The H.G. Smith Award Article: Fluorescent Analogues of NAMI-A: Synthesis, Characterisation, Fluorescent Properties, and Preliminary Biological Studies in Human Lung Cancer Cells

2014 ◽  
Vol 67 (12) ◽  
pp. 1711 ◽  
Author(s):  
Sumy Antony ◽  
Jonathan C. Morris ◽  
Toby D. M. Bell ◽  
Tracey Brown ◽  
Leone Spiccia ◽  
...  
Keyword(s):  
A549 Cells ◽  
Fluorescence Emission ◽  
Emission Spectra ◽  
Fluorescence Probes ◽  
Human Lung Cancer ◽  
Fluorescent Properties ◽  
Fluorescence Emission Spectra ◽  
Biological Studies ◽  
Ru Complexes ◽  
Fluorescent Analogues

Two new fluorescent ruthenium(iii) complexes, namely 7-azaindolium trans-tetrachlorido(7-azaindole)(dimethylsulfoxide)ruthen(iii)ate (F1) and N-[histaminedihydrolium]-1,8-naphthalenecarboximidic trans-tetracholoro(dimethylsulfoxide)(N-[histaminedihydro]-1,8-naphthalenecarboximide)ruthen(iii)ate (F2) and their respective tetramethylammonium analogues (F3 and F4) are reported herein. The compounds were characterised by elemental analysis, mass spectrometry, UV-vis spectrophotometry, and fluorescence spectroscopy. Molar extinction coefficients (ϵmax) and fluorescence emission spectra were compared to evaluate the electronic properties of the synthesised fluorescent analogues, and hence their value as intracellular fluorescence probes. F3 and F4 were synthesised and characterised in order to eliminate fluorescence arising from the counter-cations in F1 and F2 and thus to obtain a fluorescence quantum yield that reflects only a contribution from the metal complex anion. Half-inhibitory concentrations (IC50) were determined for A549 cells exposed to the Ru complexes for 24 h: F3 (203 ± 26 μM) and F4 (185 ± 20 μM).

scholarly journals Luminescent Hybrid Materials Based on Curcumin Derivatives Embedded in Palygorskite

2018 ◽  
Vol 55 (1) ◽  
pp. 63-67
Author(s):  
Monica Florentina Raduly ◽  
Valentin Raditoiu ◽  
Alina Raditoiu ◽  
Luminita Eugenia Wagner ◽  
Viorica Amariutei ◽  
...  
Keyword(s):  
Hybrid Materials ◽  
Fluorescence Spectra ◽  
Fluorescence Emission ◽  
Emission Spectra ◽  
Hydroxyl Groups ◽  
Fluorescent Properties ◽  
Fluorescence Emission Spectra ◽  
Curcumin Derivatives ◽  
Absorption Studies ◽  
Inorganic Matrix

The seven curcumin derivatives were deposited on palygorskite in order to obtain hybrid materials. The fluorescence emission spectra of the obtained materials show a decrease in fluorescence intensity relative to the respective dyes, due to the environments around the dyestuff molecules created in the host matrices. Absorption studies show the best adsorption on the inorganic matrix, for the compounds with the hydroxyl groups. Correlating fluorescence spectra of hybrid materials with the results for absorption spectra of the dyes adsorbtion on the surface of the clay lead to the conclusion that a high percentage of the adsorbed dye had the effect of fluorescence quenching. Thus, it was confirmed that the fluorescent properties of hybrid materials depend on the interactions established between the fluorescent dyestuff and the inorganic network.

Influence of trimethoxy-substituted positions on fluorescence of heteroaryl chalcone derivatives

2011 ◽  
Vol 65 (6) ◽  
Author(s):  
Thitipone Suwunwong ◽  
Suchada Chantrapromma ◽  
Hoong-Kun Fun
Keyword(s):  
Aldol Condensation ◽  
Fluorescence Emission ◽  
Emission Spectra ◽  
Fluorescent Properties ◽  
Fluorescence Emission Spectra ◽  
Strong Emission ◽  
X Ray ◽  
Methoxy Groups ◽  
Phenyl Rings ◽  
Ft Ir

AbstractThree series of heteroaryl chalcones, (E)-1-(2-pyridyl)-3-(X)prop-2-en-1-one (Ia-Ic), (E)-1-(2-thienyl)-3-(X)prop-2-en-1-one (IIa-IIc), and (E)-1-(2-furyl)-3-(X)prop-2-en-1-one (IIIa-IIIc), where X = 2,4,5-trimethoxyphenyl (for series a), X = 2,4,6-trimethoxyphenyl (for series b), and X = 3,4,5-trimethoxyphenyl (for series c) were synthesised using basic catalysed aldol condensation and characterised using 1H NMR and FT-IR spectroscopies. Compound IIa was also characterised by single crystal X-ray analysis. The absorption and fluorescence emission spectra of these compounds revealed that the absorption and fluorescence depended on the heterocycle rings and trimethoxysubstituted phenyl rings linked to the enone system. The position of methoxy groups substantially affected the fluorescent properties. Compounds Ia-IIIa containing the 2,4,5-trimethoxyphenyl moiety exhibited the red-shift phenomenon and strong emission fluorescence.

