The Role of hCDC4 as a Tumor Suppressor Gene in Genomic Instability Underlying Prostate Cancer

2006 ◽  
Author(s):  
Audrey Van Drogen ◽  
Charles H. Spruck
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Genomic Instability ◽  
Suppressor Gene

The role of tumor suppressor gene SOX11 in prostate cancer

Tumor Biology ◽  
2015 ◽  
Vol 36 (8) ◽  
pp. 6133-6138 ◽  
Author(s):  
Zhiyong Yao ◽  
Bin Sun ◽  
Quan Hong ◽  
Jingmin Yan ◽  
Dawei Mu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene

979 PREVALENCE AND PROGNOSTIC ROLE OF COMMON TUMOR SUPPRESSOR GENE DELETIONS IN PROSTATE CANCER

2013 ◽  
Vol 189 (4S) ◽  
Author(s):  
Thorsten Schlomm ◽  
Martinia Kluth ◽  
Pierre Tennstedt ◽  
Guido Sauter ◽  
Lia Burkhardt ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Prognostic Role ◽  
Gene Deletions

The role of the p53 tumor suppressor gene in prostate cancer: A possible biomarker?

Urology ◽  
1996 ◽  
Vol 48 (6) ◽  
pp. 971-979 ◽  
Author(s):  
Howard B. Heidenberg ◽  
John J. Bauer ◽  
David G. McLeod ◽  
Judd W. Moul ◽  
Shiv Srivastava
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
P53 Tumor Suppressor ◽  
P53 Tumor Suppressor Gene

scholarly journals KLF2 Inhibits the Migration and Invasion of Prostate Cancer Cells by Downregulating MMP2

2018 ◽  
Vol 13 (1) ◽  
pp. 155798831881690 ◽  
Author(s):  
Binshuai Wang ◽  
Mingyuan Liu ◽  
Yimeng Song ◽  
Changying Li ◽  
Shudong Zhang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Cell Function ◽  
Malignant Tumors ◽  
Suppressor Gene ◽  
Migration And Invasion ◽  
Tissue Samples ◽  
Tumor Tissues ◽  
Luciferase Activity Assay

KLF2, a member of the Kruppel-like factor (KLF) family, is thought to be a tumor suppressor in many kinds of malignant tumors. Its functions in prostate cancer (PCa) are unknown. This study aimed to explore the role of KLF2 in the migration and invasion of PCa cells. The expression of KLF2 was measured by immunohistochemistry in PCa tissues and in paired non-tumor tissues. KLF2 and MMP2 expression in cells was measured by Western blot and RT-qPCR. Adenoviruses and siRNAs were used in cell function tests to investigate the role of KLF2 in regulating MMP2. Interactions between KLF2 and MMP2 were analyzed by a luciferase activity assay. The present study, for the first time, identified that KLF2 was downregulated both in PCa clinical tissue samples and in cancer cell lines. The overexpression of KLF2 inhibited the migration and invasion of PCa cells via the suppression of MMP2.This study demonstrates that KLF2 might act as a tumor suppressor gene in PCa and that the pharmaceutical upregulation of KLF2 may be a potential approach for treatment.

The MXI1 tumor suppressor gene is not mutated in primary prostate cancer.

1998 ◽  
Author(s):  
M A Kuczyk ◽  
J Serth ◽  
C Bokemeyer ◽  
J Schwede ◽  
R Herrmann ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Primary Prostate Cancer
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