Glucose tolerance of sheep as related to post-mortem muscle characteristics

1970 ◽  
Vol 21 (6) ◽  
pp. 939 ◽  
Author(s):  
WR Shorthose
Keyword(s):  
Glucose Tolerance ◽  
Plasma Glucose ◽  
Muscle Glycogen ◽  
Glucose Concentration ◽  
Tolerance Test ◽  
Post Mortem ◽  
Muscle Properties ◽  
Rate Of Decline ◽  
Sampling Procedures ◽  
Muscle Glycogen Concentration

The glucose tolerance, expressed as T 1/2, of sheep unaccustomed to blood sampling procedures was negatively correlated with the muscle glycogen concentration of the M. semitendinosus (ST) immediately after death and the extent of glycolysis. T 1/2 was positively correlated with the pH of the ST 24 hr after death. It was suggested that the rate of decline of plasma glucose concentration in a tolerance test was influenced by the animal's response to venipuncture and handling during the test. The extent of the animal's response to this stress was considered to be related to the animal's response to pre-slaughter stress and to account for the correlations between T 1/2 and post-mortem muscle properties.

Evaluation of the relationship between the one-hour plasma glucose concentration and beta-cell functions and cardiometabolic parameters during oral glucose tolerance test in obese children and adolescents

2020 ◽  
Vol 33 (6) ◽  
pp. 767-775
Author(s):  
Eda Mengen ◽  
Seyit Ahmet Uçaktürk
Keyword(s):  
Glucose Tolerance ◽  
Beta Cell ◽  
Plasma Glucose ◽  
Glucose Concentration ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Plasma Glucose Concentration ◽  
Oral Glucose ◽  
Cell Functions ◽  
The Relationship

AbstractBackgroundIn this study, we aimed to evaluate the relationship between the 1-h plasma glucose (PG) level in the oral glucose tolerance test (OGTT) and conventional glycemic parameters, indices evaluating beta-cell functions, and cardiometabolic risk factors.MethodsThe records of 532 obese patients who were followed up in the Pediatric Endocrinology Polyclinic and who underwent standard OGTT were evaluated retrospectively. All patients were divided into two groups according to OGTT data as the 1-h plasma glucose concentration <155 mg/dL (n=329) and ≥155 mg/dL (n=203). Patients with normal glucose tolerance (NGT) were divided into two groups according to the 1-h PG level, as 218 patients with NGT 1 h-low (<155 mg/dL) and 53 patients with high NGT 1 h-high (≥155 mg/dL).ResultsThere was a statistically significant difference between the lipid profiles of individuals with NGT 1 h-low (<155 mg/dL) and individuals with NGT 1 h-high (≥155 mg/dL) (p<0.001). Total cholesterol, LDL cholesterol, and triglyceride levels were higher, while HDL cholesterol levels were lower in individuals with NGT 1 h-high (≥155 mg/dL). The indices evaluating beta-cell functions were significantly higher in individuals with NGT 1 h-low (<155 mg/dL).ConclusionAs a result, a plasma glucose concentration above or equal to 155 mg/dL at 1 h during an OGTT is associated with a worse clinical phenotype characterized by changes in insulin sensitivity and β-cell function. Therefore, this threshold value can predict the progression of prediabetes in obese young people with NGT.

Glucose tolerance and insulin action in healthy centenarians

1996 ◽  
Vol 270 (5) ◽  
pp. E890-E894 ◽  
Author(s):  
G. Paolisso ◽  
A. Gambardella ◽  
S. Ammendola ◽  
A. D'Amore ◽  
V. Balbi ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Plasma Glucose ◽  
Insulin Action ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Fat Free Mass ◽  
Whole Body ◽  
Glucose Disposal ◽  
Oral Glucose ◽  
Aged Subjects

