Adsorption dynamics of bifunctional molecules: Allyl methyl ether on Si(001)

SummaryEnovid (5 mg norethynodrel and 0.075 mg ethynylestradiol-3-methyl ether) therapy in young normal human subjects causes an increase in plasma fibrinogen of 32.4% (P >C 0.001). Consideration of this effect together with other effects of Enovid on the activity of specific blood coagulatory factors suggests that the steroids are exerting their effect at a specific site of the blood coagulation and/or fibrinolytic system. The broad spectrum of changes which are induced by the steroids may be attributed to a combination of a chain reaction and feed-back control.

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PHOTACs Enable Optical Control of Protein Degradation

10.26434/chemrxiv.8206688 ◽

2019 ◽

Cited By ~ 2

Author(s):

Martin Reynders ◽

Bryan Matsuura ◽

Marleen Bérouti ◽

Daniele Simoneschi ◽

Antonio Marzio ◽

...

Keyword(s):

Protein Degradation ◽

E3 Ligase ◽

Optical Control ◽

Cellular Proteins ◽

Bifunctional Molecules ◽

Protein Levels ◽

Lead Compounds ◽

Subsequent Degradation ◽

Temporal And Spatial ◽

Precision Therapeutics

PROTACs (proteolysis targeting chimeras) are bifunctional molecules that tag proteins for ubiquitylation by an E3 ligase complex and subsequent degradation by the proteasome. They have emerged as powerful tools to control the levels of specific cellular proteins and are on the verge of being clinically used. We now introduce photoswitchable PROTACs that can be activated with the temporal and spatial precision that light provides. These trifunctional molecules, which we named PHOTACs, consist of a ligand for an E3 ligase, a photoswitch, and a ligand for a protein of interest. We demonstrate this concept by using PHOTACs that target either BET family proteins (BRD2,3,4) or FKBP12. Our lead compounds display little or no activity in the dark but can be reversibly activated to varying degrees with different wavelengths of light. Our modular and generalizable approach provides a method for the optical control of protein levels with photopharmacology and could lead to new types of precision therapeutics that avoid undesired systemic toxicity.

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Substance Overview for Propylene glycol 1-methyl ether-2-acetate

The MAK-Collection for Occupational Health and Safety ◽

10.1002/3527600418.mbe10865 ◽

2014 ◽

pp. 1-1

Keyword(s):

Propylene Glycol ◽

Methyl Ether

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Excess volumes and refractive indices in the benzene-tert-amyl methyl ether and cyclohexane-tert-amyl methyl ether systems at 298.15 K

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19872839 ◽

1987 ◽

Vol 52 (12) ◽

pp. 2839-2843 ◽

Cited By ~ 18

Author(s):

Jan Linek

Keyword(s):

Methyl Ether ◽

Excess Molar Volumes ◽

Excess Volumes ◽

Refractive Indices ◽

Molar Volumes ◽

Vibrating Tube Densimeter ◽

Ether System

Excess molar volumes in the benzene-tert-amyl methyl ether and cyclohexane-tert-amyl methyl ether systems were measured by a vibrating-tube densimeter at 298.15 K and compared with the data for the methanol-tert-amyl methyl ether system determined previously. Besides, the refractive indices in both the systems were measured at the same temperature.

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Crystal Structures of Two New Cyclosporin Clathrates

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc20001950 ◽

2000 ◽

Vol 65 (12) ◽

pp. 1950-1958 ◽

Cited By ~ 2

Author(s):

Michal Hušák ◽

Bohumil Kratochvíl ◽

Ivana Císařová ◽

Alexandr Jegorov

Keyword(s):

Crystal Structures ◽

Methyl Ether ◽

Van Der Waals ◽

Van Der Waals Interactions ◽

Solvent Molecules ◽

Butyl Methyl Ether

Two isomorphous clathrates formed by dihydrocyclosporin A or cyclosporin V with tert-butyl methyl ether are reported and compared with the structures of related P21-symmetry cyclosporin clathrates. The cyclosporin molecules in both structures are associated via van der Waals interactions forming cavities occupied by solvent molecules (cyclosporin : tert-butyl methyl ether is 1 : 2).

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