scholarly journals Chemically Specific Imaging Through Stimulated Raman Photoexcitation and Ultrasound Detection: Minireview

2012 ◽  
Vol 65 (3) ◽  
pp. 260 ◽  
Author(s):  
Vladislav V. Yakovlev ◽  
Georgi I. Petrov ◽  
Hao F. Zhang ◽  
Gary D. Noojin ◽  
Patrick A. Thomas ◽  
...  
Keyword(s):  
Ultrasound Imaging ◽  
Chemical Compounds ◽  
Clinical Applications ◽  
Scattering Medium ◽  
Deep Tissue ◽  
Spatially Resolved ◽  
Stimulated Raman

A powerful combination of chemically specific Raman excitation and deep tissue ultrasound imaging holds the promise to attain spatially resolved distribution of chemical compounds inside the scattering medium. In this report, an attempt is made to evaluate the recent achievements and possible challenges with an eye on potential clinical applications.

Adaptive Multifocus Beamforming for Contrast-Enhanced-Super-Resolution Ultrasound Imaging in Deep Tissue

2018 ◽  
Vol 65 (12) ◽  
pp. 2255-2263 ◽  
Author(s):  
David Espindola ◽  
Fanglue Lin ◽  
Danai E. Soulioti ◽  
Paul A. Dayton ◽  
Gianmarco F. Pinton
Keyword(s):  
Ultrasound Imaging ◽  
Super Resolution ◽  
Deep Tissue ◽  
Contrast Enhanced

Stimulated Raman scattering signal generation in a scattering medium using self-reconstructing Bessel beams

2020 ◽  
Vol 8 (6) ◽  
pp. 929
Author(s):  
Xueli Chen ◽  
Xinyu Wang ◽  
Lin Wang ◽  
Peng Lin ◽  
Yonghua Zhan ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Stimulated Raman Scattering ◽  
Signal Generation ◽  
Scattering Medium ◽  
Bessel Beams ◽  
Scattering Signal ◽  
Stimulated Raman

Differences in Chemical Component and Anticancer Activity of Green and Ripe Forsythiae Fructus

2017 ◽  
Vol 45 (07) ◽  
pp. 1513-1536 ◽  
Author(s):  
Jiaolin Bao ◽  
Ren-Bo Ding ◽  
Yeer Liang ◽  
Fang Liu ◽  
Kai Wang ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Principal Component ◽  
Chemical Compounds ◽  
Clinical Applications ◽  
Chemical Components ◽  
Aqueous Extracts ◽  
Clear Separation ◽  
Marker Compounds

Forsythiae Fructus, Lianqiao in Chinese, is one of the most fundamental herbs in Traditional Chinese Medicine. Both green Forsythia (GF) and ripe Forsythia (RF) are referred to Forsythiae Fructus in medicinal applications. In most cases, they are used without distinction. In this study, a metabolomics approach was performed to compare componential differences of two Forsythiae Fructus aqueous extracts subtypes. Principal component analysis (PCA) score plots from the UPLC-MS data showed clear separation between the two subtypes, indicating there are significant differences in the chemical components between GF and RF. Meanwhile, the anticancer activity of them was also compared. GF exhibited much stronger antitumor activity than RF against B16-F10 murine melanoma both in vitro and in vivo. 15 chemical compounds were identified as specific markers for distinguishing GF and RF. Among these marker compounds, forsythoside I, forsythoside A, forsythoside E and pinoresinol were demonstrated to be key important active compounds that account for the different anticancer efficacies of GF and RF. Our data suggest that GF and RF should be distinctively used in clinical applications, particularly in the anticancer formulas, in which GF should be preferentially prescribed.

scholarly journals Towards clinical photoacoustic and ultrasound imaging: Probe improvement and real-time graphical user interface

2020 ◽  
Vol 245 (4) ◽  
pp. 321-329 ◽  
Author(s):  
Jeesu Kim ◽  
Eun-Yeong Park ◽  
Byullee Park ◽  
Wonseok Choi ◽  
Ki J Lee ◽  
...  
Keyword(s):  
User Interface ◽  
Real Time ◽  
Ultrasound Imaging ◽  
Graphical User Interface ◽  
Imaging System ◽  
Photoacoustic Imaging ◽  
Clinical Applications ◽  
Imaging Systems ◽  
Imaging Probe ◽  
Conventional Ultrasound

