Role of Cation in Enhancing the Conversion of the Alzheimer’s Peptide into Amyloid Fibrils Using Protic Ionic Liquids

2012 ◽  
Vol 65 (11) ◽  
pp. 1502 ◽  
Author(s):  
Natalie Debeljuh ◽  
Swapna Varghese ◽  
Colin J. Barrow ◽  
Nolene Byrne
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Primary Amine ◽  
Amyloid Fibrils ◽  
Tertiary Amines ◽  
Protic Ionic Liquids ◽  
Protic Ionic Liquid ◽  
The Difference ◽  
The Impact

We report on the impact of changes in the protic ionic liquid (pIL) cation on the fibrilisation kinetics and the conversion of the Aβ 16–22 from monomers to amyloid fibrils. When we compare the use of primary, secondary, and tertiary amines we find that the primary amine results in the greatest conversion into amyloid fibrils. We show that the pIL is directly interacting with the peptide and this likely drives the difference in conversion and kinetics observed.

scholarly journals Effect of Ionicity of Three Protic Ionic Liquids as Neat Lubricants and Lubricant Additives to a Biolubricant

Coatings ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 713 ◽  
Author(s):  
Hong Guo ◽  
Angela Rina Adukure ◽  
Patricia Iglesias
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Friction And Wear ◽  
Cost Effective ◽  
Lubricant Additive ◽  
Lubricant Additives ◽  
Environmental Damage ◽  
Protic Ionic Liquids ◽  
Protic Ionic Liquid ◽  
Wear Process

Friction and wear of sliding surfaces are responsible for important energy losses and negative environmental effects. The use of environmentally friendly and cost-effective protic ionic liquids as neat lubricants and lubricant additives has the potential to increase the efficiency and durability of mechanical components without increasing the environmental damage. In this work, three halogen-free protic ionic liquids with increasing extent of ionicity, 2-hydroxyethylammonium 2-ethylhexanoate, 2-hydroxymethylammonium 2-ethylhexancate, and 2-hydroxydimethylammonium 2-ethylhexanoate, were synthesized and studied as neat lubricants and additives to a biodegradable oil in a steel–steel contact. The results show that the use of any protic ionic liquid as a neat lubricant or lubricant additive reduced friction and wear with respect to the biodegradable oil. The ionic liquid with the lowest ionicity reached the highest wear reduction. The one possessing the highest ionicity presented the poorest friction and wear behaviors as a neat lubricant, probably due to the more ionic nature of this liquid, which promoted tribocorrosion reactions on the steel surface. This ionic liquid performed better as an additive, showing that a small addition of this liquid in a biodegradable oil is enough to form protective layers on steel surfaces. However, it is not enough to accelerate the wear process with detrimental tribocorrosion reactions.

scholarly journals Lyotropic liquid crystal phase behavior of a cationic amphiphile in aqueous and non-stoichiometric protic ionic liquid mixtures

Soft Matter ◽  
2020 ◽  
Vol 16 (41) ◽  
pp. 9456-9470
Author(s):  
Dilek Yalcin ◽  
Calum J. Drummond ◽  
Tamar L. Greaves
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Liquid Crystal ◽  
Self Assembly ◽  
Liquid Mixtures ◽  
Lyotropic Liquid Crystal ◽  
Liquid Crystal Phase ◽  
Protic Ionic Liquids ◽  
Protic Ionic Liquid ◽  
Cationic Amphiphile

Protic ionic liquids (PILs) are the largest and most tailorable known class of non-aqueous solvents which possess the ability to support amphiphile self-assembly.

scholarly journals The beneficial effect of protic ionic liquids on the lithium environment in electrolytes for battery applications

2014 ◽  
Vol 2 (22) ◽  
pp. 8258-8265 ◽  
Author(s):  
Thomas Vogl ◽  
Sebastian Menne ◽  
Ruben-Simon Kühnel ◽  
Andrea Balducci
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Beneficial Effect ◽  
Lithium Ion Batteries ◽  
Lithium Ion ◽  
Protic Ionic Liquids ◽  
Protic Ionic Liquid

Protic ionic liquid-based electrolytes are promising electrolytes for lithium-ion batteries.

Ionothermal synthesis of crystalline metal phosphites using multifunctional protic ionic liquids

CrystEngComm ◽  
2020 ◽  
Vol 22 (37) ◽  
pp. 6096-6100
Author(s):  
Ting Li ◽  
Yumei Mao ◽  
Yue Qi ◽  
Hongmei Zeng ◽  
Guohong Zou ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Mixed Valence ◽  
Reducing Agent ◽  
Protic Ionic Liquids ◽  
Protic Ionic Liquid ◽  
Structure Directing Agent ◽  
Ionothermal Synthesis ◽  
Phosphorus Source ◽  
Crystalline Metal

A mixed-valence iron phosphite was prepared under ionothermal conditions using a protic ionic liquid as a solvent, a structure-directing agent, a phosphorus source, and a reducing agent.

scholarly journals A methanol and protic ionic liquid Ugi multicomponent reaction path to cytotoxic α-phenylacetamido amides

RSC Advances ◽  
2019 ◽  
Vol 9 (14) ◽  
pp. 7652-7663 ◽  
Author(s):  
Ahmed Al Otaibi ◽  
Fiona M. Deane ◽  
Cecilia C. Russell ◽  
Lacey Hizartzidis ◽  
Siobhann N. McCluskey ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Multicomponent Reaction ◽  
Reaction Path ◽  
Ugi Reaction ◽  
Protic Ionic Liquids ◽  
Protic Ionic Liquid ◽  
Ethanoic Acid ◽  
Ethylammonium Nitrate

