scholarly journals Polyunsaturated Fatty Acids Suppress HepaticSterol Regulatory Element-binding Protein-1Expression by Accelerating Transcript Decay

2000 ◽  
Vol 276 (13) ◽  
pp. 9800-9807 ◽  
Author(s):  
Jing Xu ◽  
Margarita Teran-Garcia ◽  
Jung H. Y. Park ◽  
Manabu T. Nakamura ◽  
Steven D. Clarke
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Binding Protein ◽  
Regulatory Element ◽  
Element Binding Protein

scholarly journals Effects of fatty acids on gene expression: role of peroxisome proliferator-activated receptor α, liver X receptor α and sterol regulatory element-binding protein-1c

2002 ◽  
Vol 61 (3) ◽  
pp. 371-374 ◽  
Author(s):  
Sander Kersten
Keyword(s):  
Fatty Acids ◽  
Binding Protein ◽  
Regulatory Element ◽  
Liver X Receptor ◽  
Dietary Fatty Acids ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Liver X Receptor Α ◽  
Element Binding Protein ◽  
Sterol Regulatory Element

Dietary fatty acids have numerous effects on cellular function, many of which are achieved by altering the expression of genes. The present paper reviews recent data on the mechanisms by which fatty acids influence DNA transcription, and focus specifically on the importance of three transcription factors: peroxisome proliferator-activated receptor α; liver X receptor α; sterol regulatory element-binding protein 1c. These data indicate that fatty acids induce or inhibit the mRNA expression of a variety of different genes by acting both as agonists and as antagonists for nuclear hormone receptors.

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