Classification of Preterm Brain Injury Diagnosed With Cranial Ultrasound: A Canadian Perspective

2021 ◽  
Vol 9 ◽  
Author(s):  
Khorshid Mohammad ◽  
James N. Scott ◽  
Lara M. Leijser ◽  
Hussein Zein ◽  
Jehier Afifi ◽  
...  
Keyword(s):  
Brain Injury ◽  
White Matter ◽  
Preterm Infants ◽  
Intraventricular Hemorrhage ◽  
White Matter Injury ◽  
Cranial Ultrasound ◽  
Consensus Approach ◽  
Germinal Matrix ◽  
Very Preterm Infants ◽  
Very Preterm

Acquired brain injury remains common in very preterm infants and is associated with significant risks for short- and long-term morbidities. Cranial ultrasound has been widely adopted as the first-line neuroimaging modality to study the neonatal brain. It can reliably detect clinically significant abnormalities that include germinal matrix and intraventricular hemorrhage, periventricular hemorrhagic infarction, post-hemorrhagic ventricular dilatation, cerebellar hemorrhage, and white matter injury. The purpose of this article is to provide a consensus approach for detecting and classifying preterm brain injury to reduce variability in diagnosis and classification between neonatologists and radiologists. Our overarching goal with this work was to achieve homogeneity between different neonatal intensive care units across a large country (Canada) with regards to classification, timing of brain injury screening and frequency of follow up imaging. We propose an algorithmic approach that can help stratify different grades of germinal matrix-intraventricular hemorrhage, white matter injury, and ventricular dilatation in very preterm infants.

scholarly journals Intraventricular Hemorrhage in Very Preterm Infants: A Comprehensive Review

2020 ◽  
Vol 9 (8) ◽  
pp. 2447
Author(s):  
Vianney Gilard ◽  
Abdellah Tebani ◽  
Soumeya Bekri ◽  
Stéphane Marret
Keyword(s):  
Preterm Infants ◽  
Intraventricular Hemorrhage ◽  
Literature Search ◽  
Preterm Births ◽  
Predictive Biomarkers ◽  
Intraparenchymal Hemorrhage ◽  
Comprehensive Overview ◽  
Germinal Matrix ◽  
Very Preterm Infants ◽  
Very Preterm

Germinal matrix-intraventricular-intraparenchymal hemorrhage (GMH-IVH-IPH) is a major complication of very preterm births before 32 weeks of gestation (WG). Despite progress in clinical management, its incidence remains high before 27 WG. In addition, severe complications may occur such as post-hemorrhagic hydrocephalus and/or periventricular intraparenchymal hemorrhage. IVH is strongly associated with subsequent neurodevelopmental disabilities. For this review, an automated literature search and a clustering approach were applied to allow efficient filtering as well as topic clusters identification. We used a programmatic literature search for research articles related to intraventricular hemorrhage in preterms that were published between January 1990 and February 2020. Two queries ((Intraventricular hemorrhage) AND (preterm)) were used in PubMed. This search resulted in 1093 articles. The data manual curation left 368 documents that formed 12 clusters. The presentation and discussion of the clusters provide a comprehensive overview of existing data on the pathogenesis, complications, neuroprotection and biomarkers of GMH-IVH-IPH in very preterm infants. Clinicians should consider that the GMH-IVH-IPH pathogenesis is mainly due to developmental immaturity of the germinal matrix and cerebral autoregulation impairment. New multiomics investigations of intraventricular hemorrhage could foster the development of predictive biomarkers for the benefit of very preterm newborns.

scholarly journals The Impact of Neonatal Morbidities on Smooth Pursuit Eye Movements in Very Preterm Infants

2011 ◽  
Vol 70 ◽  
pp. 352-352 ◽  
Author(s):  
K Strand Brodd ◽  
K Rosander ◽  
H Grönqvist ◽  
G Holmström ◽  
B Strömberg ◽  
...  
Keyword(s):  
Eye Movements ◽  
Preterm Infants ◽  
Smooth Pursuit ◽  
Smooth Pursuit Eye Movements ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Pursuit Eye Movements ◽  
The Impact

Cerebral Oxygenation, Extraction, and Autoregulation in Very Preterm Infants Who Develop Peri-Intraventricular Hemorrhage

2013 ◽  
Vol 162 (4) ◽  
pp. 698-704.e2 ◽  
Author(s):  
Thomas Alderliesten ◽  
Petra M.A. Lemmers ◽  
Janneke J.M. Smarius ◽  
René E. van de Vosse ◽  
Willem Baerts ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Intraventricular Hemorrhage ◽  
Cerebral Oxygenation ◽  
Very Preterm Infants ◽  
Very Preterm

scholarly journals Circulatory insulin-like growth factor-I and brain volumes in relation to neurodevelopmental outcome in very preterm infants

2013 ◽  
Vol 74 (5) ◽  
pp. 564-569 ◽  
Author(s):  
Ingrid Hansen-Pupp ◽  
Holger Hövel ◽  
Chatarina Löfqvist ◽  
Lena Hellström-Westas ◽  
Vineta Fellman ◽  
...  
Keyword(s):  
Growth Factor ◽  
Preterm Infants ◽  
Neurodevelopmental Outcome ◽  
Insulin Like Growth Factor ◽  
Brain Volumes ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Factor I ◽  
Growth Factor I
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