Synthesis, characterization, fluorescence and redox features of new vic-dioxime ligand bearing pyrene and its metal complexes

2008 ◽  
Vol 62 (4) ◽  
Author(s):  
Ismail Yilmaz ◽  
Ahmet Kilic ◽  
Hacer Yalcinkaya
Keyword(s):  
Metal Complexes ◽  
Metal Binding ◽  
Fluorescence Emission ◽  
Emission Spectra ◽  
Fluorescent Properties ◽  
Fluorescence Emission Spectra ◽  
1H And 13C Nmr ◽  
Mononuclear Complexes ◽  
Square Planar ◽  
Elemental Analyses

AbstractA new vic-dioxime ligand, N,N′-bis(aminopyreneglyoxime) (LH2), and its copper(II), nickel(II) and cobalt(II) metal complexes were synthesized and characterized by elemental analyses, IR, UVVIS and 1H and 13C NMR spectra (for the ligand). Mononuclear complexes were synthesized by a reaction of ligand (LH2) and salts of Co(II), Ni(II), and Cu(II) in ethanol. The complexes have the metal-ligand ratio of 1: 2 and metals are coordinated by N,N′ atoms of vicinal dioximes. The ligand acts in a polydentate fashion bending through nitrogen atoms in the presence of a base, as do most vic-dioximes. Detection of a H-bonding in the Co(II), Ni(II), and Cu(II) complexes by IR revealed the square-planar MN4 coordination of mononuclear complexes. Fluorescent properties of the ligand and its complexes arise from pyrene units conjugated with a vic-dioxime moiety. Fluorescence emission spectra of the ligand showed a drastic decrease in its fluorescence intensity upon metal binding. The electrochemical properties of the complexes were studied by the cyclic voltammetry technique. The nickel complex displayed an irreversible oxidation process while the copper complex exhibited a quasi-reversible oxidation and reduction processes based on the copper Cu(II)/Cu(III) and Cu(II)/Cu(I) couples, respectively.

scholarly journals Non-Typical Fluorescence Effects and Biological Activity in Selected 1,3,4-thiadiazole Derivatives: Spectroscopic and Theoretical Studies on Substituent, Molecular Aggregation, and pH Effects

2019 ◽  
Vol 20 (21) ◽  
pp. 5494 ◽  
Author(s):  
Budziak ◽  
Karcz ◽  
Makowski ◽  
Rachwał ◽  
Starzak ◽  
...  
Keyword(s):  
Charge Transfer ◽  
Density Functional ◽  
Fluorescence Emission ◽  
Emission Spectra ◽  
Ph Effects ◽  
Molecular Aggregation ◽  
Dual Fluorescence ◽  
Fluorescence Emission Spectra ◽  
Biological Studies ◽  
Td Dft

The below article presents the results of spectroscopic research, theoretical (time-dependent density functional theory (TD-DFT)), microbiological, and antioxidative calculations for three compounds from the group of 1,3,4-thiadiazoles: 2-amino-5-phenyl-1,3,4-thiadiazole (TB), 2-amino-5-(2-hydroxyphenyl)-1,3,4-thiadiazole (TS), 2-amino-5-(2-hydroxy-5-sulfobenzoyl)-1,3,4-thiadiazole (TSF). In the fluorescence emission spectra (TS) of solutions with varying concentrations of hydrogen ions, a particularly interesting effect of dual fluorescence was observed. The aforementioned effect was observed even more clearly in the environment of butan-1-ol, relative to the compound’s concentration. Depending on the modification of the resorcylic substituent (TS and TSF), we observed the emergence of two separate, partially overlapping, fluorescence emission spectra or a single emission spectrum. Interpretation of the obtained spectra using stationary and time-resolved spectroscopy allowed the correlation of the effect’s emergence with the phenomenon of molecular aggregation (of a particular type) as well as, above all, the structure of the substituent system. The overlap of said effects most likely induces the processes related to the phenomenon of charge transfer (in TS) and is responsible for the observed fluorescence effects. Also, the position of the –OH group (in the resorcylic ring) is significant and can facilitate the charge transfer (CT). The determinations of the changes in the dipole moment and TD-DFT calculations further corroborate the above assumption. The following paper presents the analysis (the first for this particular group of analogues) of the fluorescence effects relative to the changes in the structure of the resorcylic group combined with pH effects. The results of biological studies also indicate the highest pharmacological potential of the analogue in the case where the effects of dual fluorescence emission are observed, which predisposes this particular group of fluorophores as effective fluorescence probes or potential pharmaceuticals with antimycotic properties.

