A Multi-Step Continuous Flow Process for the N-Demethylation of Alkaloids

2013 ◽  
Vol 66 (2) ◽  
pp. 178 ◽  
Author(s):  
Yuji Nakano ◽  
G. Paul Savage ◽  
Simon Saubern ◽  
Peter J. Scammells ◽  
Anastasios Polyzos
Keyword(s):  
Continuous Flow ◽  
Flow Conditions ◽  
Flow Process ◽  
Continuous Flow Process

Dextromethorphan was N-demethylated using the non-classical Polonovski reaction under continuous flow conditions, in two steps: initial N-oxidation with m-chloroperbenzoic acid followed by iron-catalysed N-demethylation of the resulting N-oxide.

scholarly journals A Continuous-Flow, Two-Step, Metal-Free Process for the Synthesis of Differently Substituted Chiral 1,2-Diamino Derivatives

Synthesis ◽  
2018 ◽  
Vol 50 (07) ◽  
pp. 1430-1438
Author(s):  
Maurizio Benaglia ◽  
Margherita Pirola ◽  
Maria Compostella ◽  
Laura Raimondi ◽  
Alessandra Puglisi
Keyword(s):  
Continuous Flow ◽  
Catalytic Synthesis ◽  
Flow Conditions ◽  
Reaction Conditions ◽  
Flow Process ◽  
Preliminary Screening ◽  
Metal Free ◽  
Free Process ◽  
Continuous Flow Process ◽  
Nitro Reduction

The enantioselective organocatalytic reduction of aryl-substituted nitroenamines was successfully performed under continuous-flow conditions. After a preliminary screening with a 10-μL microreactor, to establish the best reaction conditions, the reduction was scaled up in a 0.5-mL mesoreactor, without appreciable loss of enantioselectivity, that remained constantly higher than 90%. The in-flow nitro reduction was also accomplished, either by Raney nickel catalyzed hydrogenation or by a metal-free methodology based on the use of the very inexpensive and readily available reducing agent trichlorosilane. The final aim is to develop a two-step, continuous-flow process for the stereo­selective, metal-free, catalytic synthesis of differently functionalized chiral 1,2-diamines.

A Continuous Flow Process for LSN647712 via Double Organometallic Additions to Dimethylcarbamyl Chloride

2021 ◽  
Author(s):  
Hui Li ◽  
Jillian W. Sheeran ◽  
David Kouvchinov ◽  
Andrew M. Clausen ◽  
Ian T. Crouch ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Process ◽  
Continuous Flow Process

Assessing inter- and intramolecular continuous-flow strategies towards methylphenidate (Ritalin) hydrochloride

2017 ◽  
Vol 2 (2) ◽  
pp. 149-158 ◽  
Author(s):  
Romaric Gérardy ◽  
Marc Winter ◽  
Alessandra Vizza ◽  
Jean-Christophe M. Monbaliu
Keyword(s):  
Continuous Flow ◽  
Flow Process ◽  
Continuous Flow Process

Development of a scalable continuous-flow process towards enriched threo-methylphenidate (Ritalin) hydrochloride.

Continuous-Flow Process for Selective Mononitration of 1-Methyl-4-(methylsulfonyl)benzene

2016 ◽  
Vol 20 (2) ◽  
pp. 199-203 ◽  
Author(s):  
Zhiqun Yu ◽  
Pengcheng Zhou ◽  
Jiming Liu ◽  
Wenzuo Wang ◽  
Chuanming Yu ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Process ◽  
Continuous Flow Process

Continuous Flow Process for Reductive Deoxygenation of ω-Chloroketone in the Synthesis of Vilazodone

2018 ◽  
Vol 22 (8) ◽  
pp. 1022-1028 ◽  
Author(s):  
Avedis Karadeolian ◽  
Dineshkumar Patel ◽  
Prabhudas Bodhuri ◽  
Gamini Weeratunga ◽  
Boris Gorin
Keyword(s):  
Continuous Flow ◽  
Flow Process ◽  
Continuous Flow Process

Continuous flow synthesis of amine oxides by oxidation of tertiary amines

2019 ◽  
Vol 4 (7) ◽  
pp. 1270-1276
Author(s):  
Tobias Baumeister ◽  
Stefan Zikeli ◽  
Hannes Kitzler ◽  
Paul Aigner ◽  
Piotr P. Wieczorek ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Continuous Flow ◽  
Tertiary Amines ◽  
Flow Process ◽  
Flow Synthesis ◽  
Amine Oxides ◽  
Continuous Flow Process

An efficient, safe and scalable continuous flow process for the synthesis of amine oxides with hydrogen peroxide is described.

Development of a Continuous Flow Process for a Matteson Reaction: From Lab Scale to Full-Scale Production of a Pharmaceutical Intermediate

2019 ◽  
Vol 23 (5) ◽  
pp. 1069-1077 ◽  
Author(s):  
Clemens Stueckler ◽  
Peter Hermsen ◽  
Bas Ritzen ◽  
Maria Vasiloiu ◽  
Peter Poechlauer ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Full Scale ◽  
Scale Production ◽  
Flow Process ◽  
Continuous Flow Process

Design of a microfluidic device for the measurement of the elastic modulus of deformable particles

Soft Matter ◽  
2019 ◽  
Vol 15 (5) ◽  
pp. 880-889 ◽  
Author(s):  
Massimiliano M. Villone ◽  
Janine K. Nunes ◽  
Yankai Li ◽  
Howard A. Stone ◽  
Pier Luca Maffettone
Keyword(s):  
Elastic Modulus ◽  
Interfacial Tension ◽  
Continuous Flow ◽  
Liquid Droplet ◽  
Flow Process ◽  
Deformable Particles ◽  
Soft Particles ◽  
Continuous Flow Process ◽  
Microfluidic Technique

A microfluidic technique recently proposed in the literature to measure the interfacial tension between a liquid droplet and an immiscible suspending liquid [Hudson et al., Appl. Phys. Lett., 2005, 87, 081905], [Cabral and Hudson, Lab Chip, 2006, 6, 427] is suitably adapted to the characterization of the elastic modulus of soft particles in a continuous-flow process.

Effective production of the biodiesel additive STBE by a continuous flow process

2011 ◽  
Vol 102 (19) ◽  
pp. 9304-9307 ◽  
Author(s):  
Jean-Christophe M. Monbaliu ◽  
Marc Winter ◽  
Bérengère Chevalier ◽  
Frank Schmidt ◽  
Yi Jiang ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Process ◽  
Continuous Flow Process
Sign in / Sign up

Export Citation Format

Share Document