A hydrophobic cluster in the center of the third extracellular loop is important for TSH receptor signaling

2006 ◽  
Vol 114 (S 1) ◽  
Author(s):  
M Claus ◽  
H Jäschke ◽  
G Kleinau ◽  
S Neumann ◽  
G Krause ◽  
...  
Keyword(s):  
Tsh Receptor ◽  
Receptor Signaling ◽  
Extracellular Loop ◽  
The Third ◽  
Hydrophobic Cluster

scholarly journals A Hydrophobic Cluster in the Center of the Third Extracellular Loop Is Important for Thyrotropin Receptor Signaling

Endocrinology ◽  
2005 ◽  
Vol 146 (12) ◽  
pp. 5197-5203 ◽  
Author(s):  
Maren Claus ◽  
Holger Jaeschke ◽  
Gunnar Kleinau ◽  
Susanne Neumann ◽  
Gerd Krause ◽  
...  
Keyword(s):  
Receptor Signaling ◽  
Thyrotropin Receptor ◽  
Extracellular Loop ◽  
The Third ◽  
Hydrophobic Cluster

scholarly journals A Region Within the Third Extracellular Loop of Rat AQP6 Precludes Its Trafficking to Plasma Membrane in a Heterologous Cell Line.

2021 ◽  
Author(s):  
David Soler ◽  
Thomas Kowatz ◽  
Andrew Sloan ◽  
Thomas McCormick ◽  
Kevin Cooper ◽  
...  
Keyword(s):  
Amino Acids ◽  
Plasma Membrane ◽  
Membrane Protein ◽  
Cell Line ◽  
Membrane Trafficking ◽  
Extracellular Loop ◽  
Reporter System ◽  
The Third ◽  
Heterologous Cell ◽  
Retention Signal

Abstract The inability to over-express AQP6 in the plasma membrane of heterologous cells has hampered efforts to further characterize the function of this aquaglyceroporin membrane protein at atomic detail. Using the AGR reporter system we have identified a region within loop C of AQP6 that is responsible for severely hampering its plasma membrane localization. Serine substitution corroborated that amino acids present within AQP6194-213 of AQP6 loop C contribute to intracellular retention. This intracellular retention signal may preclude proper plasma membrane trafficking and severely curtail expression of AQP6 in heterologous cells.

scholarly journals TSH Receptor Signaling Abrogation by a Novel Small Molecule

2016 ◽  
Vol 7 ◽  
Author(s):  
Rauf Latif ◽  
Ronald B. Realubit ◽  
Charles Karan ◽  
Mihaly Mezei ◽  
Terry F. Davies
Keyword(s):  
Small Molecule ◽  
Tsh Receptor ◽  
Receptor Signaling

K660 in the 3. extracellular loop of the TSH receptor is important for G-protein mediated signaling

2004 ◽  
Vol 112 (S 1) ◽  
Author(s):  
H Jäschke ◽  
G Kleinau ◽  
G Krause ◽  
R Paschke ◽  
S Neumann
Keyword(s):  
G Protein ◽  
Tsh Receptor ◽  
Extracellular Loop
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