scholarly journals Chronic growth stimulation of human adult melanocytes by inflammatory mediators in vitro: implications for nevus formation and initial steps in melanocyte oncogenesis.

1993 ◽  
Vol 90 (5) ◽  
pp. 1790-1794 ◽  
Author(s):  
E. E. Medrano ◽  
J. Z. Farooqui ◽  
R. E. Boissy ◽  
Y. L. Boissy ◽  
B. Akadiri ◽  
...  
1999 ◽  
Vol 46 (4) ◽  
pp. 513-520 ◽  
Author(s):  
SATOSHI MARUYAMA ◽  
NARIAKI FUJIMOTO ◽  
HONG YIN ◽  
AKIHIRO ITO

1995 ◽  
Vol 121 (2) ◽  
pp. 76-78 ◽  
Author(s):  
Nobuaki Kikyo ◽  
Koichi Hagiwara ◽  
Yoshio Yazaki ◽  
Tetsuro Okabe

Author(s):  
A. B. Gorbunov ◽  
T. V. Kurlovich ◽  
T. I. Snakina ◽  
T. A. Nedovesova

Creation of allotetraploid cowberry-blueberry hybrids is a promising direction in Vacciniaceae breeding. However, obtaining such hybrids is difficult because of biological features of tetraploid cowberry. In this regard the aim of research was study of pollen viability of tetraploid cowberry, its crossing ability with different species and interspesific blueberry hybrid in various years, as well as based on the results obtained, selection of promising methods of growth stimulation of pollen tubes, hybrid seed setting and cultivation of hybrid seedlings.As a result of research it has been established that tetraploid cowberry is characterized by low productivity and pollen viability, although its viability may reach 10.7 % in some years. Hybrid seedlings gradually died off with growth. On the base of the data obtained it is proposed that a special technique be used to increase hybrid fruit setting (pollination of flowers by a mixture of pollen, pollination in different life spans of a flower, castration of flowers without removing a corolla, reciprocal crosses, spraying pollinated flowers by solutions of growth regulators and microelements) and cultivation of hybrid seedlings (in vitro culture).


2021 ◽  
Vol 12 ◽  
Author(s):  
Richard Baguma ◽  
Stanley Kimbung Mbandi ◽  
Miguel J. Rodo ◽  
Mzwandile Erasmus ◽  
Jonathan Day ◽  
...  

The risk of progression from Mycobacterium tuberculosis (M.tb) infection to active tuberculosis (TB) disease varies markedly with age. TB disease is significantly less likely in pre-adolescent children above 4 years of age than in very young children or post-pubescent adolescents and young adults. We hypothesized that pro-inflammatory responses to M.tb in pre-adolescent children are either less pronounced or more regulated, than in young adults. Inflammatory and antimicrobial mediators, measured by microfluidic RT-qPCR and protein bead arrays, or by analyzing published microarray data from TB patients and controls, were compared in pre-adolescent children and adults. Multivariate analysis revealed that M.tb-uninfected 8-year-old children had lower levels of myeloid-associated pro-inflammatory mediators than uninfected 18-year-old young adults. Relative to uninfected children, those with M.tb-infection had higher levels of similar myeloid inflammatory responses. These inflammatory mediators were also expressed after in vitro stimulation of whole blood from uninfected children with live M.tb. Our findings suggest that myeloid inflammation is intrinsically lower in pre-pubescent children than in young adults. The lower or more regulated pro-inflammatory responses may play a role in the lower risk of TB disease in this age group.


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