This chapter lays out the basic themes of the book and examines the commercial and strategic interests of U.S. and China in Latin America. China has become the largest trading partner for more than half of the Latin American countries, while the U.S. has sought to be the preeminent power in Latin America and the Caribbean since 1823 and the announcement of Monroe Doctrine. China does not pose a direct military threat to the U.S. or its Latin interests, but it does represent serious competition in the economic and diplomatic arenas. In the past decade, a clear East-West split has developed among the Latin American states. Venezuela, Brazil, and Argentina became more nationalistic and anti-U.S., while Chile, Columbia, and Peru have tended to be more market-oriented and comfortable working with U.S. power. The U.S. currently benefits from disarray on the Left in Argentina, Brazil, and Venezuela. Newly developed institutions, e.g., UNASUR, the New Development Bank, and TPP, may also change the U.S.’s and China’s influence in the region.