scholarly journals Retinoic Acid Suppresses the Canonical Wnt Signaling Pathway in Embryonic Stem Cells and Activates the Noncanonical Wnt Signaling Pathway

Stem Cells ◽  
2014 ◽  
Vol 32 (8) ◽  
pp. 2061-2071 ◽  
Author(s):  
Kwame Osei-Sarfo ◽  
Lorraine J. Gudas
Keyword(s):  
Stem Cells ◽  
Retinoic Acid ◽  
Embryonic Stem Cells ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Embryonic Stem ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt

scholarly journals Dickkopf Wnt signaling pathway inhibitor 1 regulates the differentiation of mouse embryonic stem cells in vitro and in vivo

2015 ◽  
Vol 13 (1) ◽  
pp. 720-730 ◽  
Author(s):  
LIPING OU ◽  
LIAOQIONG FANG ◽  
HEJING TANG ◽  
HAI QIAO ◽  
XIAOMEI ZHANG ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells

scholarly journals Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells

Stem Cells ◽  
2019 ◽  
Vol 38 (3) ◽  
pp. 352-368 ◽  
Author(s):  
Wenbin Liang ◽  
Pengcheng Han ◽  
Elizabeth H. Kim ◽  
Jordan Mak ◽  
Rui Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Wnt Signaling ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Pacemaker Cell ◽  
Canonical Wnt Signaling ◽  
Cell Specification ◽  
Canonical Wnt

scholarly journals Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells

Blood ◽  
2008 ◽  
Vol 111 (1) ◽  
pp. 122-131 ◽  
Author(s):  
Petter S. Woll ◽  
Julie K. Morris ◽  
Matt S. Painschab ◽  
Rebecca K. Marcus ◽  
Aimee D. Kohn ◽  
...  
Keyword(s):  
Stem Cells ◽  
Endothelial Cells ◽  
Embryonic Stem Cells ◽  
Wnt Signaling ◽  
Human Embryonic Stem Cells ◽  
Stromal Cells ◽  
Hematopoietic Cells ◽  
Embryonic Stem ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt

Human embryonic stem cells (hESCs) provide an important means to effectively study soluble and cell-bound mediators that regulate development of early blood and endothelial cells in a human model system. Here, several complementary methods are used to demonstrate canonical Wnt signaling is important for development of hESC-derived cells with both hematopoietic and endothelial potential. Analyses using both standard flow cy-tometry, as well the more detailed high-throughput image scanning flow cytometry, characterizes sequential development of distinct early developing CD34brightCD31+Flk1+ cells and a later population of CD34dimCD45+ cells. While the CD34brightCD31+Flk1+ have a more complex morphology and can develop into both endothelial cells and hematopoietic cells, the CD34dimCD45+ cells have a simpler morphology and give rise to only hematopoietic cells. Treatment with dickkopf1 to inhibit Wnt signaling results in a dramatic decrease in development of cells with hematoendothelial potential. In addition, activation of the canonical Wnt signaling pathway in hESCs by coculture with stromal cells that express Wnt1, but not use of noncanonical Wnt5-expressing stromal cells, results in an accelerated differentiation and higher percentage of CD34brightCD31+Flk1+ cells at earlier stages of differentiation. These studies effectively demonstrate the importance of canonical Wnt signaling to mediate development of early hematoendothelial progenitors during human development.

scholarly journals A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells

2009 ◽  
Vol 107 (1) ◽  
pp. 69-74 ◽  
Author(s):  
K.-H. Lee ◽  
M. Li ◽  
A. M. Michalowski ◽  
X. Zhang ◽  
H. Liao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Embryonic Stem ◽  
Murine Embryonic Stem Cells ◽  
Major Target

scholarly journals Canonical Wnt Signaling Induces a Primitive Endoderm Metastable State in Mouse Embryonic Stem Cells

Stem Cells ◽  
2013 ◽  
Vol 31 (4) ◽  
pp. 752-764 ◽  
Author(s):  
Feodor D. Price ◽  
Hang Yin ◽  
Andrew Jones ◽  
Wilfred van Ijcken ◽  
Frank Grosveld ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Wnt Signaling ◽  
Metastable State ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Primitive Endoderm ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt

Canonical Wnt signaling pathway contributes to the proliferation and survival in porcine pancreatic stem cells (PSCs)

2015 ◽  
Vol 362 (2) ◽  
pp. 379-388 ◽  
Author(s):  
Xin He ◽  
Wei Han ◽  
Shu-xian Hu ◽  
Ming-zhi Zhang ◽  
Jin-lian Hua ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Canonical Wnt Signaling ◽  
Pancreatic Stem Cells ◽  
Canonical Wnt

Wnt signaling pathway regulates differentiation of chicken embryonic stem cells into spermatogonial stem cells via Wnt5a

2017 ◽  
Vol 119 (2) ◽  
pp. 1689-1701 ◽  
Author(s):  
Nana He ◽  
Yilin Wang ◽  
Chen Zhang ◽  
Man Wang ◽  
Yingjie Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Embryonic Stem ◽  
Spermatogonial Stem Cells ◽  
Chicken Embryonic Stem Cells
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