Rapid Activation of Antioxidant Defenses by Nerve Growth Factor Suppresses Reactive Oxygen Species during Neuronal Apoptosis: Evidence for a Role in Cytochrome c Redistribution

Group 2 allergen of Dermatophagoides pteronyssinus 2 (Der p2) induces airway inflammation without protease activity, and elevated nerve growth factor (NGF) levels are also found in this inflammation. How the allergen Der p2 regulates NGF release via reactive oxygen species (ROS) to induce inflammation remains unclear. In the present study, intratracheal administration of Der p2 to mice led to inflammatory cell infiltration, mucus gland hyperplasia, and NGF upregulation in the bronchial epithelium, as well as elevated ROS and NGF production in bronchoalveolar lavage fluids. In addition, Der p2 caused fibrocyte accumulation and mild fibrosis. p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) inhibitors inhibited Der p2-induced NGF release in LA4 lung epithelial cells and MLg lung fibroblasts. Pretreatment with an antioxidant, tiron, reduced the Der p2-induced ROS production, NGF expression and release, p38 MAPK or JNK phosphorylation, and airway inflammation. These results suggest that Der p2 allergen-induced airway inflammation and elevated NGF release were through increasing ROS production and a MAPK-dependent pathway. The use of an antioxidant, tiron, may provide a new therapeutic modality for the treatment of allergic asthma.

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The caspase-8/Bid/cytochrome c axis links signals from death receptors to mitochondrial reactive oxygen species production

Free Radical Biology and Medicine ◽

10.1016/j.freeradbiomed.2017.09.001 ◽

2017 ◽

Vol 112 ◽

pp. 567-577 ◽

Cited By ~ 17

Author(s):

Wan-Sung Kim ◽

Kwang-Soon Lee ◽

Ji-Hee Kim ◽

Chun-Ki Kim ◽

Gwangsoo Lee ◽

...

Keyword(s):

Reactive Oxygen Species ◽

Cytochrome C ◽

Reactive Oxygen Species Production ◽

Reactive Oxygen ◽

Death Receptors ◽

Caspase 8 ◽

Oxygen Species ◽

Mitochondrial Reactive Oxygen Species ◽

Species Production

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Myrtol improves post‑traumatic knee osteoarthritis by regulation of reactive oxygen species, transforming growth factor β1 and apoptosis in a mouse model

Experimental and Therapeutic Medicine ◽

10.3892/etm.2017.5367 ◽

2017 ◽

Cited By ~ 1

Author(s):

Liqun Duan ◽

Wenzhi Zhang ◽

Feng Zhang ◽

Haiping Cai

Keyword(s):

Reactive Oxygen Species ◽

Growth Factor ◽

Mouse Model ◽

Knee Osteoarthritis ◽

Transforming Growth Factor ◽

Reactive Oxygen ◽

Transforming Growth Factor Β1 ◽

Oxygen Species ◽

Post Traumatic

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Exploring the Potentials of Antioxidants in Retarding Ageing

Examining the Development, Regulation, and Consumption of Functional Foods - Advances in Environmental Engineering and Green Technologies ◽

10.4018/978-1-5225-0607-2.ch008 ◽

2017 ◽

pp. 166-195 ◽

Cited By ~ 1

Author(s):

Minu Kesheri ◽

Swarna Kanchan ◽

Rajeshwar P. Sinha

Keyword(s):

Oxidative Stress ◽

Reactive Oxygen Species ◽

Growth And Development ◽

Aging Process ◽

Reactive Oxygen ◽

Normal Growth ◽

Antioxidant Defenses ◽

Oxygen Species ◽

Biotic Stresses ◽

Living Organisms

In retrospect to the rise in the occurrence of ageing related disorders and the everlasting desire to overcome ageing, exploring the causes, mechanisms and therapies to curb ageing becomes relevant. Reactive Oxygen Species (ROS) are commonly generated during normal growth and development. However abiotic and biotic stresses enhance the level of ROS which in turn pose the threat of oxidative stress. Ability to perceive ROS and to speedily commence antioxidant defenses is crucial for the survival as well as longevity of living cells. Therefore living organisms are bestowed with antioxidants to combat the damages caused by oxidative stress. This chapter aims to elucidate an overview of the process of ageing, generation and enhancement of reactive oxygen species, damages incurred by oxidative stress, its amelioration strategies, therapeutic and biotechnological potentials of antioxidants and various sources of bioactive compounds significant in retardation of aging process.

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