Conventional analytical methods for chemical warfare agents

2002 ◽  
Vol 74 (12) ◽  
pp. 2281-2291 ◽  
Author(s):  
H. H. Hill ◽  
S. J. Martin
Keyword(s):  
Ion Mobility ◽  
Analytical Methods ◽  
Analytical Data ◽  
Chemical Warfare Agents ◽  
Chemical Warfare ◽  
Chemical Weapons ◽  
Field Verification ◽  
Detection And Identification ◽  
Chemical Weapons Convention ◽  
Warfare Agents

Analytical methods that are currently used for the detection and identification of chemical warfare agents are reviewed and classified by the number of dimensions of information they provide. Single dimensional sensors target specific compounds or classes of compounds. Although they can be less expensive and more portable than multidimensional sensors, multidimensional sensors detect a broader threat spectrum with greater precision and accuracy. The recommendation for analytical field verification during inspections under the Chemical Weapons Convention (CWC) is to use simple two-dimensional analytical methods, such as gas chromatography (GC) or ion mobility spectrometry (IMS), for on-site screening of chemical weapons (CW) agents or to fully equip a modern, mobile analytical laboratory located in an airplane, which can be moved rapidly throughout the world to each inspection site and provide high-quality analytical data on-site.

Verification of the Chemical Weapons Convention: Mass Spectrometry of Alkyl Methylphosphonofluoridates

1994 ◽  
Vol 47 (11) ◽  
pp. 2065 ◽  
Author(s):  
VT Borrett ◽  
RJ Mathews ◽  
ER Mattsson
Keyword(s):  
Analytical Data ◽  
Chemical Warfare Agents ◽  
Chemical Warfare ◽  
Chemical Weapons ◽  
Screening Methods ◽  
Industrial Sites ◽  
Chemical Weapons Convention ◽  
Warfare Agents ◽  
The Individual ◽  
Related Compounds

Under the provisions of the United Nations Chemical Weapons Convention (CWC), certain parts of chemical industry will be monitored to verify compliance with the Convention. This will include analysis of samples from industrial sites to check for the presence or absence of chemical warfare related compounds. One of the problems in screening the chemicals to be monitored under the CWC is that certain classes of chemical warfare agents are represented as families of chemicals, with many of the individual chemicals having no analytical data available. One example is the alkyl methylphosphonofluoridate family with an alkyl ester substituent from CH3 to C10H21. In this work, the mass spectra of 60 alkyl methylphosphonofluoridate family members have been studied to enable the development of rapid on-site screening methods for this family of chemicals.

scholarly journals Novel analytical approaches to determination of chemical warfare agents and related compounds for verification of nonproliferation of chemical weapons

2017 ◽  
Vol 89 (10) ◽  
pp. 1491-1503 ◽  
Author(s):  
Igor V. Rybalchenko ◽  
Igor A. Rodin ◽  
Timur M. Baygildiev ◽  
Andrey N. Stavrianidi ◽  
Arcady V. Braun ◽  
...  
Keyword(s):  
Analytical Methods ◽  
Sulfur Mustard ◽  
Degradation Products ◽  
Chemical Warfare Agents ◽  
Chemical Warfare ◽  
Chemical Weapons ◽  
Mass Spectral ◽  
Fast Screening ◽  
Warfare Agents ◽  
Analytical Approaches

AbstractIn this paper a summary of the author’s approaches for investigation of the mass spectral behavior of some chemical warfare agents (CWAs), their degradation products and metabolites, as well as the results of development of analytical methods for confirmation of nerve and blister agents application are presented. Hydrolysis and oxidation metabolites of nerve agents, sulfur mustard and lewisite were used as biomarkers of the exposure. Sensitive analytical methods have been developed for their detection, based mainly on tandem mass spectrometry coupled with liquid chromatography. Several techniques for fast screening of CWAs degradation products based on capillary electrophoresis were also proposed. Some of developed approaches were successfully applied in the frame of the proficiency testing system of the Organization for the Prohibition of Chemical Weapons.

