scholarly journals Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species

2019 ◽  
Vol 116 (49) ◽  
pp. 24760-24769 ◽  
Author(s):  
John W. Bostick ◽  
Yetao Wang ◽  
Zeli Shen ◽  
Yong Ge ◽  
Jeffrey Brown ◽  
...  
Keyword(s):  
Protective Immunity ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Proliferative Capacity ◽  
Microbe Interactions ◽  
Group 3 ◽  
Host Microbe Interactions ◽  
Immunocompromised Mice ◽  
Opposing Effects

Intestinal innate lymphoid cells (ILCs) contribute to the protective immunity and homeostasis of the gut, and the microbiota are critically involved in shaping ILC function. However, the role of the gut microbiota in regulating ILC development and maintenance still remains elusive. Here, we identified opposing effects on ILCs by two Helicobacter species, Helicobacter apodemus and Helicobacter typhlonius, isolated from immunocompromised mice. We demonstrated that the introduction of both Helicobacter species activated ILCs and induced gut inflammation; however, these Helicobacter species negatively regulated RORγt+ group 3 ILCs (ILC3s), especially T-bet+ ILC3s, and diminished their proliferative capacity. Thus, these findings underscore a previously unknown dichotomous regulation of ILC3s by Helicobacter species, and may serve as a model for further investigations to elucidate the host–microbe interactions that critically sustain the maintenance of intestinal ILC3s.

scholarly journals A circadian clock is essential for homeostasis of group 3 innate lymphoid cells in the gut

2019 ◽  
Vol 4 (40) ◽  
pp. eaax1215 ◽  
Author(s):  
Fei Teng ◽  
Jeremy Goc ◽  
Lei Zhou ◽  
Coco Chu ◽  
Manish A. Shah ◽  
...  
Keyword(s):  
Circadian Clock ◽  
Target Genes ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Expression Of Genes ◽  
Microbe Interactions ◽  
Inflammatory Bowel ◽  
Group 3 ◽  
Host Microbe Interactions ◽  
Specific Deletion

Group 3 innate lymphoid cells (ILC3s) critically orchestrate host-microbe interactions in the healthy mammalian intestine and become substantially impaired in the context of inflammatory bowel disease (IBD). However, the molecular pathways controlling the homeostasis of ILC3s remain incompletely defined. Here, we identify that intestinal ILC3s are highly enriched in expression of genes involved in the circadian clock and exhibit diurnal oscillations of these pathways in response to light cues. Classical ILC3 effector functions also exhibited diurnal oscillations, and lineage-specific deletion of BMAL1, a master regulator of the circadian clock, resulted in markedly reduced ILC3s selectively in the intestine. BMAL1-deficient ILC3s exhibit impaired expression of Nr1d1 and Per3, hyperactivation of RORγt-dependent target genes, and elevated proapoptotic pathways. Depletion of the microbiota with antibiotics partially reduced the hyperactivation of BMAL1-deficient ILC3s and restored cellular homeostasis in the intestine. Last, ILC3s isolated from the inflamed intestine of patients with IBD exhibit substantial alterations in expression of several circadian-related genes. Our results collectively define that circadian regulation is essential for the homeostasis of ILC3s in the presence of a complex intestinal microbiota and that this pathway is disrupted in the context of IBD.

scholarly journals T-Bet Controls Cellularity of Intestinal Group 3 Innate Lymphoid Cells

2021 ◽  
Vol 11 ◽  
Author(s):  
Jan-Hendrik Schroeder ◽  
Katrin Meissl ◽  
Dominika Hromadová ◽  
Jonathan W. Lo ◽  
Joana F. Neves ◽  
...  
Keyword(s):  
Critical Factor ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Mucosal Surfaces ◽  
Specific Pathogen ◽  
Enhanced Expression ◽  
Group 3 ◽  
Deficient Mice