Advancing age has been found to be associated with a decline in insulin action. Nevertheless, no study has been conducted in healthy centenarians. Our study investigates glucose tolerance and insulin action in centenarians. Fifty-two subjects were enrolled. The subjects were divided in three groups as follows: 1) adults (< 50 yr; n = 20);2) aged subjects (> 75 yr; n = 22); and 3) centenarians (> 100 yr; n = 14). Body composition was studied by bioimpedance analysis. In all subjects, an oral glucose tolerance test and euglycemic glucose clamp were performed. Centenarians have a lower fat-free mass (FFM) than aged subjects and adults, whereas fasting plasma glucose, triglycerides, free fatty acids, urea, and creatinine were not different in the groups studies. Centenarians had a 2-h plasma glucose concentration (6.0 +/- 0.2 mmol/l) that was lower than that in aged subjects (6.6 +/- 0.5 mmol/l, P < 0.05) but not different from adults [6.4 +/- 0.4 mmol/l, P = not significant (NS)]. During the clamp, plasma glucose and insulin concentrations were similar in the three groups. In these conditions, centenarians had a whole body glucose disposal (34.1 +/- 0.6 mumol.kg FFM-1.min 1) that was greater than that in aged subjects (23.3 +/- 0.5 mumol.kg FFM-1.min-1 P < 0.01) but not different from adults (34.6 +/- 0.5 mumol/kg x min, P = NS). In conclusion, our study demonstrates that centenarians compared with aged subjects had a preserved glucose tolerance and insulin action.

scholarly journals Capillary glucose concentration during oral glucose tolerance test for the diagnosis of gestational diabetes

2020 ◽  
Vol 150 (2) ◽  
pp. 234-240 ◽  
Author(s):  
Ainoha García‐Claver ◽  
Raquel Ramos‐Corral ◽  
Concepción Laviña‐Fañanás ◽  
Isabel Solans‐Blecua ◽  
José Puzo‐Foncillas
Keyword(s):  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Oral Glucose Tolerance Test ◽  
Glucose Concentration ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Capillary Glucose

scholarly journals Influence of Breastfeeding During the Postpartum Oral Glucose Tolerance Test on Plasma Glucose and Insulin

2012 ◽  
Vol 120 (1) ◽  
pp. 136-143 ◽  
Author(s):  
Erica P. Gunderson ◽  
Yvonne Crites ◽  
Vicky Chiang ◽  
David Walton ◽  
Robert A. Azevedo ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Oral Glucose Tolerance Test ◽  
Plasma Glucose ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance

scholarly journals 1-Hour OGTT Plasma Glucose as a Marker of Progressive Deterioration of Insulin Secretion and Action in Pregnant Women

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Alessandra Ghio ◽  
Giuseppe Seghieri ◽  
Cristina Lencioni ◽  
Roberto Anichini ◽  
Alessandra Bertolotto ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Pregnant Women ◽  
Plasma Glucose ◽  
Glucose Concentration ◽  
Insulin Action ◽  
Progressive Increase ◽  
Plasma Glucose Concentration ◽  
Linear Manner

Considering old GDM diagnostic criteria, alterations in insulin secretion and action are present in women with GDM as well as in women with one abnormal value (OAV) during OGTT. Our aim is to assess if changes in insulin action and secretion during pregnancy are related to 1-hour plasma glucose concentration during OGTT. We evaluated 3 h/100 g OGTT in 4,053 pregnant women, dividing our population on the basis of 20 mg/dL increment of plasma glucose concentration at 1 h OGTT generating 5 groups (<120 mg/dL,n=661; 120–139 mg/dL,n=710; 140–159 mg/dL,n=912; 160–179 mg/dL,n=885; and ≥180 mg/dL,n=996). We calculated incremental area under glucose (AUCgluc) and insulin curves (AUCins), indexes of insulin secretion (HOMA-B), and insulin sensitivity (HOMA-R), AUCins/AUCgluc. AUCglucand AUCinsprogressively increased according to 1-hour plasma glucose concentrations (bothP<0.0001for trend). HOMA-B progressively declined (P<0.001), and HOMA-R progressively increased across the five groups. AUCins/AUCglucdecreased in a linear manner across the 5 groups (P<0.001). Analysing the groups with 1-hour value <180 mg/dL, defects in insulin secretion (HOMA-B: −29.7%) and sensitivity (HOMA-R: +15%) indexes were still apparent (allP<0.001). Progressive increase in 1-hour OGTT is associated with deterioration of glucose tolerance and alterations in indexes of insulin action and secretion.

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