scholarly journals Polyunsaturated Fatty Acids Decrease Expression of Promoters with Sterol Regulatory Elements by Decreasing Levels of Mature Sterol Regulatory Element-binding Protein

1998 ◽  
Vol 273 (40) ◽  
pp. 25537-25540 ◽  
Author(s):  
Tilla S. Worgall ◽  
Stephen L. Sturley ◽  
Toru Seo ◽  
Timothy F. Osborne ◽  
Richard J. Deckelbaum
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Binding Protein ◽  
Regulatory Element ◽  
Regulatory Elements ◽  
Element Binding Protein ◽  
Sterol Regulatory Element

scholarly journals Effects of fatty acids on gene expression: role of peroxisome proliferator-activated receptor α, liver X receptor α and sterol regulatory element-binding protein-1c

2002 ◽  
Vol 61 (3) ◽  
pp. 371-374 ◽  
Author(s):  
Sander Kersten
Keyword(s):  
Fatty Acids ◽  
Binding Protein ◽  
Regulatory Element ◽  
Liver X Receptor ◽  
Dietary Fatty Acids ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Liver X Receptor Α ◽  
Element Binding Protein ◽  
Sterol Regulatory Element

Dietary fatty acids have numerous effects on cellular function, many of which are achieved by altering the expression of genes. The present paper reviews recent data on the mechanisms by which fatty acids influence DNA transcription, and focus specifically on the importance of three transcription factors: peroxisome proliferator-activated receptor α; liver X receptor α; sterol regulatory element-binding protein 1c. These data indicate that fatty acids induce or inhibit the mRNA expression of a variety of different genes by acting both as agonists and as antagonists for nuclear hormone receptors.

scholarly journals Sterol Regulatory Element Binding Protein Is a Principal Regulator of Anaerobic Gene Expression in Fission Yeast

2006 ◽  
Vol 26 (7) ◽  
pp. 2817-2831 ◽  
Author(s):  
Bridget L. Todd ◽  
Emerson V. Stewart ◽  
John S. Burg ◽  
Adam L. Hughes ◽  
Peter J. Espenshade
Keyword(s):  
Gene Expression ◽  
Fission Yeast ◽  
Binding Protein ◽  
Regulatory Element ◽  
Regulatory Elements ◽  
Gene Promoters ◽  
Anaerobic Conditions ◽  
Indirect Measure ◽  
Element Binding Protein ◽  
Sterol Regulatory Element

ABSTRACT Fission yeast sterol regulatory element binding protein (SREBP), called Sre1p, functions in an oxygen-sensing pathway to allow adaptation to fluctuating oxygen concentrations. The Sre1p-Scp1p complex responds to oxygen-dependent sterol synthesis as an indirect measure of oxygen availability. To examine the role of Sre1p in anaerobic gene expression in Schizosaccharomyces pombe, we performed transcriptional profiling experiments after a shift to anaerobic conditions for 1.5 h. Of the 4,940 genes analyzed, expression levels of 521 (10.5%) and 686 (13.9%) genes were significantly increased and decreased, respectively, under anaerobic conditions. Sre1p controlled 68% of genes induced ≥2-fold. Oxygen-requiring biosynthetic pathways for ergosterol, heme, sphingolipid, and ubiquinone were primary targets of Sre1p. Induction of glycolytic genes and repression of mitochondrial oxidative phosphorylation genes largely did not require Sre1p. Using chromatin immunoprecipitation, we demonstrated that Sre1p acts directly at target gene promoters and stimulates its own transcription under anaerobic conditions. sre1 + promoter analysis identified two DNA elements that are both necessary and sufficient for oxygen-dependent, Sre1p-dependent transcription. Interestingly, these elements are homologous to sterol regulatory elements bound by mammalian SREBP, highlighting the evolutionary conservation between Sre1p and SREBP. We conclude that Sre1p is a principal activator of anaerobic gene expression, upregulating genes required for nonrespiratory oxygen consumption.

scholarly journals Polyunsaturated Fatty Acids Suppress HepaticSterol Regulatory Element-binding Protein-1Expression by Accelerating Transcript Decay

2000 ◽  
Vol 276 (13) ◽  
pp. 9800-9807 ◽  
Author(s):  
Jing Xu ◽  
Margarita Teran-Garcia ◽  
Jung H. Y. Park ◽  
Manabu T. Nakamura ◽  
Steven D. Clarke
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Binding Protein ◽  
Regulatory Element ◽  
Element Binding Protein
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