Verification of the Chemical Weapons Convention: Mass Spectrometry of Alkyl Methylphosphonofluoridates

1994 ◽  
Vol 47 (11) ◽  
pp. 2065 ◽  
Author(s):  
VT Borrett ◽  
RJ Mathews ◽  
ER Mattsson

Under the provisions of the United Nations Chemical Weapons Convention (CWC), certain parts of chemical industry will be monitored to verify compliance with the Convention. This will include analysis of samples from industrial sites to check for the presence or absence of chemical warfare related compounds. One of the problems in screening the chemicals to be monitored under the CWC is that certain classes of chemical warfare agents are represented as families of chemicals, with many of the individual chemicals having no analytical data available. One example is the alkyl methylphosphonofluoridate family with an alkyl ester substituent from CH3 to C10H21. In this work, the mass spectra of 60 alkyl methylphosphonofluoridate family members have been studied to enable the development of rapid on-site screening methods for this family of chemicals.

2002 ◽  
Vol 74 (12) ◽  
pp. 2281-2291 ◽  
Author(s):  
H. H. Hill ◽  
S. J. Martin

Analytical methods that are currently used for the detection and identification of chemical warfare agents are reviewed and classified by the number of dimensions of information they provide. Single dimensional sensors target specific compounds or classes of compounds. Although they can be less expensive and more portable than multidimensional sensors, multidimensional sensors detect a broader threat spectrum with greater precision and accuracy. The recommendation for analytical field verification during inspections under the Chemical Weapons Convention (CWC) is to use simple two-dimensional analytical methods, such as gas chromatography (GC) or ion mobility spectrometry (IMS), for on-site screening of chemical weapons (CW) agents or to fully equip a modern, mobile analytical laboratory located in an airplane, which can be moved rapidly throughout the world to each inspection site and provide high-quality analytical data on-site.


Sensor Review ◽  
2015 ◽  
Vol 35 (3) ◽  
pp. 237-243 ◽  
Author(s):  
Robert Bogue

Purpose – The purpose of this paper is to provide details of recent developments in sensors for detecting explosives and chemical warfare agents. Design/methodology/approach – Following an introduction, this paper first discusses a selection of new sensing techniques aimed at detecting explosives and explosive devices. It then considers new developments in sensors for detecting chemical warfare agents. Brief concluding comments are drawn. Findings – This paper shows that a diversity of sensor technologies is being investigated, including various advanced optical methods, nanomaterials, microelectromechanical system, electronic noses, biosensors and electrochemical techniques, several of which offer levels of sensitivity in the parts-per-trillion region. These not only have the potential to yield improved devices for detecting explosives and chemical weapons but may also play a role in health care, environmental monitoring, drug detection and industrial health and safety. Originality/value – In an era of escalating terrorism and military conflicts, this provides a timely review of new technologies for detecting explosives and chemical warfare agents.


2017 ◽  
Vol 1 (2) ◽  
pp. 39-63

The introduction of poison gases by the Germans at Ypres in April 1915 marked a new era in modern warfare. The cylinder attack of the German Army against the French and the British positions at Ypres on April 22, 1915, became the first large-scale appearance of the new kind of weapons, chemical weapons, on the battlefields of World War 1. The widespread use of chemical munitions of different types, numerous toxic agents and their delivery systems (field and heavy artillery, mortars and Livens projectors) by all the belligerents influenced military tactics and operational art at World War 1. In 1915-1916, during the period of trench warfare, the use of chemical weapons for breaking through the enemy`s first defence lines changed the structure of combat orders and led to their dispersal and the deployment in depth of the defensive zone. In 1917 chemical weapons made it possible to overcome the contradiction between the lengthy preliminary artillery bombardment and the surprise of the offensive. The unprecedented artillery chemical bombardments fired by the German Army, artillery chemical battle, resulted in the significant success of the Germans in spring offensives in 1918, when large parts of the front were given up by the retiring Allied forces. The dynamics of the growth of the chemical warfare agents` (CWA) production, the development of means and methods for delivering the agents efficiently to the target by the Allied countries allowed the authors to suggest that in case Germany had not signed the armistice of 11 November 1918 with the Allies, the large-scale battlefield use of chemical weapons could multiply both in quality and in quantity. The development of the bombardment aviation and the inability of Germany to carry out a retaliatory chemical attack, that became obvious at the end of 1918, offered a golden opportunity for the Allies to use chemical agents in 1919 without any legal or humanitarian limitation on the methods of warfare. This article is concerned also with tactical and operational objectives and targets the belligerents tried to achieve by using chemical weapons during separate battles, the evolution of chemical weapons and chemical warfare agents and their joint impact on military operations at the battlefields of World War 1.


2017 ◽  
Vol 89 (10) ◽  
pp. 1491-1503 ◽  
Author(s):  
Igor V. Rybalchenko ◽  
Igor A. Rodin ◽  
Timur M. Baygildiev ◽  
Andrey N. Stavrianidi ◽  
Arcady V. Braun ◽  
...  

AbstractIn this paper a summary of the author’s approaches for investigation of the mass spectral behavior of some chemical warfare agents (CWAs), their degradation products and metabolites, as well as the results of development of analytical methods for confirmation of nerve and blister agents application are presented. Hydrolysis and oxidation metabolites of nerve agents, sulfur mustard and lewisite were used as biomarkers of the exposure. Sensitive analytical methods have been developed for their detection, based mainly on tandem mass spectrometry coupled with liquid chromatography. Several techniques for fast screening of CWAs degradation products based on capillary electrophoresis were also proposed. Some of developed approaches were successfully applied in the frame of the proficiency testing system of the Organization for the Prohibition of Chemical Weapons.


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