scholarly journals Potential compounds phenolic group sawo leaves (Manilkara zapota) as an α-amylase inhibitor in type 2 diabetes mellitus by in silico

2021 ◽  
Author(s):  
Siti Imroatul Maslikah ◽  
Rif'atul Chusnul Khuluq ◽  
Ilfia Kholifaturrohmah ◽  
Lintang Miftahul Rizki ◽  
Atikah Amalia
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
In Silico ◽  
Manilkara Zapota ◽  
Amylase Inhibitor ◽  
Phenolic Group

scholarly journals In silico network pharmacology and in vivo analysis of berberine-related mechanisms against type 2 diabetes mellitus and its complications

2021 ◽  
pp. 114180
Author(s):  
Sha Di ◽  
Lin Han ◽  
Xuedong An ◽  
Ran Kong ◽  
Zezheng Gao ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
In Silico ◽  
Network Pharmacology ◽  
In Vivo Analysis

scholarly journals A Comparative Study of Gallic Acid, Ellagic Acid, Urolithin A, and Urolithin B with NF-κB Protein as Anti Type 2 Diabetes Mellitus by In Silico

JSMARTech ◽  
2020 ◽  
Vol 1 (2) ◽  
pp. 31-35
Author(s):  
Maulida Hikmaranti ◽  
◽  
Ajeng M. Astiyani ◽  
Khairul M. Hasanah ◽  
Nuril M. Maghfiroh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Comparative Study ◽  
Gallic Acid ◽  
Ellagic Acid ◽  
In Silico ◽  
Urolithin A ◽  
Urolithin B

scholarly journals IN SILICO ANALYSIS OF ACTIVE CONSTITUENTS OF SILYMARIN AS ΑLPHA-GLUCOSIDASE ENZYME INHIBITORS IN TYPE 2 DIABETES MELLITUS

2019 ◽  
pp. 225-229 ◽  
Author(s):  
AHMAD ZONOUBI ◽  
PRASHANTHA CN ◽  
D VISAGA PERUMAL ◽  
ZAHRA MAFIBANIASADI
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
In Silico ◽  
Enzyme Inhibitors ◽  
In Silico Analysis ◽  
Active Constituents ◽  
Alpha Glucosidase ◽  
Silico Analysis

Objective: Type 2 diabetes mellitus (T2DM) is an acute metabolic disorder, in which the vogue is increasing persistently globally. The maltase-glucoamylase/alpha-glucosidase inhibitor is an oral antidiabetic drug collectively, which is utilizing for regulating carbohydrates that ordinarily transformed into simple sugars and absorbed by the intestine. Researchers need to constantly explore alternative therapeutic strategies for the clinical management of DM due to the increased adverse event caused by conservative antidiabetic agents. The present study proposes a substitute drug to examine the seven bioactive phytocomponents of Silybum marianum (milk thistle) that can regulate the hyperglycemia by downregulating alpha-glucosidase and its activity. Methods: Different integrated web-based in silico tools and techniques were used to model the enzyme (receptor) as well as to determine the druggability of different active constituents of silymarin and their pharmacokinetics were predicted. Further, the active site of the enzyme was predicted followed by molecular docking method. Results: The results show silychristin A and silydianin having less carcinogenicity and strong interaction to the target protein (alpha-glucosidase) compare to the reference drugs (acarbose and miglitol) and these two molecules can be used for the best drug molecules in T2DM. Conclusion: In the proposed study, the in silico analysis helps researchers to utilize these compounds for clinical applications. The conclusion also suggests that synthetically and semi-synthetically, nucleus and peripheral modifications, either in the form of skeletal rearrangements or partial degradations as well as functional group addition and replacement of the active molecules present in silymarin giving access to new structural motifs, which can be used in future as a lead compounds for antagonising the alpha-glucosidase in the treatment of diabetes mellitus.

In vitro and in silico inhibition properties of fucoidan against α-amylase and α-D-glucosidase with relevance to type 2 diabetes mellitus

2019 ◽  
Vol 209 ◽  
pp. 350-355 ◽  
Author(s):  
Lakshmana Senthil S. ◽  
Chandrasekaran Raghu ◽  
Arjun H.A. ◽  
Anantharaman P.
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
In Silico

scholarly journals Green synthesis and in silico characterization of 4-Hydroxy-3- methoxybenzaldehyde Schiff bases for insulysin inhibition – a potential lead for type 2 diabetes mellitus

2020 ◽  
Author(s):  
Chigurupati Sridevi ◽  
Palanimuthu Vasanth Raj ◽  
Kanagaraj Suganya ◽  
Sundaravadivelu Sumathi ◽  
Varadharajula Venkata Ramaiah
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Green Synthesis ◽  
Schiff Bases ◽  
In Silico ◽  
In Silico Characterization
Sign in / Sign up

Export Citation Format

Share Document