In vivo effects of interleukin-10 on human cytochrome P450 activity

2000 ◽  
Vol 67 (1) ◽  
pp. 32-43 ◽  
Author(s):  
J Gorski
Keyword(s):  
Cytochrome P450 ◽  
Interleukin 10 ◽  
Cytochrome P450 Activity ◽  
Human Cytochrome ◽  
In Vivo Effects ◽  
P450 Activity

Effect of sinomenine on human cytochrome P450 activity

2007 ◽  
Vol 379 (1-2) ◽  
pp. 113-118 ◽  
Author(s):  
Yong-Mei Yao ◽  
Wei Cao ◽  
Ya-Jie Cao ◽  
Ze-Neng Cheng ◽  
Dong-Sheng Ou-Yang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 Activity ◽  
Human Cytochrome ◽  
P450 Activity

Interspecies differences in the cytochrome P450 activity of hepatocytes exposed to PLGA and silica nanoparticles: an in vitro and in vivo investigation

Nanoscale ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 5171-5181 ◽  
Author(s):  
Raphaël Cornu ◽  
Nathalie Rougier ◽  
Yann Pellequer ◽  
Alf Lamprecht ◽  
Paul Hamon ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Silica Nanoparticles ◽  
Interspecies Differences ◽  
Hepatic Cells ◽  
Cytochrome P450 Activity ◽  
Set Up ◽  
P450 Activity

This study emphasizes the interest to set up relevant in vitro models using human hepatic cells to evaluate the hepatotoxicity of nanomedicines.

scholarly journals Rational engineering of photosynthetic electron flux enhances light-powered cytochrome P450 activity

2018 ◽  
Vol 3 (1) ◽  
Author(s):  
Adokiye Berepiki ◽  
John R Gittins ◽  
C Mark Moore ◽  
Thomas S Bibby
Keyword(s):  
Cytochrome P450 ◽  
Electron Flow ◽  
Nicotinamide Adenine Dinucleotide Phosphate ◽  
Experimental System ◽  
Type I ◽  
Photosynthetic Electron Flow ◽  
Cytochrome P450 Activity ◽  
The Impact ◽  
P450 Activity

AbstractIn this study, we exploited a modified photosynthetic electron transfer chain (PET) in the model cyanobacterium Synechococcus PCC 7002, where electrons derived from water-splitting are used to power reactions catalyzed by a heterologous cytochrome P450 (CYP1A1). A simple in vivo fluorescent assay for CYP1A1 activity was employed to determine the impact of rationally engineering of photosynthetic electron flow. This showed that knocking out a subunit of the type I NADH dehydrogenase complex (NDH-1), suggested to be involved in cyclic photosynthetic electron flow (ΔndhD2), can double the activity of CYP1A1, with a concomitant increase in the flux of electrons from photosynthesis. This also resulted in an increase in cellular adenosine triphosphate (ATP) and the ATP/nicotinamide adenine dinucleotide phosphate (NADPH) ratio, suggesting that expression of a heterologous electron sink in photosynthetic organisms can be used to modify the bioenergetic landscape of the cell. We therefore demonstrate that CYP1A1 is limited by electron supply and that photosynthesis can be re-engineered to increase heterologous P450 activity for the production of high-value bioproducts. The increase in cellular ATP achieved could be harnessed to support metabolically demanding heterologous processes. Furthermore, this experimental system could provide valuable insights into the mechanisms of photosynthesis.

scholarly journals Effects of Repeated Green Tea Catechin Administration on Human Cytochrome P450 Activity

2006 ◽  
Vol 15 (12) ◽  
pp. 2473-2476 ◽  
Author(s):  
H-H. Sherry Chow ◽  
Iman A. Hakim ◽  
Donna R. Vining ◽  
James A. Crowell ◽  
Catherine A. Cordova ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Green Tea ◽  
Cytochrome P450 Activity ◽  
Human Cytochrome ◽  
Green Tea Catechin ◽  
P450 Activity

scholarly journals A Comparison of the In Vitro Inhibitory Effects of Thelephoric Acid and SKF-525A on Human Cytochrome P450 Activity

2014 ◽  
Vol 22 (2) ◽  
pp. 155-160 ◽  
Author(s):  
Min Song ◽  
HyunHee Do ◽  
Oh Kwang Kwon ◽  
Eun-Ju Yang ◽  
Jong-Sup Bae ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Inhibitory Effects ◽  
Cytochrome P450 Activity ◽  
Human Cytochrome ◽  
P450 Activity
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