Patch testing discordance alert: False-negative findings with rubber additives and fragrances

2001 ◽  
Vol 45 (2) ◽  
pp. 313-314 ◽  
Author(s):  
Elizabeth F. Sherertz ◽  
Anthony F. Fransway ◽  
Donald V. Belsito ◽  
Vincent A. DeLeo ◽  
Joseph F. Fowler ◽  
...  
Keyword(s):  
Patch Testing ◽  
False Negative ◽  
Negative Findings

scholarly journals Impact of repeated nasal sampling on detection and quantification of SARS-CoV-2

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Joshua M. Levy ◽  
Jennifer K. Frediani ◽  
Erika A. Tyburski ◽  
Anna Wood ◽  
Janet Figueroa ◽  
...  
Keyword(s):  
Test Performance ◽  
Perceived Risk ◽  
False Negative ◽  
Sample Collection ◽  
Diagnostic Assays ◽  
Negative Findings ◽  
High Concordance ◽  
Repeated Sample ◽  
Multiple Samples ◽  
The Impact

AbstractThe impact of repeated sample collection on COVID-19 test performance is unknown. The FDA and CDC currently recommend the primary collection of diagnostic samples to minimize the perceived risk of false-negative findings. We therefore evaluated the association between repeated sample collection and test performance among 325 symptomatic patients undergoing COVID-19 testing in Atlanta, GA. High concordance was found between consecutively collected mid-turbinate samples with both molecular (n = 74, 100% concordance) and antigen-based (n = 147, 97% concordance, kappa = 0.95, CI = 0.88–1.00) diagnostic assays. Repeated sample collection does not decrease COVID-19 test performance, demonstrating that multiple samples can be collected for assay validation and clinical diagnosis.

False-positive and false-negative findings on chorionic villus sampling

1987 ◽  
Vol 7 (9) ◽  
pp. 671-672 ◽  
Author(s):  
G. Simoni ◽  
M. Fraccaro ◽  
G. Gimelli ◽  
F. Maggi ◽  
F. Dagna Bricarelli
Keyword(s):  
False Positive ◽  
False Negative ◽  
Chorionic Villus ◽  
Chorionic Villus Sampling ◽  
Negative Findings

scholarly journals Inappropriate Nasopharyngeal Sampling for SARS-CoV-2 Detection Is a Relevant Cause of False-Negative Reports

2020 ◽  
Vol 163 (3) ◽  
pp. 459-461 ◽  
Author(s):  
Antonio Piras ◽  
Davide Rizzo ◽  
Sergio Uzzau ◽  
Giacomo De Riu ◽  
Salvatore Rubino ◽  
...  
Keyword(s):  
Nasal Obstruction ◽  
Negative Impact ◽  
Present Report ◽  
False Negative ◽  
Nasopharyngeal Swab ◽  
Rt Pcr ◽  
Radiologic Findings ◽  
Negative Findings ◽  
Current Outbreak ◽  
Polymerase Chain

Reverse transcriptase polymerase chain reaction (RT-PCR) detection of SARS-CoV-2 mRNA on nasopharyngeal swab is the standard for diagnosing active COVID-19 disease in asymptomatic cases and in symptomatic patients without the typical radiologic findings. For the present COVID-19 outbreak in Italy, we describe 4 symptomatic patients with negative RT-PCR results at the first nasopharyngeal swab, which became positive when collected a few hours later by an otolaryngologist. All the patients showed nasal obstruction. The present report suggests that inadequate nasopharyngeal sampling performed by untrained operators in the presence of nasal obstruction can be a relevant case of false-negative findings at RT-PCR, with a clear negative impact on the efforts to contain the current outbreak.

The sentinel lymph node biopsy technique in papillary thyroid carcinoma: The issue of false-negative findings

2020 ◽  
Vol 46 (6) ◽  
pp. 967-975 ◽  
Author(s):  
Ludovico M. Garau ◽  
Domenico Rubello ◽  
Simona Muccioli ◽  
Giuseppe Boni ◽  
Duccio Volterrani ◽  
...  
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Thyroid Carcinoma ◽  
False Negative ◽  
Lymph Node Biopsy ◽  
Papillary Thyroid ◽  
Node Biopsy ◽  
Negative Findings

scholarly journals A novel framework for evaluating the performance of codon usage bias metrics

2018 ◽  
Vol 15 (138) ◽  
pp. 20170667 ◽  
Author(s):  
Sophia S. Liu ◽  
Adam J. Hockenberry ◽  
Michael C. Jewett ◽  
Luís A. N. Amaral
Keyword(s):  
Codon Usage ◽  
Dna Sequences ◽  
Codon Usage Bias ◽  
False Negative ◽  
Gc Content ◽  
Sequence Length ◽  
Protein Coding ◽  
Cellular Processes ◽  
Negative Findings ◽  
Measured Effect

