Selenium fertilizers for pastures grazed by sheep. 1. Selenium concentrations in whole blood and plasma

1994 ◽  
Vol 45 (4) ◽  
pp. 863 ◽  
Author(s):  
BR Whelan ◽  
DW Peter ◽  
NJ Barrow

Two forms of prilled selenium fertilizer from Mintech N.Z., Na2 SeO4 (Selcote�) and BaSe04 incorporating a slow-release technology, were applied to pasture once at 10 and 20 g Se ha-1 in 1987 at Bakers Hill, Western Australia. The pasture was grazed at 10 sheep ha-1 for 3 years. In the first year, half the sheep were also treated with a selenium intra-ruminal pellet. The Selcote fertilizer produced a rapid rise in pasture selenium concentration, resulting in a similar response in the concentrations of selenium in the whole blood and plasma which reached their maximum values within 7 weeks of commencing grazing. The selenium concentration then declined until, after 15 months, there was insufficient selenium in the pastures to increase the selenium status of sheep. In contrast, the slow-release formulation provided adequate selenium in each of the 3 years with sheep reaching their maximum plasma selenium of 80 8g Se L-1 in the second and third year. At relatively low values for whole blood selenium (< 75 pg Se L-1), supplying an additional selenium source had an additive effect on selenium concentration in the blood, but at higher concentrations (> 350 8g Se L-1) additional sources of selenium only marginally increased the whole blood concentration of selenium. Plasma was a more sensitive indicator of the selenium content of pasture in the short term than whole blood. The results indicate that either Selcote or the BaSe04 fertilizer provides an effective alternative to current strategies for supplying Se to grazing animals.

Gut ◽  
1999 ◽  
Vol 44 (6) ◽  
pp. 886-888 ◽  
Author(s):  
P Deltenre ◽  
A Berson ◽  
P Marcellin ◽  
C Degott ◽  
M Biour ◽  
...  

BACKGROUNDTreatment of ulcerative colitis or Crohn’s disease with sulphasalazine causes several adverse effects, including hepatitis. Sulphasalazine is cleaved by colonic bacteria into 5-aminosalicylic acid and sulphapyridine. Received wisdom was that 5-aminosalicylic acid was topically active, whereas sulphapyridine was absorbed and caused immunoallergic side effects. Mesalazine, a slow release formulation of 5-aminosalicylic acid, was expected to be a safe alternative. However, several cases of acute hepatitis have been reported.CASE REPORTA 65 year old man had increased liver enzymes, anti-nuclear and anti-smooth muscle autoantibodies and IgG levels, and lesions of chronic hepatitis after 21 months of mesalazine treatment. Although liver dysfunction had been identified eight months earlier, simvastatin rather than mesalazine had been withdrawn, without any improvement. In contrast, liver enzyme and IgG levels became normal and autoantibodies disappeared after discontinuation of mesalazine administration.CONCLUSIONContrary to initial expectations, mesalazine can cause most of the sulphasalazine induced adverse effects, and hepatic side effects may be almost as frequent. When liver dysfunction occurs, mesalazine administration should be discontinued to avoid the development of chronic hepatitis and liver fibrosis.


1979 ◽  
Vol 19 (101) ◽  
pp. 689 ◽  
Author(s):  
SK Walker ◽  
GP Hall ◽  
DH Smith ◽  
RW Ponzoni ◽  
GJ Judson

The responses in liveweight, wool weight and survival, to selenium supplementation, were studied in young sheep from weaning to yearling age. The experiment was conducted over three years. In the first year, one sodium selenite supplementation rate was used (total dose 46.5 mg). During the following two years two supplementation rates were administered (total doses 46.5 mg and 93 mg). Mean concentrations of selenium in whole blood in unsupplemented sheep varied from 0.19-0.56 pmol l-l and from 0.20-0.44 pmol l-1 in the two years in which concentrations were measured. Supplementation, which commenced at lamb marking, increased the selenium concentration in sheep at weaning and thereafter. Selenium supplementation improved the break-of-season weight (P < 0.01) and yearling weight (P < 0.01 ) but not weaning weight (0.05 < P < 0.1 ). Hogget fleece weight was improved (P < 0.01 ) and mortality reduced (P < 0.01) by selenium supplementation. There was a treatment x year interaction in mortality rates (P < 0.01 ). There were no significant differences between the two supplementation rates


2005 ◽  
Vol 53 (6) ◽  
pp. 1938-1944 ◽  
Author(s):  
Kenneth D. R. Setchell ◽  
Amnon Brzezinski ◽  
Nadine M. Brown ◽  
Pankaj B. Desai ◽  
Murad Melhem ◽  
...  

1991 ◽  
Vol 36 (12) ◽  
pp. 1735-1740 ◽  
Author(s):  
S. Bondesen ◽  
J. Hegnh�j ◽  
F. Larsen ◽  
S. Honor� Hansen ◽  
C. P. Hansen ◽  
...  

1972 ◽  
Vol 10 (10) ◽  
pp. 40-40

Depronal SA is a slow-release formulation of dextropropoxyphene,1 a synthetic non-narcotic drug with about the same analgesic effect as codeine. The drug is available alone as 65 mg capsules (Doloxene) and also mixed with various other drugs, e.g. as Doloxene Co-65 (with aspirin, phenacetin and caffeine) and as Distalgesic (with paracetamol).


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