Clonal Priming of Lymphocytes Can Measure Human Immune-Response Gene Function

1977 ◽  
Vol 297 (15) ◽  
pp. 842-843 ◽  
Keyword(s):  
Immune Response ◽  
Gene Function ◽  
Immune Response Gene ◽  
Response Gene ◽  
Human Immune Response ◽  
Human Immune

Determinant Selection vs Clonal Deletion Models of Immune Response Gene Function

Ir Genes ◽  
1983 ◽  
pp. 251-261
Author(s):  
George A. Dos Reis ◽  
Robert B. Clark ◽  
Ethan M. Shevach
Keyword(s):  
Immune Response ◽  
Gene Function ◽  
Immune Response Gene ◽  
Clonal Deletion ◽  
Response Gene

scholarly journals The xid gene controls Ia.W39-associated immune response gene function.

1981 ◽  
Vol 153 (5) ◽  
pp. 1113-1123 ◽  
Author(s):  
L J Rosenwasser ◽  
B T Huber
Keyword(s):  
Immune Response ◽  
Gene Function ◽  
Immune Response Gene ◽  
T Cell Proliferation ◽  
Response Gene ◽  
Histocompatibility Complex ◽  
Ia Antigens ◽  
Antigen Presenting ◽  
Ir Genes

Immune response (Ir) genes are encoded for by the I region of the major histocompatibility complex (MHC). A class of serologically defined specificities, Ia antigens, is also encoded for by genes within this region. A new Ia specificity, Ia.W39, has recently been defined. It is private for I-Ab and its expression is controlled by a gene on the X-chromosome. Using different approaches, the role of Ia.W39 in the immune response of H-2b mice to beef insulin was examined in a macrophage-dependent T cell proliferation assay. It was found that beef insulin-related Ir gene function was associated with the expression of Ia.W39 by antigen-presenting macrophages and that control of this Ir gene function was X-linked (xid gene).

DETERMINANT SELECTION: A MACROPHAGE-MEDIATED IMMUNE RESPONSE GENE FUNCTION

1978 ◽  
pp. 405-415 ◽  
Author(s):  
Alan S. Rosenthal ◽  
Lanny J. Rosenwasser ◽  
Marcello A. Barcinski
Keyword(s):  
Immune Response ◽  
Gene Function ◽  
Immune Response Gene ◽  
Response Gene

scholarly journals Antigen-presenting cells from nonresponder strain 2 guinea pigs are fully competent to present bovine insulin B chain to responder strain 13 T cells. Evidence against a determinant selection model and in favor of a clonal deletion model of immune response gene function.

1983 ◽  
Vol 157 (4) ◽  
pp. 1287-1299 ◽  
Author(s):  
G A Dos Reis ◽  
E M Shevach
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Gene Function ◽  
Guinea Pigs ◽  
Bovine Insulin ◽  
Immune Response Gene ◽  
Cell Repertoire ◽  
Clonal Deletion ◽  
Response Gene ◽  
Selection Hypothesis

To test directly the determinant selection hypothesis of immune response gene function, we primed strain 13 T lymphocytes in vitro with allogeneic bovine insulin pulsed strain 2 macrophages. Strain 2 macrophages were found to be fully competent to present bovine insulin B chain to strain 13 T cells despite the fact that strain 2 guinea pigs are normally totally unresponsive to this antigen. These results are incompatible with a strict interpretation of the determinant selection hypothesis, which would have predicted that strain 2 macrophages would have been restricted to the presentation of A chain loop determinants. In addition, a comparison of the reactivity profiles of self-Ia- and allo-Ia-restricted strain 13 T cells to a series of synthetic B chain peptide fragments revealed that the allo-Ia-restricted populations could be activated by autologous guinea pig insulin. Taken together, these observations strongly suggest that the clonal deletion of self-reactive cells is likely to be I region restricted and that nonresponsiveness to any protein antigen may result from a restriction in the T cell repertoire that is generated during ontogeny by a clonal deletion mechanism of tolerance to self.

Thymic immune response gene function in radiation chimeras reconstituted with purified hemopoietic stem cells

1987 ◽  
Vol 17 (4) ◽  
pp. 471-475 ◽  
Author(s):  
W. Martin Kast ◽  
Arie C. Voordouw ◽  
Tine Leupers ◽  
Jan W. M. Visser ◽  
Cornelis J. M. Melief
Keyword(s):  
Stem Cells ◽  
Immune Response ◽  
Gene Function ◽  
Immune Response Gene ◽  
Hemopoietic Stem Cells ◽  
Response Gene ◽  
Radiation Chimeras

scholarly journals B lymphocyte immune response gene phenotype is genetically determined.

1982 ◽  
Vol 155 (4) ◽  
pp. 1239-1244
Author(s):  
H Y Tse ◽  
J J Mond ◽  
D L Longo
Keyword(s):  
Immune Response ◽  
T Cells ◽  
B Cells ◽  
B Cell ◽  
Gene Function ◽  
B Lymphocyte ◽  
Immune Response Gene ◽  
Cell Immune Response ◽  
Response Gene ◽  
Genetically Determined

We examined the effects of the developmental milieu on the capacity of B cells to undergo immune response gene-controlled, T cell-dependent polyclonal proliferation. Although I-Aq poly(Glu60 Ala30 Tyr10)n (GAT)-nonresponder T cells developing in a responder environment become phenotypic GAT-responders, I-Aq B cells remain unresponsive to GAT, even after maturation in a GAT-responder animal. Conversely, (B10.A x B10.Q)F1 ([GAT responder x GAT nonresponder]F1) T cells developing in a B10.Q GAT nonresponder host fail to respond to GAT, but F1 B cells from the same F1 leads to parent chimeras make excellent proliferative responses in the presence of GAT and responder T cells. Thus, by this assay, B cell immune response gene function is genetically determined and is not affected by the developmental milieu.

Determinant selection is a macrophage dependent immune response gene function

Nature ◽  
1977 ◽  
Vol 267 (5607) ◽  
pp. 156-158 ◽  
Author(s):  
ALAN S. ROSENTHAL ◽  
MARCELLO A. BARCINSKI ◽  
J. THOMAS BLAKE
Keyword(s):  
Immune Response ◽  
Gene Function ◽  
Immune Response Gene ◽  
Response Gene

scholarly journals Assessing the human immune response to SARS-CoV-2 variants

2021 ◽  
Vol 27 (4) ◽  
pp. 571-572 ◽  
Author(s):  
Roberto Burioni ◽  
Eric J. Topol
Keyword(s):  
Immune Response ◽  
Human Immune Response ◽  
Human Immune

scholarly journals Approaches to Modelling the Human Immune Response in Transition of Candidates from Research to Development

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Diane Williamson
Keyword(s):  
Immune Response ◽  
Human Immune Response ◽  
Human Immune ◽  
Animal Rule

This review considers the steps required to evaluate a candidate biodefense vaccine or therapy as it emerges from the research phase, in order to transition it to development. The options for preclinical modelling of efficacy are considered in the context of the FDA’s Animal Rule.

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