The Ugi reaction (aldehyde, amine, isocyanide and an ethanoic acid) in the protic ionic liquids ethylammonium nitrate (EAN) and propylammonium nitrate (PAN) gave excellent yields of α-phenylacetamido amides.

scholarly journals The use of protic ionic liquids with cathodes for sodium-ion batteries

2016 ◽  
Vol 4 (27) ◽  
pp. 10472-10478 ◽  
Author(s):  
T. Vogl ◽  
C. Vaalma ◽  
D. Buchholz ◽  
M. Secchiaroli ◽  
R. Marassi ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Sodium Ion ◽  
Sodium Ion Batteries ◽  
Protic Ionic Liquids ◽  
Protic Ionic Liquid

Protic ionic liquid-based electrolytes are promising electrolytes for sodium-ion batteries.

scholarly journals The Structure of the Electric Double Layer of the Protic Ionic Liquid [Dema][TfO] Analyzed by Atomic Force Spectroscopy

2021 ◽  
Vol 22 (23) ◽  
pp. 12653
Author(s):  
Christian Rodenbücher ◽  
Yingzhen Chen ◽  
Klaus Wippermann ◽  
Piotr M. Kowalski ◽  
Margret Giesen ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Double Layer ◽  
Electric Double Layer ◽  
Force Spectroscopy ◽  
Protic Ionic Liquids ◽  
Protic Ionic Liquid ◽  
Atomic Force Spectroscopy ◽  
Atomic Force ◽  
Acidic Ionic Liquids

Protic ionic liquids are promising electrolytes for fuel cell applications. They would allow for an increase in operation temperatures to more than 100 °C, facilitating water and heat management and, thus, increasing overall efficiency. As ionic liquids consist of bulky charged molecules, the structure of the electric double layer significantly differs from that of aqueous electrolytes. In order to elucidate the nanoscale structure of the electrolyte–electrode interface, we employ atomic force spectroscopy, in conjunction with theoretical modeling using molecular dynamics. Investigations of the low-acidic protic ionic liquid diethylmethylammonium triflate, in contact with a platinum (100) single crystal, reveal a layered structure consisting of alternating anion and cation layers at the interface, as already described for aprotic ionic liquids. The structured double layer depends on the applied electrode potential and extends several nanometers into the liquid, whereby the stiffness decreases with increasing distance from the interface. The presence of water distorts the layering, which, in turn, significantly changes the system’s electrochemical performance. Our results indicate that for low-acidic ionic liquids, a careful adjustment of the water content is needed in order to enhance the proton transport to and from the catalytic electrode.

One-pot integrated biofuel production using low-cost biocompatible protic ionic liquids

2017 ◽  
Vol 19 (13) ◽  
pp. 3152-3163 ◽  
Author(s):  
Jian Sun ◽  
N. V. S. N. Murthy Konda ◽  
Ramakrishnan Parthasarathi ◽  
Tanmoy Dutta ◽  
Marat Valiev ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Cellulosic Ethanol ◽  
Low Cost ◽  
Biofuel Production ◽  
Protic Ionic Liquids ◽  
Protic Ionic Liquid ◽  
One Pot ◽  
Solid Liquid ◽  
Liquid Separations

We present an inexpensive and biocompatible protic ionic liquid that enables one-pot integrated cellulosic ethanol production without any pH adjustments and without water-wash or solid–liquid separations.

Dynamical heterogeneities in ionic liquids as revealed from deuteron NMR

2018 ◽  
Vol 54 (25) ◽  
pp. 3098-3101 ◽  
Author(s):  
Alexander E. Khudozhitkov ◽  
Peter Stange ◽  
Anne-Marie Bonsa ◽  
Viviane Overbeck ◽  
Andreas Appelhagen ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Nmr Spectroscopy ◽  
Suitable Method ◽  
Protic Ionic Liquids ◽  
Protic Ionic Liquid ◽  
Deuteron Nmr

Deuteron NMR spectroscopy is a suitable method to study dynamical heterogeneities in protic ionic liquids. In the 2H spectra of the protic ionic liquid [TEA][OTf] we observe anisotropic and isotropic signals at the same time.

scholarly journals Vapor-liquid equilibrium of the ionic liquid 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-enium acetate and its mixtures with water

2019 ◽  
Author(s):  
Zachariah Baird ◽  
Petri Uusi-Kyyny ◽  
Ville Alopaeus ◽  
Joanna Witos ◽  
Antti Rantamäki ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Raw Materials ◽  
Stoichiometric Ratio ◽  
Protic Ionic Liquids ◽  
Liquid Equilibrium ◽  
Protic Ionic Liquid ◽  
Vapor Liquid Equilibrium ◽  
Acid And Base ◽  
Vapor Liquid

Ionic liquids have the potential to be used for extracting valuable chemicals from raw materials. These processes often involve water, and after extraction the water, or other chemicals, must be removed from the ionic liquid so it can be reused. To help in designing such processes, we present data on the vapor-liquid equilibrium of the system containing the protic ionic liquid 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-enium acetate, water, acetic acid, and 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene. Earlier studies have only focused on mixtures of water and an ionic liquid with a stoichiometric ratio of the ions. Here we also investigated mixtures containing an excess of the acid or base component because in real systems with protic ionic liquids the amount of acid and base in the mixture can vary. We modeled the data using both the ePC-SAFT and NRTL models, and we compared the performance of different modeling strategies. We also experimentally determined the vapor composition for a few of the samples, but none of the modeling strategies tested could accurately predict the concentration of the acid and base components in the vapor phase.

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