Can EUS Help Differentiate Macrocystic Serous Cystadenomas from Mucinous Cystadenomas of the Pancreas by Its Morphologic Characteristics?

AbstractPancreatic cysts involve a wide spectrum of pathologies from post-inflammatory cysts to malignant neoplasms. Pancreatic pseudocysts, serous cystadenomas, mucinous cystadenomas, intraductal papillary mucinous neoplasms (IPMNs) and solid pseudopapillary tumors occur most frequently. Differential diagnosis involves the following imaging investigations: transabdominal ultrasonography (TUS), contrast enhanced ultrasonography (CEUS) and endoscopic ultrasonography (EUS), computed tomography (CT), magnetic resonance (MR) and magnetic resonance cholangiopancretography (MRCP), endoscopic retrograde cholangiopancretography (ERCP). The cyst fluid cytology is performed in difficult differential diagnosis between pseudocysts and benign and potentially malignant or malignant tumors. Most frequently, viscosity, amylase, CEA and CA 19-9 levels are determined. Imaging findings should be correlated with cytology. The management depends on the cyst type and size. Small asymptomatic pseudocysts, serous cystadenomas and branchduct IPMNs should be carefully observed, whereas symptomatic large or uncertain serous cystadenomas and cystadenocarcinomas, mucinous cystadenomas and cystadenocarcinomas, main-duct IPMNs and large branch-duct IPMNs with malignant features, serous and mucinous cystadenocarcinomas, and solid pseudopapillary tumors require surgery. Pseudocysts are usually drained. Percutaneous / EUS-guided or surgical cyst drainage can be performed. Complicated and uncertain pseudocysts and cystic tumors need surgical resection. The type of surgery depends on cyst location and size and includes proximal, central, distal, total pancreatectomies and enucleation.

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Differential Diagnosis of Pancreatic Serous Cystadenomas and Mucinous Cystadenomas: Utility of Texture Analysis in Combination with Morphological Characteristics

10.21203/rs.2.13612/v1 ◽

2019 ◽

Author(s):

Jing Yang ◽

Xinli Guo ◽

Weiwei Zhang ◽

Jinen Song ◽

Xuelei Ma ◽

...

Keyword(s):

Differential Diagnosis ◽

Receiver Operating Characteristic ◽

Texture Analysis ◽

Operating Characteristic ◽

Morphological Characteristics ◽

Textural Features ◽

Reliable Technique ◽

Serous Cystadenomas ◽

Mucinous Cystadenomas ◽

Receiver Operating

Abstract Background Texture analysis of medical images has been reported to be a reliable technique for differential diagnosis of neoplasms. This study was to investigate the performance of textural features and the combined performance of textural features and morphological characteristics in the differential diagnosis of pancreatic serous and mucinous cystadenomas. Methods We retrospectively reviewed 59 patients with pancreatic serous cystadenoma and 32 patients with pancreatic mucinous cystadenoma at our hospital. Textural features were extracted using the LifeX software, and the least absolute shrinkage and selection operator (LASSO) method was applied to select the textural features. The differential diagnostic abilities of morphological features, textural features, and their combination were evaluated using receiver operating characteristic (ROC) analysis, with the area under the receiver operating characteristic curve (AUC) as the main indicator. Results The combination of morphological characteristics and textural features showed a higher AUC (0.893, 95% CI 0.816-0.970) than use of morphological characteristics (0.783, 95% CI 0.665-0.900) or textural features (0.777, 95% CI 0.673-0.880) alone. Conclusions In conclusion, our preliminary results highlighted the potential of CT texture analysis to discriminate pancreatic serous cystadenomas from mucinous cystadenomas. Furthermore, the combination of morphological and textural features can significantly improve the diagnostic performance, which may provide a reliable method to select patients with indication of surgical intervention in consideration of the different treatment principles of the two diseases.

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Ovarian cysts in Pregnancy: Obstetric Outcome and Management

PERSPECTIVES IN MEDICAL RESEARCH - 2 ◽

10.47799/pimr.0901.14 ◽

2021 ◽

Vol 9 (1) ◽

pp. 69-73

Author(s):

Greeshma Singham ◽

Vivekanand Achanta ◽

Satyaprabha Siripurapu Siripurapu ◽

Ipsita Mohapatra Mohapatra

Keyword(s):

Cesarean Section ◽

Pregnancy Outcome ◽

Histopathological Examination ◽

Spontaneous Resolution ◽

Ovarian Cysts ◽

Medical Sciences ◽

Simple Cyst ◽

Emergency Cesarean ◽

Serous Cystadenomas ◽

Mucinous Cystadenomas

Objective: To study the pregnancy outcome and management of ovarian cysts during pregnancy. Methods : A prospective observational study was conducted in Prathima Institute of Medical Sciences, Karimnagar from June 2018 to June 2020. A total of 32 cases with ovarian cysts 5cm with benign features as suggested by ultrasound were included in the study. The pregnancy outcome and management were studied. Results : Out of 32 pregnant women with ovarian cysts, 25(78.12%) were asymptomatic and were managed conservatively. Of the 25, spontaneous resolution was seen in 18(56.25%) patients while 7(21.87%) patients in whom ovarian cyst persisted or was incidentally detected during cesarean section were managed by cystectomy at the same time. Surgery was needed in the antenatal period in 7(21.87%) patients due to complications such as increase in size of the cyst seen in 4(12.5%) and torsion seen in 3(9.37%). All the 32 patients had good perinatal outcome. There were no miscarriages. All patients continued to term except one, who presented at 36 weeks with torsion, andunderwent emergency cesarean section with oophorectomy. Histopathological examination of the excised cysts showed 5 as simple cyst, 5 as serous cystadenomas, 3 as mucinous cystadenomas and 1 as dermoid. Conclusion: Management of the ovarian cysts during pregnancy is conservative. Most of them undergo spontaneous resolution. Surgical management is reserved for only symptomatic patients. Pregnancy outcome as such is not affected by ovarian cysts during pregnancy.

