The chemistry of 2,1-benzisothiazoles. IX. The reaction of 3-chloro-substituted 2,1-benzisothiazoles with nucleophiles and the preparation of(2,1-Benzisothiazol-3-yl)acetic acid
3-Chloro-2,1-benzisothiazole (2; R = H, R? = Cl) and 3,5-dichloro-2,1- benzisothiazole (2;R,R? = Cl) react readily with nucleophiles, and yield 3-substituted products. Acid hydrolysis of one such product, ethyl (2,1-benzisothiazol-3-yl)cyanoacetate (2; R = H, R? = CH(CN)CO2Et),affords (2,1-benzisothiazol-3-yl)acetic acid (2; R = H, R? = CH2CO2H), an auxin analogue.
1970 ◽
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1971 ◽
Vol 19
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pp. 357-367
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1980 ◽
Vol 58
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pp. 1751-1758
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1991 ◽
Vol 81
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pp. 51-54
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2017 ◽
Vol 4
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