scholarly journals Translation in the making: how older people engaged in a randomised controlled trial on lifestyle changes apply medical knowledge in their everyday lives

Author(s):  
Astrid P. Jespersen ◽  
Aske Juul Lassen ◽  
Thorvald Winsløw Schjeldal

AbstractA recurring discussion in recent health studies relates to knowledge translation (KT), which deals with the questions of how to ensure and measure the uptake of knowledge from one medical situation to another and of how to move the right form of knowledge from one situation to another. Recently, however, this way of understanding KT has received criticism for presenting too basic an understanding of knowledge and not fully grasping the potential of the term translation. Based on qualitative material from a randomised controlled trial (RCT) and a follow-up study, this article takes the current discussion of KT one step further, focussing on how KT happens among healthy citizens participating in a lifestyle intervention. The overall argument is that even current critical understandings of KT often ignore the fact that the translation of medical knowledge does not stop at the clinical encounter but extends into the everyday health practices of the population. A more nuanced understanding of how and in which forms medical knowledge is adopted by people in their everyday health practices will give new insights into the complex mechanisms of KT and the encounter between medical knowledge and practice and everyday life. Hence, this article discuss how knowledge from a clinical trial—focussing on muscular training and increased protein intake—is translated into meaningful health practices. The article concludes the following points: First, constant, and often precarious, work is required to maintain the content of ‘medical knowledge’ in a complex social order. Second, focussing on translation work in everyday life emphasises that KT is an open-ended process, wherein the medical object of knowledge is contested and renegotiated and needs alliances with other objects of knowledge in order to remain relevant. Last, from an everyday life perspective, medical knowledge is just one rationale making up the fabric of people’s health practices; other rationales, such as time, feasibility, logistics and social relations, are just as relevant in determining how and why people pursue healthy living or comply with a medical regimen. CALM trial registration ClinicalTrials.gov NCT02034760. Registered on 10 January 2014; ClinicalTrials.gov NCT02115698. Registered on 14 April 2014; Danish regional committee of the Capital Region H-4-2013-070. Registered on 4 July 2013; Danish Data Protection Agency 2012-58-0004–BBH-2015-001 I-Suite 03432. Registered on 9 January 2015.

2021 ◽  
Author(s):  
Jonathan Wiles ◽  
Melanie Rees-Roberts ◽  
Jamie O’Driscoll ◽  
Timothy Doulton ◽  
Douglas McInnes ◽  
...  

Abstract Background: Hypertension (HTN) affects approximately 25% of the UK population and is a leading cause of mortality. Associated annual health care costs run into billions. National treatment guidance includes initial lifestyle advice, followed by anti-hypertensive medication if blood pressure (BP) remains high. However, adoption and adherence to recommended exercise guidelines, dietary advice and anti-hypertensive medication is poor. Four short bouts of isometric exercise (IE) performed 3 days per week (d/wk) at home elicits clinically significant reductions in BP in those with normal to high-normal BP. This study will determine the feasibility of delivering personalised IE to patients with Stage 1 hypertension for whom lifestyle changes would be recommended before medication within NHS primary care.Methods: This is a randomised controlled feasibility study. Participants 18+ years, with Stage 1 hypertension, not on anti-hypertensive medication and without significant medical contraindications. Trial arms will be standard lifestyle advice (control) or isometric wall squat exercise and standard lifestyle advice. Primary outcomes include success of intervention delivery and change in BP. Secondary outcomes include accuracy of protocol delivery, execution of and adherence to protocol, recruitment rate, attrition, perception of intervention viability, cost, participant experience, and accuracy of home BP. The study will last 18 months. Sample size of 100 participants (50 per arm) allows for 20% attrition and 6.5% incomplete data, based upon 74 (37 each arm) participants (two-sided 95% confidence interval, width of 1.33 and standard deviation of 4) completing 4 weeks. Ethical approval IRAS ID: 274676.Discussion: Before the efficacy of this novel intervention to treat Stage 1 hypertension can be investigated in any large randomised controlled trial, it is necessary to ascertain if it can be delivered and carried out in a NHS primary care setting. Findings could support IE viability as a prophylactic / alternative treatment option.Trial Registration: International Standard Randomised Controlled Trial Number (ISRCTN) 13472393 registered 18 August 2020. http://www.isrctn.com/ISRCTN13472393


BMJ Open ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. e024269 ◽  
Author(s):  
Robyn Gallagher ◽  
Clara Chow ◽  
Helen Parker ◽  
Lis Neubeck ◽  
David Celermajer ◽  
...  

IntroductionRecurrence of cardiac events is common after a first event, leading to hospitalisations and increased health burden. Patients have difficulties achieving the lifestyle changes required for secondary prevention and access to secondary prevention programs is limited. This study aims to evaluate the impact of a game-based mobile app, MyHeartMate, which is designed to motivate engagement in secondary prevention behaviours for cardiovascular risk factors.Methods and analysisThe MyHeartMate study is a randomised controlled trial with 6-month follow-up and blinded assessment of the primary outcome. Participants (n=394) with coronary heart disease will be recruited from hospitals in metropolitan Sydney and randomly allocated to standard care or the MyHeartMate app intervention. The intervention group will receive the app, which uses game techniques to promote engagement and lifestyle behaviour change for secondary prevention. The primary outcome is difference between the groups in physical activity (metabolic equivalent of task minutes/week) at 6 months. Secondary outcomes include change in low-density lipoprotein cholesterol, systolic blood pressure, medication adherence, body mass index, waist circumference, mood and dietary changes at 6 months. Data on app engagement, and patient perspectives of usability and acceptability, will also be analysed.Ethics and disseminationThe study has received ethics approval from Northern Sydney Local Health District Human Research Ethics Committee. The study findings will be disseminated via peer-reviewed publications and presentation at international scientific meetings/conferences.Trial registration numberACTRN12617000869370; Pre-results.



Gut ◽  
2014 ◽  
Vol 64 (8) ◽  
pp. 1268-1276 ◽  
Author(s):  
Paula Berstad ◽  
Magnus Løberg ◽  
Inger Kristin Larsen ◽  
Mette Kalager ◽  
Øyvind Holme ◽  
...  

2012 ◽  
Author(s):  
Sarah Clement ◽  
Adrienne van Nieuwenhuizen ◽  
Aliya Kassam ◽  
Ian Norman ◽  
Clare Flach ◽  
...  

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