scholarly journals A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells

2009 ◽  
Vol 107 (1) ◽  
pp. 69-74 ◽  
Author(s):  
K.-H. Lee ◽  
M. Li ◽  
A. M. Michalowski ◽  
X. Zhang ◽  
H. Liao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Embryonic Stem ◽  
Murine Embryonic Stem Cells ◽  
Major Target

scholarly journals Dickkopf Wnt signaling pathway inhibitor 1 regulates the differentiation of mouse embryonic stem cells in vitro and in vivo

2015 ◽  
Vol 13 (1) ◽  
pp. 720-730 ◽  
Author(s):  
LIPING OU ◽  
LIAOQIONG FANG ◽  
HEJING TANG ◽  
HAI QIAO ◽  
XIAOMEI ZHANG ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells

Wnt signaling pathway regulates differentiation of chicken embryonic stem cells into spermatogonial stem cells via Wnt5a

2017 ◽  
Vol 119 (2) ◽  
pp. 1689-1701 ◽  
Author(s):  
Nana He ◽  
Yilin Wang ◽  
Chen Zhang ◽  
Man Wang ◽  
Yingjie Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Embryonic Stem ◽  
Spermatogonial Stem Cells ◽  
Chicken Embryonic Stem Cells

Wnt signaling in biliary development, proliferation, and fibrosis

2021 ◽  
pp. 153537022110613
Author(s):  
Lipeng Tian ◽  
Yichen Wang ◽  
Yoon Young Jang
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Wnt Pathway ◽  
Wnt Signaling Pathway ◽  
Embryonic Stem ◽  
Ductular Reaction ◽  
Ductal Cells ◽  
Underlying Mechanisms

Biliary fibrosis is an important pathological indicator of hepatobiliary damage. Cholangiocyte is the key cell type involved in this process. To reveal the pathogenesis of biliary fibrosis, it is essential to understand the normal development as well as the aberrant generation and proliferation of cholangiocytes. Numerous reports suggest that the Wnt signaling pathway is implicated in the physiological and pathological processes of cholangiocyte development and ductular reaction. In this review, we summarize the effects of Wnt pathway in cholangiocyte development from embryonic stem cells, as well as the underlying mechanisms of cholangiocyte responses to adult ductal damage. Wnt signaling pathway is regulated in a step-wise manner during each of the liver differentiation stages from embryonic stem cells to functional mature cholangiocytes. With the modulation of Wnt pathway, cholangiocytes can also be generated from adult liver progenitor cells and mature hepatocytes to repair liver damage. Non-canonical Wnt signaling is triggered in the active ductal cells during biliary fibrosis. Targeted control of the Wnt signaling may hold the great potential to reduce and/or reverse the biliary fibrogenic process.

scholarly journals The Effects of Small Molecule Inhibitors of Wnt/β-Catenin Signaling Pathway on Murine Embryonic Stem Cells.

2008 ◽  
Vol 78 (Suppl_1) ◽  
pp. 117-117
Author(s):  
Timothy McKinnon ◽  
Hong Ma ◽  
Michael Kahn
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Signaling Pathway ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Embryonic Stem ◽  
Murine Embryonic Stem Cells

scholarly journals ER71 specifies Flk-1+ hemangiogenic mesoderm by inhibiting cardiac mesoderm and Wnt signaling

Blood ◽  
2012 ◽  
Vol 119 (14) ◽  
pp. 3295-3305 ◽  
Author(s):  
Fang Liu ◽  
Inyoung Kang ◽  
Changwon Park ◽  
Li-Wei Chang ◽  
Wei Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Endothelial Cell ◽  
Embryonic Stem Cells ◽  
Wnt Signaling ◽  
Wnt Signaling Pathway ◽  
Embryonic Stem ◽  
Cell Lineage ◽  
Mesoderm Specification ◽  
In The Wild ◽  
Ets Transcription Factor

Abstract Two distinct types of Flk-1+ mesoderm, hemangiogenic and cardiogenic, are thought to contribute to blood, vessel, and cardiac cell lineages. However, our understanding of how Flk-1+ mesoderm is specified is currently limited. In the present study, we investigated whether ER71, an Ets transcription factor essential for hematopoietic and endothelial cell lineage development, could modulate the hemangiogenic or cardiogenic outcome of the Flk-1+ mesoderm. We show that Flk-1+ mesoderm can be divided into Flk-1+PDGFRα− hemangiogenic and Flk-1+PDGFRα+ cardiogenic mesoderm. ER71-deficient embryonic stem cells produced only the Flk-1+PDGFRα+ cardiogenic mesoderm, which generated SMCs and cardiomyocytes. Enforced ER71 expression in the wild-type embryonic stem cells skewed toward the Flk-1+PDGFRα− mesoderm formation, which generated hematopoietic and endothelial cells. Whereas hematopoietic and endothelial cell genes were positively regulated by ER71, cardiac and Wnt signaling pathway genes were negatively regulated by ER71. We show that ER71 could inhibit Wnt signaling in VE-cadherin–independent as well as VE-cadherin–dependent VE-cadherin/β-catenin/Flk-1 complex formation. Enforced β-catenin could rescue cardiogenic mesoderm in the context of ER71 overexpression. In contrast, ER71-deficient Flk-1+ mesoderm displayed enhanced Wnt signaling, which was reduced by ER71 re-introduction. We provide the molecular basis for the antagonistic relationship between hemangiogenic and cardiogenic mesoderm specification by ER71 and Wnt signaling.

Microcephaly and Effects of Cdk5rap2 Downregulation in Murine Embryonic Stem Cells

2012 ◽  
Vol 43 (02) ◽  
Author(s):  
N Krämer ◽  
L Issa ◽  
G Neubert ◽  
A Seiler ◽  
O Ninnemann ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Murine Embryonic Stem Cells
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