Multiplexed sensing of biomolecules with optically detected magnetic resonance of nitrogen-vacancy centers in diamond

2021 ◽  
Vol 118 (51) ◽  
pp. e2112664118
Author(s):  
Metin Kayci ◽  
Jilin Fan ◽  
Onur Bakirman ◽  
Andreas Herrmann
Keyword(s):  
Limit Of Detection ◽  
Medical Diagnostics ◽  
Nitrogen Vacancy ◽  
Great Effort ◽  
Practical Applications ◽  
Dna Assay ◽  
Single Base Mismatch ◽  
Wide Range ◽  
Nitrogen Vacancy Centers ◽  
Optically Detected

In the past decade, a great effort has been devoted to develop new biosensor platforms for the detection of a wide range of analytes. Among the various approaches, magneto-DNA assay platforms have received extended interest for high sensitive and specific detection of targets with a simultaneous manipulation capacity. Here, using nitrogen-vacancy quantum centers in diamond as transducers for magnetic nanotags (MNTs), a hydrogel-based, multiplexed magneto-DNA assay is presented. Near–background-free sensing with diamond-based imaging combined with noninvasive control of chemically robust nanotags renders it a promising platform for applications in medical diagnostics, life science, and pharmaceutical drug research. To demonstrate its potential for practical applications, we employed the sensor platform in the sandwich DNA hybridization process and achieved a limit of detection in the attomolar range with single-base mismatch differentiation.

scholarly journals Optically detected nuclear quadrupolar interaction ofN14in nitrogen-vacancy centers in diamond

2014 ◽  
Vol 89 (20) ◽  
Author(s):  
Chang S. Shin ◽  
Mark C. Butler ◽  
Hai-Jing Wang ◽  
Claudia E. Avalos ◽  
Scott J. Seltzer ◽  
...  
Keyword(s):  
Nitrogen Vacancy ◽  
Quadrupolar Interaction ◽  
Nitrogen Vacancy Centers ◽  
Optically Detected

MoSx–Co3O4 Nanocomposite for Selective Determination of Ascorbic Acid

2021 ◽  
Vol 21 (4) ◽  
pp. 2595-2603
Author(s):  
Sidra Amin ◽  
Aneela Tahira ◽  
Amber Solangi ◽  
Ayman Nafady ◽  
Zafar Hussain Ibupoto
Keyword(s):  
Ascorbic Acid ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Limit Of Detection ◽  
Active Surface Area ◽  
Carbon Electrode ◽  
Selective Determination ◽  
Practical Applications ◽  
Wide Range

Designing a nanocomposite with sensitive and selective determination of ascorbic acid is challenging task. It is possible through the exploitation of attractive features of nanoscience and nanotechnology for the synthesis of nanostructured materials. Herein, we report the decoration of nanoparticle of MoSx on the surface of Co3O4 nanowires by hydrothermal method. The MoSx nanoparticles shared the large surface on the Co3O4 nanowires, thus it supported in the development enzyme free ascorbic acid sensor. Non-enzymatic sensor based on MoSx-Co3O4 composite was found very selective for the determination of ascorbic acid (AA) in phosphate buffer solution of pH 7.4. The MoSx-Co3O4 nanocomposite was used to modify the glassy carbon electrode to measure AA from variety of practical samples. The MoSx-Co3O4 nanocomposite was used to modify the glassy carbon electrode and it has shown the attractive analytical features such as a low working potential +0.3 V, linear range of concentration from 100–7000 μM, low limit of detection 14 μM, and low limit of quantification (LOQ) of 42 μM. The developed sensor is highly selective and stable. Importantly, it was applied successfully for the practical applications such as detection of AA from grapefruit, tomato and lemon juice. The excellent electrochemical properties of fabricated MoSx-Co3O4 nanocomposite can be attributed to the increasing electro active surface area of MoSx. The presented nanocomposite is earth abundant, environment friendly and inexpensive and it holds promising features for the selective and sensitive determination of AA from practical applications. The nanocomposite can be capitalized into the wide range of biomedical applications.

scholarly journals Broadband, large-area microwave antenna for optically detected magnetic resonance of nitrogen-vacancy centers in diamond

2016 ◽  
Vol 87 (5) ◽  
pp. 053904 ◽  
Author(s):  
Kento Sasaki ◽  
Yasuaki Monnai ◽  
Soya Saijo ◽  
Ryushiro Fujita ◽  
Hideyuki Watanabe ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Nitrogen Vacancy ◽  
Microwave Antenna ◽  
Large Area ◽  
Optically Detected Magnetic Resonance ◽  
Nitrogen Vacancy Centers ◽  
Optically Detected
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