The unequal utilization of synonymous codons affects numerous cellular processes including translation rates, protein folding and mRNA degradation. In order to understand the biological impact of variable codon usage bias (CUB) between genes and genomes, it is crucial to be able to accurately measure CUB for a given sequence. A large number of metrics have been developed for this purpose, but there is currently no way of systematically testing the accuracy of individual metrics or knowing whether metrics provide consistent results. This lack of standardization can result in false-positive and false-negative findings if underpowered or inaccurate metrics are applied as tools for discovery. Here, we show that the choice of CUB metric impacts both the significance and measured effect sizes in numerous empirical datasets, raising questions about the generality of findings in published research. To bring about standardization, we developed a novel method to create synthetic protein-coding DNA sequences according to different models of codon usage. We use these benchmark sequences to identify the most accurate and robust metrics with regard to sequence length, GC content and amino acid heterogeneity. Finally, we show how our benchmark can aid the development of new metrics by providing feedback on its performance compared to the state of the art.

Screening US for Blunt Abdominal Trauma: Objective Predictors of False-Negative Findings and Missed Injuries

Radiology ◽  
2003 ◽  
Vol 229 (3) ◽  
pp. 766-774 ◽  
Author(s):  
Claude B. Sirlin ◽  
Michèle A. Brown ◽  
Reena Deutsch ◽  
Olga A. Andrade-Barreto ◽  
Dale A. Fortlage ◽  
...  
Keyword(s):  
Abdominal Trauma ◽  
Blunt Abdominal Trauma ◽  
False Negative ◽  
Missed Injuries ◽  
Negative Findings

scholarly journals False-negative findings in skin cancer and melanoma screening

1995 ◽  
Vol 33 (1) ◽  
pp. 59-63 ◽  
Author(s):  
Frans H.J Rampen ◽  
Idy J.A.M.G Casparie-van Velsen ◽  
Barbara E.W.L van Huystee ◽  
Lambertus A.L.M Kiemeney ◽  
Leo J Schouten
Keyword(s):  
Skin Cancer ◽  
False Negative ◽  
Negative Findings ◽  
Melanoma Screening

Rate of false-negative findings in sentinel lymph node biopsy in patients with head and neck malignant melanoma.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e17566-e17566
Author(s):  
Roman Rahimi-Nedjat ◽  
Keyvan Sagheb ◽  
Maike Hormes ◽  
Andrea Tuettenberg ◽  
Bilal Al-Nawas ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Malignant Melanoma ◽  
Cervical Lymph Node ◽  
False Negative ◽  
Lymph Node Biopsy ◽  
Tumor Thickness ◽  
Node Biopsy ◽  
Negative Findings ◽  
One Year

e17566 Background: Sentinel Lymph Node Biopsy (SLNB) is the standard procedure for malignant melanoma with a thicknes above 1mm. However, the benefits of this procedure have recently been questioned because of a high number of false negative findings. The aim of our study was to investigate the number of early recurrence in patients with negative SLNB. Methods: All patients with malignant melanoma of the head and neck region who underwent SLNB between 2010 and 2016 in our department were included and data reviewed retrospectively. Recurrence in the same cervical lymph node region of the previously extirpated sentinel lymph node (SLN) within one year was defined as primary false-negative. Results: Allover 101 patients were investigated (mean age 62.48 years (±17.66; 73.3% ♂, 26.7% ♀). Most frequent location of the primary melanoma were the cheeks and ears (each 18.8%), followed by the hair bearing region (13.9%). Superficial Spreading Melanoma and Nodular Melanoma were the most frequently seen subtypes (each 23.8%), followed by Lentigo maligna Melanoma (19.8%). Median thickness of all patients was 2.5mm (min: 0.15 – max: 10.0 mm). In average 3 SLN were removed during operation (min: 1 – max 16). In 79.2% of the cases the SLN was negative. 13% showed one metastasis, 5.2% showed two and 1.6% three metastases. Positive findings in the SLN were significantly correlated with T-classification. Ulceration and tumor thickness showed significant tendencies in Χ2-Test and Mann-Whitney-Test. Out of the patients with negative SLN 13.1% had at least one metastasis in a cervical lymph node of the same region within one year. Mean duration until recurrence was 6.5 months. 75.0% of the metastases in our study were diagnosed within this period. 62.5% of the patients with secondary positive SLN had a tumor of intermediate thickness (between 1mm and 4mm). Conclusions: With 13.1 % secondary positive SLN this study shows that SLNB has a high rate of false-negative findings. However, SLNB has lower complication rates compared to traditional lymph node extirpation. This study shows that patients with negative SLN especially with intermediate tumor thickness should be controlled by ultrasound or computer tomography in short intervals.

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