scholarly journals Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression

2001 ◽  
Vol 98 (20) ◽  
pp. 11563-11568 ◽  
Author(s):  
B. Kwabi-Addo ◽  
D. Giri ◽  
K. Schmidt ◽  
K. Podsypanina ◽  
R. Parsons ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Cancer Progression ◽  
Suppressor Gene ◽  
Prostate Cancer Progression

scholarly journals Circulating Cell-Free DNA-Based Detection of Tumor Suppressor Gene Copy Number Loss and Its Clinical Implication in Metastatic Prostate Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Xiaoxi Dong ◽  
Tiantian Zheng ◽  
Minhua Zhang ◽  
Chao Dai ◽  
Lili Wang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Cancer Progression ◽  
Liquid Biopsy ◽  
Copy Number ◽  
Metastatic Prostate Cancer ◽  
Suppressor Gene ◽  
Gene Copy ◽  
Copy Number Loss

Current liquid biopsy assays lack sufficient sensitivity to detect copy number loss, which limits the interrogation of critical tumor suppressor gene deletions during cancer progression and treatment. Here we describe a liquid biopsy assay with improved sensitivity for detection of copy number loss in blood samples with low levels of circulating tumor DNA, and demonstrate its utility by profiling PTEN, RB1, and TP53 genetic loss in metastatic prostate cancer patients.

The MXI1 tumor suppressor gene is not mutated in primary prostate cancer.

1998 ◽  
Author(s):  
M A Kuczyk ◽  
J Serth ◽  
C Bokemeyer ◽  
J Schwede ◽  
R Herrmann ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Primary Prostate Cancer
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