scholarly journals The xid gene controls Ia.W39-associated immune response gene function.

1981 ◽  
Vol 153 (5) ◽  
pp. 1113-1123 ◽  
Author(s):  
L J Rosenwasser ◽  
B T Huber
Keyword(s):  
Immune Response ◽  
Gene Function ◽  
Immune Response Gene ◽  
T Cell Proliferation ◽  
Response Gene ◽  
Histocompatibility Complex ◽  
Ia Antigens ◽  
Antigen Presenting ◽  
Ir Genes

Immune response (Ir) genes are encoded for by the I region of the major histocompatibility complex (MHC). A class of serologically defined specificities, Ia antigens, is also encoded for by genes within this region. A new Ia specificity, Ia.W39, has recently been defined. It is private for I-Ab and its expression is controlled by a gene on the X-chromosome. Using different approaches, the role of Ia.W39 in the immune response of H-2b mice to beef insulin was examined in a macrophage-dependent T cell proliferation assay. It was found that beef insulin-related Ir gene function was associated with the expression of Ia.W39 by antigen-presenting macrophages and that control of this Ir gene function was X-linked (xid gene).

Determinant Selection vs Clonal Deletion Models of Immune Response Gene Function

Ir Genes ◽  
1983 ◽  
pp. 251-261
Author(s):  
George A. Dos Reis ◽  
Robert B. Clark ◽  
Ethan M. Shevach
Keyword(s):  
Immune Response ◽  
Gene Function ◽  
Immune Response Gene ◽  
Clonal Deletion ◽  
Response Gene

scholarly journals Role of BoLA-DRB3 genetic diversity against resistance to mastitis in cattle: Review

2019 ◽  
pp. 30-36 ◽  
Author(s):  
Namita Kumari ◽  
Shubham Loat ◽  
Shallu Saini ◽  
Nitika Dhilor ◽  
Anurag Kumar ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Immune Response ◽  
Major Histocompatibility Complex ◽  
Immune Regulation ◽  
Peptide Antigens ◽  
Mhc Molecules ◽  
Histocompatibility Complex ◽  
Antigen Presenting ◽  
Jawless Fish

The major histocompatibility complex (MHC) is an organized cluster of tightly linked genes, present in all vertebrates, playing an important role in the immune system, except the jawless fish [1]. MHC was first identified during tissue transplantation studies in mice [2] and was first known for its role in histocompatibility. Consequently, the role of MHC was discovered in immune regulation [3] and several other functions [4,5]. The important function of the MHC is to code for specialized antigen-presenting receptor glycoproteins, also called as MHC molecules. The products of these genes are involved in the induction and regulation of immune response. These molecules bind processed peptide antigens and present them to T-lymphocytes, thereby triggering immune response.

scholarly journals Histocompatibility antigens and genetic control of the immune response in guinea pigs. III. Specific inhibition of antigen-induced lymphocyte proliferation by strain-specific anti-idiotypic antibodies.

1976 ◽  
Vol 144 (1) ◽  
pp. 226-240 ◽  
Author(s):  
A F Geczy ◽  
C L Geczy ◽  
A L de Weck
Keyword(s):  
Immune Response ◽  
Immune Cells ◽  
Inhibitory Activity ◽  
Guinea Pigs ◽  
Potential Role ◽  
T Cell Proliferation ◽  
Gene Products ◽  
Histocompatibility Complex