Photoacoustic imaging is a non-invasive and non-ionizing biomedical technique that has been investigated widely for various clinical applications. By taking the advantages of conventional ultrasound imaging, hand-held operation with a linear array transducer should be favorable for successful clinical translation of photoacoustic imaging. In this paper, we present new key updates contributed to the previously developed real-time clinical photoacoustic and ultrasound imaging system for improving the clinical usability of the system. We developed a seamless image optimization platform, designed a real-time parameter control software with a user-friendly graphical user interface, performed Monte Carlo simulation of the optical fluence in the imaging plane, and optimized the geometry of the imaging probe. The updated system allows optimizing of all imaging parameters while continuously acquiring the photoacoustic and ultrasound images in real-time. The updated system has great potential to be used in a variety of clinical applications such as assessing the malignancy of thyroid cancer, breast cancer, and melanoma. Impact statement Photoacoustic imaging is a promising biomedical imaging modality that can visualize both structural and functional information of biological tissue. Because of its easiness to be integrated with conventional ultrasound imaging systems, numerous studies have been conducted to develop and apply clinical photoacoustic imaging systems. However, most of the systems were not suitable for general-purpose clinical applications due to one of the following reasons: target specific design, immobility, inaccessible operation sequence, and lack of hand-held operation. This study demonstrates a real-time clinical photoacoustic and ultrasound imaging system, which can overcome the limitations of the previous systems for successful clinical translation.

scholarly journals Two-photon deep-tissue spatially resolved mitochondrial imaging using membrane potential fluorescence fluctuations

2017 ◽  
Vol 9 (1) ◽  
pp. 254 ◽  
Author(s):  
Kayvan Forouhesh Tehrani ◽  
Emily G. Pendleton ◽  
William M. Southern ◽  
Jarrod A. Call ◽  
Luke J. Mortensen
Keyword(s):  
Membrane Potential ◽  
Deep Tissue ◽  
Two Photon ◽  
Spatially Resolved

scholarly journals Special Issue: Novel Methods for Labeling Nanomaterials for Biological and Environmental Tracing Radiolabeling of Nanomaterials: Advantages and Challenges

2021 ◽  
Vol 3 ◽  
Author(s):  
Wanqin Dai ◽  
Junzhe Zhang ◽  
Yun Wang ◽  
Chunlei Jiao ◽  
Zhuda Song ◽  
...  
Keyword(s):  
Real Time ◽  
High Reliability ◽  
High Sensitivity ◽  
Clinical Applications ◽  
Special Issue ◽  
Complex Samples ◽  
Non Invasive ◽  
Spatially Resolved ◽  
Toxicological Research ◽  
The Stability

Quantifying the distribution of nanomaterials in complex samples is of great significance to the toxicological research of nanomaterials as well as their clinical applications. Radiotracer technology is a powerful tool for biological and environmental tracing of nanomaterials because it has the advantages of high sensitivity and high reliability, and can be matched with some spatially resolved technologies for non-invasive, real-time detection. However, the radiolabeling operation of nanomaterials is relatively complicated, and fundamental studies on how to optimize the experimental procedures for the best radiolabeling of nanomaterials are still needed. This minireview looks back into the methods of radiolabeling of nanomaterials in previous work, and highlights the superiority of the “last-step” labeling strategy. At the same time, the problems existing in the stability test of radiolabeling and the suggestions for further improvement are also addressed.

Stimulated Raman process in a scattering medium applied to the quantum memory scheme

2008 ◽  
Vol 78 (4) ◽  
Author(s):  
O. S. Mishina ◽  
N. V. Larionov ◽  
A. S. Sheremet ◽  
I. M. Sokolov ◽  
D. V. Kupriyanov
Keyword(s):  
Quantum Memory ◽  
Scattering Medium ◽  
Raman Process ◽  
Memory Scheme ◽  
Stimulated Raman
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