Detecting explosives and chemical weapons: a review of recent developments

Sensor Review ◽  
2015 ◽  
Vol 35 (3) ◽  
pp. 237-243 ◽  
Author(s):  
Robert Bogue
Keyword(s):  
New Technologies ◽  
Electrochemical Techniques ◽  
Health And Safety ◽  
Chemical Warfare Agents ◽  
Chemical Warfare ◽  
Optical Methods ◽  
Chemical Weapons ◽  
Content Type ◽  
Recent Developments ◽  
Warfare Agents

Purpose – The purpose of this paper is to provide details of recent developments in sensors for detecting explosives and chemical warfare agents. Design/methodology/approach – Following an introduction, this paper first discusses a selection of new sensing techniques aimed at detecting explosives and explosive devices. It then considers new developments in sensors for detecting chemical warfare agents. Brief concluding comments are drawn. Findings – This paper shows that a diversity of sensor technologies is being investigated, including various advanced optical methods, nanomaterials, microelectromechanical system, electronic noses, biosensors and electrochemical techniques, several of which offer levels of sensitivity in the parts-per-trillion region. These not only have the potential to yield improved devices for detecting explosives and chemical weapons but may also play a role in health care, environmental monitoring, drug detection and industrial health and safety. Originality/value – In an era of escalating terrorism and military conflicts, this provides a timely review of new technologies for detecting explosives and chemical warfare agents.

Ion Mobility Spectrometry and Its Applications in Detection of Chemical Warfare Agents

2010 ◽  
Vol 82 (23) ◽  
pp. 9594-9600 ◽  
Author(s):  
Marko A. Mäkinen ◽  
Osmo A. Anttalainen ◽  
Mika E. T. Sillanpää
Keyword(s):  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Chemical Warfare Agents ◽  
Chemical Warfare ◽  
Warfare Agents

Differential Ion Mobility Spectrometry in Application to the Analysis of Gases and Vapours

2014 ◽  
Vol 223 ◽  
pp. 283-290 ◽  
Author(s):  
Mirosław Maziejuk ◽  
Wiesław Lisowski ◽  
Monika Szyposzyńska ◽  
Tomasz Sikora ◽  
Anna Zalewska
Keyword(s):  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Chemical Warfare Agents ◽  
Chemical Warfare ◽  
Differential Ion Mobility Spectrometry ◽  
Alternating Electric Field ◽  
Different Types ◽  
Warfare Agents ◽  
Industrial Compounds ◽  
Alpha Function

Ion mobility spectrometry (IMS) is a technique used for the detection of chemical warfare agents (CWA), drugs, toxic industrial compounds (TIC), and explosives, when rapid detection should be performed (from a few to several seconds) for trace amounts of these substances. An important development of IMS technology is differential ion mobility spectrometry (DMS). DMS is also known as Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS). Detection possibilities of apparatus using the DMS method are based on the occurrence of the different mobilities of ions (K) in the alternating electric field. This dependence is characterized by the alpha function (α).This presentation shows methods and examples of the identification of chosen substances. The results for the dependence of coefficient α are specific for different types of substances. This specificity is used to identify vapours and gases.

Ion Mobility Spectrometry for Monitoring Chemical Warfare Agents

2012 ◽  
Vol 241-244 ◽  
pp. 980-983 ◽  
Author(s):  
Jian Zheng ◽  
Tian Min Shu ◽  
Jie Jin
Keyword(s):  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Cluster Formation ◽  
Chemical Warfare Agents ◽  
Chemical Warfare ◽  
Ambient Conditions ◽  
Ionization Source ◽  
Warfare Agents ◽  
Positive Mode ◽  
Detecting Method

The technique of ion mobility spectrometry (IMS) offers a practical and fast detecting method in ambient conditions to estimate whether there may presence contrabands or even chemical warfare agents (CWAs). In this work we have investigated a self-made radioactive 63Ni (β emission) ionization source for ion mobility spectrometry employed with an atmospheric pressure to detect real CWAs, such as GB, GD, HD, VX from aerosol samples. Furthermore, we have experimentally studied the influence of drift tube temperature not only in ion cluster formation in the positive mode, but also the detection limitation of CWAs.

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