Innate lymphoid cells (ILC) play a significant immunological role at mucosal surfaces such as the intestine. T-bet-expressing group 1 innate lymphoid cells (ILC1) are believed to play a substantial role in inflammatory bowel disease (IBD). However, a role of T-bet-negative ILC3 in driving colitis has also been suggested in mouse models questioning T-bet as a critical factor for IBD. We report here that T-bet deficient mice had a greater cellularity of NKp46-negative ILC3 correlating with enhanced expression of RORγt and IL-7R, but independent of signaling through STAT1 or STAT4. We observed enhanced neutrophilia in the colonic lamina propria (cLP) of these animals, however, we did not detect a greater risk of T-bet-deficient mice to develop spontaneous colitis. Furthermore, by utilizing an in vivo fate-mapping approach, we identified a population of T-bet-positive precursors in NKp46-negative ILC3s. These data suggest that T-bet controls ILC3 cellularity, but does do not drive a pathogenic role of ILC3 in mice with a conventional specific pathogen-free microbiota.

Role of group 3 innate lymphoid cells during experimental otitis media in a rat model

2016 ◽  
Vol 88 ◽  
pp. 146-152 ◽  
Author(s):  
Chang Gun Cho ◽  
Sung Ho Gong ◽  
Hee-Bok Kim ◽  
Jae-Jun Song ◽  
Joo Hyun Park ◽  
...  
Keyword(s):  
Otitis Media ◽  
Rat Model ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Group 3

scholarly journals Therapeutic Potential of Innate Lymphoid Cells for Multiple Myeloma Therapy

Cancers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 4806
Author(s):  
Aneta Szudy-Szczyrek ◽  
Sean Ahern ◽  
Magdalena Kozioł ◽  
Daria Majowicz ◽  
Michał Szczyrek ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Therapeutic Potential ◽  
Antitumour Activity ◽  
Specific Antigen ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Innate lymphoid cells (ILCs) are a recently identified family of lymphocyte-like cells lacking a specific antigen receptor. They are part of the innate immune system. They play a key role in tissue homeostasis and also control inflammatory and neoplastic processes. In response to environmental stimuli, ILCs change their phenotype and functions, and influence the activity of other cells in the microenvironment. ILC dysfunction can lead to a wide variety of diseases, including cancer. ILC can be divided into three subgroups: ILC Group 1, comprising NK cells and ILC1; Group 2, including ILC2 alone; and Group 3, containing Lymphoid Tissue inducers (LTi) and ILC3 cells. While Group 1 ILCs mainly exert antitumour activity, Group 2 and Group 3 ILCs are protumorigenic in nature. A growing body of preclinical and clinical data support the role of ILCs in the pathogenesis of multiple myeloma (MM). Therefore, targeting ILCs may be of clinical benefit. In this manuscript, we review the available data on the role of ILCs in MM immunology and therapy.

scholarly journals Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis

Nature ◽  
2019 ◽  
Vol 570 (7762) ◽  
pp. 528-532 ◽  
Author(s):  
Amanda Ardain ◽  
Racquel Domingo-Gonzalez ◽  
Shibali Das ◽  
Samuel W. Kazer ◽  
Nicole C. Howard ◽  
...  
Keyword(s):  
Protective Immunity ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Group 3

scholarly journals Publisher Correction: Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis

Nature ◽  
2019 ◽  
Vol 572 (7768) ◽  
pp. E10-E10
Author(s):  
Amanda Ardain ◽  
Racquel Domingo-Gonzalez ◽  
Shibali Das ◽  
Samuel W. Kazer ◽  
Nicole C. Howard ◽  
...  
Keyword(s):  
Protective Immunity ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Group 3

scholarly journals Expanded IL-22+ Group 3 Innate Lymphoid Cells and Role of Oxidized LDL-C in the Pathogenesis of Axial Spondyloarthritis with Dyslipidaemia

2021 ◽  
Vol 21 (6) ◽  
Author(s):  
Hong Ki Min ◽  
Jeonghyeon Moon ◽  
Seon-Yeong Lee ◽  
A Ram Lee ◽  
Chae Rim Lee ◽  
...  
Keyword(s):  
Axial Spondyloarthritis ◽  
Oxidized Ldl ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Group 3
Sign in / Sign up

Export Citation Format

Share Document