Long-term survival outcome following Staphylococcus aureus bacteraemia

2013 ◽  
Vol 18 (3) ◽  
pp. 102-109 ◽  
Author(s):  
Chong W. Ong ◽  
Jan L. Roberts ◽  
Peter J. Collignon
Keyword(s):  
Staphylococcus Aureus ◽  
Survival Outcome ◽  
Term Survival ◽  
Long Term Survival

An oncology clinical trial design with randomization adaptive to both short- and long-term responses

2017 ◽  
Vol 28 (7) ◽  
pp. 2015-2031 ◽  
Author(s):  
Hao Liu ◽  
Xiao Lin ◽  
Xuelin Huang
Keyword(s):  
Trial Design ◽  
Clinical Trial Design ◽  
Therapeutic Benefit ◽  
Survival Outcome ◽  
Operating Characteristics ◽  
Short Term ◽  
Term Survival ◽  
Long Term Survival ◽  
Term Response

In oncology clinical trials, both short-term response and long-term survival are important. We propose an urn-based adaptive randomization design to incorporate both of these two outcomes. While short-term response can update the randomization probability quickly to benefit the trial participants, long-term survival outcome can also change the randomization to favor the treatment arm with definitive therapeutic benefit. Using generalized Friedman’s urn, we derive an explicit formula for the limiting distribution of the number of subjects assigned to each arm. With prior or hypothetical knowledge on treatment effects, this formula can be used to guide the selection of parameters for the proposed design to achieve desirable patient number ratios between different treatment arms, and thus optimize the operating characteristics of the trial design. Simulation studies show that the proposed design successfully assign more patients to the treatment arms with either better short-term tumor response or long-term survival outcome or both.

scholarly journals Gastric Mucinous Cancer Histology: Clinicopathological Characteristics and Prognostic Value

2016 ◽  
Vol 2016 ◽  
pp. 1-9
Author(s):  
Chen Jian-Hui ◽  
Cai Shi-Rong ◽  
Wu Hui ◽  
Xu Jian-bo ◽  
Wu Kai-Ming ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Value ◽  
Clinicopathological Characteristics ◽  
Survival Outcome ◽  
Clinicopathological Features ◽  
Histological Type ◽  
Biological Behavior ◽  
Term Survival ◽  
Long Term Survival

MC tended toward worse tumor biological behavior and long-term survival outcome compared to WMDC. Moreover, MC also showed worse clinicopathological features and survival outcome in some selected patients. For these reasons, MC should be deemed as a special histological type of gastric cancer with worse clinicopathological features and survival outcome.

LONG TERM SURVIVAL OUTCOME FOLLOWING RADICAL CYSTECTOMY FOR TCC OF THE BLADDER - COMPARISON BETWEEN PRIMARY AND SALVAGE RADICAL CYSTECTOMY

2009 ◽  
Vol 181 (4) ◽  
pp. 633 ◽  
Author(s):  
Sanjai K Addla ◽  
Purushotham Naidu ◽  
Satish B Maddineni ◽  
Noel W Clarke ◽  
Vijay AC Ramani
Keyword(s):  
Radical Cystectomy ◽  
Survival Outcome ◽  
Term Survival ◽  
Long Term Survival

Actual Long-Term Survival Outcome of 403 Consecutive Patients with Hilar Cholangiocarcinoma

2016 ◽  
Vol 40 (10) ◽  
pp. 2451-2459 ◽  
Author(s):  
Mee Joo Kang ◽  
Jin-Young Jang ◽  
Jihoon Chang ◽  
Yong Chan Shin ◽  
Dooho Lee ◽  
...  
Keyword(s):  
Hilar Cholangiocarcinoma ◽  
Survival Outcome ◽  
Term Survival ◽  
Long Term Survival
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