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Cystic Neoplasms of the Exocrine Pancreas

HPB Surgery ◽

10.1155/1990/24762 ◽

1990 ◽

Vol 2 (3) ◽

pp. 165-175 ◽

Cited By ~ 2

Author(s):

F. Mosimann ◽

C. Ribaux ◽

P. Schnyder

Keyword(s):

Computed Tomography ◽

Exocrine Pancreas ◽

Mucinous Cystadenoma ◽

Preoperative Assessment ◽

Serous Cystadenoma ◽

Cystic Neoplasms ◽

Serous Cystadenomas ◽

Histological Variants ◽

Potentially Malignant ◽

Mucinous Cystadenomas

Cystic neoplasms of the pancreas are rare and their diagnosis and treatment can be difficult. This report details 7 patients who had histologically proven serous cystadenoma4, mucinous cystadenoma2 and cystadeno carcinoma1. Computed tomography and sonography allowed excellent preoperative assessment but to attempt a distinction between the histological variants may be hazardous. Two tumours were only autopsy findings and 5 patients underwent laparotomy. It is confirmed that potentially malignant mucinous cystadenomas and cytadenocarcinomas should be resected whenever possible; serous cystadenomas are always benign and should therefore be resected only when the diagnosis is doubtful or if they cause symptoms.

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Discrimination of Pancreatic Serous Cystadenomas From Mucinous Cystadenomas With CT Textural Features: Based on Machine Learning

Frontiers in Oncology ◽

10.3389/fonc.2019.00494 ◽

2019 ◽

Vol 9 ◽

Cited By ~ 13

Author(s):

Jing Yang ◽

Xinli Guo ◽

Xuejin Ou ◽

Weiwei Zhang ◽

Xuelei Ma

Keyword(s):

Machine Learning ◽

Textural Features ◽

Serous Cystadenomas ◽

Mucinous Cystadenomas

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Cytoplasmic Tubules in Cells Infected with Laryngotracheitis Virus

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100063792 ◽

1969 ◽

Vol 27 ◽

pp. 376-377

Author(s):

A. M. Watrach

Keyword(s):

Tissue Culture ◽

Small Proportion ◽

Chicken Embryo ◽

Culture Cells ◽

Tissue Culture Cells ◽

Morphologic Characteristics ◽

Infectious Laryngotracheitis ◽

Laryngotracheitis Virus ◽

In Cells

During a study of the development of infectious laryngotracheitis (LT) virus in tissue culture cells, unusual tubular formations were found in the cytoplasm of a small proportion of the affected cells. It is the purpose of this report to describe the morphologic characteristics of the tubules and to discuss their possible association with the development of virus.The source and maintenance of the strain of LT virus have been described. Prior to this study, the virus was passed several times in chicken embryo kidney (CEK) tissue culture cells.

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Medial Smooth Muscle Cell Proliferation in the Balloon Injured Rabbit Aorta: Effect of a Thiazole Compound with Platelet Inhibitory Activity

Thrombosis and Haemostasis ◽

10.1055/s-0038-1661024 ◽

1984 ◽

Vol 51 (01) ◽

pp. 075-078 ◽

Cited By ~ 8

Author(s):

R G Schaub ◽

C A Simmons

Keyword(s):

Smooth Muscle ◽

Platelet Aggregation ◽

Balloon Catheter ◽

Rabbit Aorta ◽

Surface Characteristics ◽

Inhibitory Effect ◽

Lesion Size ◽

Blue Staining ◽

Morphologic Characteristics ◽

Time Period

SummaryTwenty-seven adult male New Zealand rabbits (3–4 kgs) were used in this study. Six rabbits received vehicle, 3 groups of 6 each received doses of 4,5-bis(p-methoxyphenyl)-2-(trifluoromethyl)- thiazole, (U-53,059), at 0.3 mg/kg, 3.0 mg/kg and 30.0 mg/kg/day respectively. Drug and vehicle doses were given orally each day starting 3 days before balloon injury and continuing for the entire 2 week time period. Three rabbits were used as nontreated sham controls. In the vehicle and U-53,059 treated groups aortae were denuded of endothelial cells by balloon catheter injury. Two weeks after injury platelet aggregation to collagen was measured and the aortae removed for analysis of surface characteristics by scanning electron microscopy and lesion size by morphometry. All doses of U-53,059 inhibited platelet aggregation. The 3.0 and 30.0 mg/kg groups had the greatest inhibitory effect. All balloon injured aortae had the same morphologic characteristics. All vessels had similar extent and intensity of Evan’s blue staining, similar areas of leukocyte/platelet adhesion, and a myointimal cell cover of transformed smooth muscle cells. The myointimal proliferative response was not inhibited at any of the drug doses studied.

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