scholarly journals Secretion of a soluble, chimeric gamma delta T-cell receptor-immunoglobulin heterodimer.

1992 ◽  
Vol 89 (15) ◽  
pp. 6871-6875 ◽  
Author(s):  
D. Eilat ◽  
G. E. Kikuchi ◽  
J. E. Coligan ◽  
E. M. Shevach
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Gamma Delta ◽  
Gamma Delta T Cell

scholarly journals Amino acid substitutions in the floor of the putative antigen-binding site of H-2T22 affect recognition by a gamma delta T-cell receptor

1993 ◽  
Vol 90 (23) ◽  
pp. 11396-11400 ◽  
Author(s):  
S Moriwaki ◽  
B S Korn ◽  
Y Ichikawa ◽  
L van Kaer ◽  
S Tonegawa
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Peptide Transporter ◽  
Affect Recognition ◽  
Antigen Binding ◽  
In Vitro Mutagenesis ◽  
Gamma Delta ◽  
T Cell Clone ◽  
Gamma Delta T Cell

We have previously identified a self-reactive gamma delta T-cell clone (KN6) specific for the H-2T region gene product T22b. Now we have investigated by an in vitro mutagenesis analysis of the T22b gene the possibility that the interaction between the KN6 gamma delta T-cell receptor and T22b involves a peptide. The results demonstrate that mutations at the floor of the putative antigen-binding groove of T22b affect recognition by the gamma delta T-cell receptor. Furthermore, we have shown that KN6 cells react with cells that are deficient in the class I peptide transporter TAP1/TAP2. These results suggest that peptide is involved in the interaction of the KN6 T-cell receptor with T22 and that loading of T22 with the putative peptide is TAP1/TAP2-independent.

scholarly journals Gamma/delta lineage relationship within a consecutive series of human precursor T-cell neoplasms

Blood ◽  
1989 ◽  
Vol 74 (7) ◽  
pp. 2508-2518 ◽  
Author(s):  
JP de Villartay ◽  
AB Pullman ◽  
R Andrade ◽  
E Tschachler ◽  
O Colamenici ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Consecutive Series ◽  
Gene Rearrangements ◽  
Gamma Delta ◽  
Delta Gene ◽  
Gene Usage ◽  
Rearrangement Process ◽  
Gamma Delta T Cell

Abstract We analyzed the gene rearrangements associated with the newly described delta T-cell receptor (TCR) gene from a series of 19 consecutive precursor T-cell (lymphoblastic) neoplasms that represent discrete stages surrounding the TCR gene rearrangement process. Significantly, the delta TCR gene showed rearrangement in most (13 of 19) of these T cells, and in addition it was rearranged in two cells displaying no rearrangement for any other TCR gene. Our survey showed three types of delta gene rearrangements associated with cell-surface TCR expression that presumably represent usage of three V delta genes. This analysis demonstrates (1) a major subclass of human precursor T-cell neoplasms belonging to the gamma/delta T-cell receptor-rearranging subtype; (2) a narrow repertoire of human V delta gene usage; and (3) the utility of delta gene rearrangements as a diagnostic clonal marker in precursor T lymphoblastic neoplasms.

Identification of a T3-associated gamma delta T cell receptor on Thy-1+ dendritic epidermal Cell lines

Science ◽  
1987 ◽  
Vol 236 (4803) ◽  
pp. 834-837 ◽  
Author(s):  
F Koning ◽  
G Stingl ◽  
W. Yokoyama ◽  
H Yamada ◽  
W. Maloy ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Lines ◽  
Epidermal Cell ◽  
Cell Receptor ◽  
Gamma Delta ◽  
Gamma Delta T Cell

scholarly journals Novel primary thymic defect with T lymphocytes expressing gamma delta T cell receptor.

1989 ◽  
Vol 42 (7) ◽  
pp. 705-711 ◽  
Author(s):  
C Geisler ◽  
G Pallesen ◽  
P Platz ◽  
N Odum ◽  
E Dickmeiss ◽  
...  
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Gamma Delta ◽  
Gamma Delta T Cell

Immunohistochemical characterization, distribution and ultrastructure of lymphocytes bearing the gamma/delta T-cell receptor in the human gut

1991 ◽  
Vol 60 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Kouhei Fukushima ◽  
Takayuki Masuda ◽  
Haruo Ohtani ◽  
Iwao Sasaki ◽  
Yuji Funayama ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Gamma Delta ◽  
Human Gut ◽  
Gamma Delta T Cell

scholarly journals gamma/delta T cell-deficient mice have impaired mucosal immunoglobulin A responses.

1996 ◽  
Vol 183 (4) ◽  
pp. 1929-1935 ◽  
Author(s):  
K Fujihashi ◽  
J R McGhee ◽  
M N Kweon ◽  
M D Cooper ◽  
S Tonegawa ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cholera Toxin ◽  
T Cell Receptor ◽  
Tetanus Toxoid ◽  
Plasma Cells ◽  
Cell Receptor ◽  
Gamma Delta ◽  
Igg Antibody ◽  
Gamma Delta T Cell

Mucosal tissues of mice are enriched in T cells that express the gamma/delta T cell receptor. Since the function of these cells remains unclear, we have compared mucosal immune responses in gamma/delta T cell receptor-deficient (TCRdelta-/-) mice versus control mice of the same genetic background. The frequency of intestinal immunoglobulin (Ig) A plasma cells as well as IgA levels in serum, bile, saliva, and fecal samples were markedly reduced in TCRdelta-/- mice. The TCRdelta-/- mice produced much lower levels of IgA antibodies when immunized orally with a vaccine of tetanus toxoid plus cholera toxin as adjuvant. Conversely, the antigen-specific IgM and IgG antibody responses were comparable to orally immunized control mice. Direct assessment of the cells forming antibodies against the tetanus toxoid and cholera toxin antigens indicated that significantly lower numbers of IgA antibody-producing cells were present in the intestinal lamina propria and Peyer's patches of TCRdelta-/- mice compared with the orally immunized control mice. The selective reduction of IgA responses to ingested antigens in the absence of gamma/delta T cells suggests a specialized role for gamma/delta cells in mucosal immunity.

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