Optical Properties and Zinc Nitride Thin Films Prepared Using Magnetron Reactive Sputtering

2014 ◽  
Vol 940 ◽  
pp. 11-15
Author(s):  
Jun Qin Feng ◽  
Jun Fang Chen
Keyword(s):  
Thin Films ◽  
Band Gap ◽  
Near Infrared ◽  
Fluorescence Emission ◽  
Emission Spectra ◽  
Sem Images ◽  
Fluorescence Emission Spectra ◽  
Glass Substrates ◽  
Zinc Nitride ◽  
Direct Band

Zinc nitride films were deposited by ion sources-assisted magnetron sputtering with the use of Zn target (99.99% purity) on 7059 glass substrates. The films were characterized by XRD, SEM and EDS, the results of which show that the polycrystalline zinc nitride thin film can be grown on the glass substrates, the EDS spectrum confirmed the chemical composition of the films and the SEM images revealed that the zinc nitride thin films have a dense structure. Ultraviolet-visible-near infrared spectrophotometer was used to study the transmittance behaviors of zinc nitride thin films, which calculated the optical band gap by Davis Mott model. The results of the fluorescence emission spectra show the zinc nitride would be a direct band gap semiconductor material.

Stress and Phase Transformation Phenomena in Oxide Films: Real-Time Spectroscopic Measurements

1992 ◽  
Vol 271 ◽  
Author(s):  
Gregory J. Exarhos ◽  
Nancy J. Hess
Keyword(s):  
Phase Transformation ◽  
Applied Pressure ◽  
Oxide Films ◽  
Fluorescence Emission ◽  
Emission Spectra ◽  
Film Deposition ◽  
Optical Methods ◽  
Fluorescence Emission Spectra ◽  
Line Intensities ◽  
Deposition Parameters

ABSTRACTIn situ optical methods are reviewed for characterization of phase transformation processes and evaluation of residual stress in solution-deposited metastable oxide films. Such low density films most often are deposited as disordered phases making them prone to crystallization and attendant densification when subjected to increased temperature and/or applied pressure. Inherent stress imparted during film deposition and its evolution during the transformation are evaluated from phonon frequency shifts seen in Raman spectra (TiO2) or from changes in the laser-induced fluorescence emission spectra for films containing rare earth (Sm+3:Y3Al5O12) or transition metal (Cr+3 :Al2O3) dopants. The data in combination with measured increases in line intensities intrinsic to the evolving phase are used to follow crystallization processes in thin films. In general, film deposition parameters are found to influence the crystallite ingrowth kinetics and the magnitude of stress and stress relaxation in the film during the transformation. The utility of these methods to probe crystallization phenomena in oxide films will be addressed.

scholarly journals Fluorescence emission spectra of silver and silver/cobalt nanoparticles

2012 ◽  
Vol 19 (3) ◽  
pp. 943-947 ◽  
Author(s):  
Z. Parang ◽  
A. Keshavarz ◽  
S. Farahi ◽  
S.M. Elahi ◽  
M. Ghoranneviss ◽  
...  
Keyword(s):  
Fluorescence Emission ◽  
Emission Spectra ◽  
Cobalt Nanoparticles ◽  
Fluorescence Emission Spectra

pH sensitive smart gels of cetylpyridinium chloride in binary solvent mixtures: phase behaviour, structure and composition

RSC Advances ◽  
2015 ◽  
Vol 5 (62) ◽  
pp. 50306-50311 ◽  
Author(s):  
Illa Ramakanth ◽  
Jaromír Pištora
Keyword(s):  
Cetylpyridinium Chloride ◽  
Fluorescence Emission ◽  
Emission Spectra ◽  
Phase Behaviour ◽  
Binary Solvent ◽  
Solvent Mixtures ◽  
Gel Formation ◽  
Fluorescence Emission Spectra ◽  
Effect Of Ph ◽  
Binary Solvent Mixtures

Figure showing the effect of pH on CPC gel formation at 25 °C and fluorescence emission spectra of CPC solutions at pH ∼ 11.8.

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