scholarly journals Nerve Growth Factor-induced Neuronal Differentiation Requires Generation of Rac1-regulated Reactive Oxygen Species

2000 ◽  
Vol 275 (18) ◽  
pp. 13175-13178 ◽  
Author(s):  
Kazumi Suzukawa ◽  
Koichi Miura ◽  
Junji Mitsushita ◽  
James Resau ◽  
Kunitaka Hirose ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Neuronal Differentiation ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Nerve Growth

scholarly journals Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: Possible role of reactive oxygen species

2010 ◽  
Vol 88 (16) ◽  
pp. 3644-3655 ◽  
Author(s):  
Usha Gundimeda ◽  
Thomas H. McNeill ◽  
Jason E. Schiffman ◽  
David R. Hinton ◽  
Rayudu Gopalakrishna
Keyword(s):  
Reactive Oxygen Species ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Green Tea ◽  
Reactive Oxygen ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Oxygen Species ◽  
Nerve Growth

Reactive Oxygen Species Influence Nerve Growth Factor Synthesis in Primary Rat Astrocytes

2008 ◽  
Vol 62 (6) ◽  
pp. 2178-2186 ◽  
Author(s):  
Philippe Naveilhan ◽  
Isabelle Neveu ◽  
Frédéric Jehan ◽  
Christel Baudet ◽  
Didier Wion ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Nerve Growth ◽  
Rat Astrocytes ◽  
Nerve Growth Factor Synthesis

Chemoattractant agents and nerve growth factor stimulate human spermatozoal reactive oxygen species generation

1993 ◽  
Vol 59 (4) ◽  
pp. 869-875 ◽  
Author(s):  
Donald L. Weese ◽  
Michael L. Peaster ◽  
Reynaldo D. Hernandez ◽  
Gary E. Leach ◽  
Pramod M. Lad ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Nerve Growth

Dermatophagoides pteronyssinus 2 regulates nerve growth factor release to induce airway inflammation via a reactive oxygen species-dependent pathway

2011 ◽  
Vol 300 (2) ◽  
pp. L216-L224 ◽  
Author(s):  
Yi-Ling Ye ◽  
Hung-Tsung Wu ◽  
Chiou-Feng Lin ◽  
Chia-Yuan Hsieh ◽  
Jiu-Yao Wang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Airway Inflammation ◽  
Dermatophagoides Pteronyssinus ◽  
Ros Production ◽  
Oxygen Species ◽  
Nerve Growth ◽  
Der P2 ◽  
Dependent Pathway

Group 2 allergen of Dermatophagoides pteronyssinus 2 (Der p2) induces airway inflammation without protease activity, and elevated nerve growth factor (NGF) levels are also found in this inflammation. How the allergen Der p2 regulates NGF release via reactive oxygen species (ROS) to induce inflammation remains unclear. In the present study, intratracheal administration of Der p2 to mice led to inflammatory cell infiltration, mucus gland hyperplasia, and NGF upregulation in the bronchial epithelium, as well as elevated ROS and NGF production in bronchoalveolar lavage fluids. In addition, Der p2 caused fibrocyte accumulation and mild fibrosis. p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) inhibitors inhibited Der p2-induced NGF release in LA4 lung epithelial cells and MLg lung fibroblasts. Pretreatment with an antioxidant, tiron, reduced the Der p2-induced ROS production, NGF expression and release, p38 MAPK or JNK phosphorylation, and airway inflammation. These results suggest that Der p2 allergen-induced airway inflammation and elevated NGF release were through increasing ROS production and a MAPK-dependent pathway. The use of an antioxidant, tiron, may provide a new therapeutic modality for the treatment of allergic asthma.

scholarly journals Suppression of Nerve Growth Factor-induced Neuronal Differentiation of PC12 Cells

1996 ◽  
Vol 271 (51) ◽  
pp. 33018-33025 ◽  
Author(s):  
Hideaki Kamata ◽  
Chihiro Tanaka ◽  
Hitoshi Yagisawa ◽  
Satoshi Matsuda ◽  
Yukiko Gotoh ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Neuronal Differentiation ◽  
Pc12 Cells ◽  
Nerve Growth
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