The in vitro T-cell proliferation induced by penicilloylated bovine IgG (BPO-BGG) in sensitized strain 2 and strain 13 guinea pigs could be specifically blocked by strain-specific antisera presumably directed against cell membrane-associated immunoglobulin idiotypes. The anti-idiotypic antisera were prepared in strain 2 and strain 13 guinea pigs against immunoadsorbent purified anti-BPO-BGG antibodies which had been raised in strain 2 and strain 13 animals. Strain 13 antistrain 13 anti-BPO-BGG (a strain 13 BPO-BGG) suppressed the in vitro BPO-BGG response of cells from immunized strain 13 animals but did not inhibit the response of cells from immune strain 2 animals. Conversely, the corresponding antiserum raised in a strain 2 combination (a strain 2 BPO-BGG) only inhibited the in vitro BPO-BGG response of strain 2 cells. Furthermore, the inhibitory activity of the antisera could only be absorbed by immune cells from the syngeneic strain. The activity of the a strain 13 BPO-BGG serum was highly specific; the inhibitory activity could only be absorbed by BPO-BGG-sensitive strain 13 cells. The inhibitory activity of the anti-idiotypic sera was predominantly associated with the 19S fraction. The data suggest that immune cells and in particular T lymphocytes from strain 2 and strain 13 guinea pigs possess strain-specific recognition structures from BPO-BGG with the same idiotypes as the corresponding strain-specific immunoglobulins. Furthermore, the production of such inhibitory anti-idiotypic sera was restricted to syngeneic combinations, which suggests a potential role of autoanti-idiotypic antibodies in the regulation of the immune response. The anti-idiotypic antisera used here are apparently directed against gene products not associated with the strain 2 or strain 13 major histocompatibility complex.

DETERMINANT SELECTION: A MACROPHAGE-MEDIATED IMMUNE RESPONSE GENE FUNCTION

1978 ◽  
pp. 405-415 ◽  
Author(s):  
Alan S. Rosenthal ◽  
Lanny J. Rosenwasser ◽  
Marcello A. Barcinski
Keyword(s):  
Immune Response ◽  
Gene Function ◽  
Immune Response Gene ◽  
Response Gene

scholarly journals Antigen-presenting cells from nonresponder strain 2 guinea pigs are fully competent to present bovine insulin B chain to responder strain 13 T cells. Evidence against a determinant selection model and in favor of a clonal deletion model of immune response gene function.

1983 ◽  
Vol 157 (4) ◽  
pp. 1287-1299 ◽  
Author(s):  
G A Dos Reis ◽  
E M Shevach
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Gene Function ◽  
Guinea Pigs ◽  
Bovine Insulin ◽  
Immune Response Gene ◽  
Cell Repertoire ◽  
Clonal Deletion ◽  
Response Gene ◽  
Selection Hypothesis

To test directly the determinant selection hypothesis of immune response gene function, we primed strain 13 T lymphocytes in vitro with allogeneic bovine insulin pulsed strain 2 macrophages. Strain 2 macrophages were found to be fully competent to present bovine insulin B chain to strain 13 T cells despite the fact that strain 2 guinea pigs are normally totally unresponsive to this antigen. These results are incompatible with a strict interpretation of the determinant selection hypothesis, which would have predicted that strain 2 macrophages would have been restricted to the presentation of A chain loop determinants. In addition, a comparison of the reactivity profiles of self-Ia- and allo-Ia-restricted strain 13 T cells to a series of synthetic B chain peptide fragments revealed that the allo-Ia-restricted populations could be activated by autologous guinea pig insulin. Taken together, these observations strongly suggest that the clonal deletion of self-reactive cells is likely to be I region restricted and that nonresponsiveness to any protein antigen may result from a restriction in the T cell repertoire that is generated during ontogeny by a clonal deletion mechanism of tolerance to self.

Thymic immune response gene function in radiation chimeras reconstituted with purified hemopoietic stem cells

1987 ◽  
Vol 17 (4) ◽  
pp. 471-475 ◽  
Author(s):  
W. Martin Kast ◽  
Arie C. Voordouw ◽  
Tine Leupers ◽  
Jan W. M. Visser ◽  
Cornelis J. M. Melief
Keyword(s):  
Stem Cells ◽  
Immune Response ◽  
Gene Function ◽  
Immune Response Gene ◽  
Hemopoietic Stem Cells ◽  
Response Gene ◽  
Radiation Chimeras
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