scholarly journals Transgenic Mice Expressing a Truncated Form of the High Mobility Group I-C Protein Develop Adiposity and an Abnormally High Prevalence of Lipomas

2000 ◽  
Vol 275 (19) ◽  
pp. 14394-14400 ◽  
Author(s):  
Paola Arlotta ◽  
Albert K.-F. Tai ◽  
Guidalberto Manfioletti ◽  
Charles Clifford ◽  
Gilbert Jay ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
High Mobility ◽  
High Mobility Group ◽  
Truncated Form ◽  
C Protein ◽  
Group I ◽  
High Prevalence

High mobility Group I-C protein in astrocytoma and glioblastoma

2004 ◽  
Vol 200 (9) ◽  
pp. 619-624 ◽  
Author(s):  
Takuya Akai ◽  
Yoshimichi Ueda ◽  
Yasuo Sasagawa ◽  
Tomio Hamada ◽  
Takayasu Date ◽  
...  
Keyword(s):  
High Mobility ◽  
High Mobility Group ◽  
C Protein ◽  
Group I

Comparison of multiple forms of the high mobility group I proteins in rodent and human cells. Identification of the human high mobility group I-C protein

1991 ◽  
Vol 198 (1) ◽  
pp. 211-216 ◽  
Author(s):  
Vincenzo GIANCOTTI ◽  
Antonella BANDIERA ◽  
Emanuele BURATTI ◽  
Alfredo FUSCO ◽  
Roberto MARZARI ◽  
...  
Keyword(s):  
High Mobility ◽  
Human Cells ◽  
High Mobility Group ◽  
Multiple Forms ◽  
C Protein ◽  
Group I

Analysis of high mobility group I(Y) [HMGI(Y)] proteins expression in pancreatic neoplasms

2000 ◽  
Vol 118 (4) ◽  
pp. A271
Author(s):  
Nobutsugu Abe ◽  
Takashi Watanabe ◽  
Masanori Sugiyama ◽  
Yutaka Atomi
Keyword(s):  
Pancreatic Neoplasms ◽  
High Mobility ◽  
High Mobility Group ◽  
Group I

The high mobility group I-C gene (HMGI-C): polymorphism and genetic localization

1996 ◽  
Vol 99 (1) ◽  
pp. 103-105 ◽  
Author(s):  
C. S. Ishwad ◽  
M. D. Shriver ◽  
D. M. Lassige ◽  
R. E. Ferrell
Keyword(s):  
High Mobility ◽  
High Mobility Group ◽  
Genetic Localization ◽  
Group I

scholarly journals L-Sox5 and Sox6 Drive Expression of the Aggrecan Gene in Cartilage by Securing Binding of Sox9 to a Far-Upstream Enhancer

2008 ◽  
Vol 28 (16) ◽  
pp. 4999-5013 ◽  
Author(s):  
Yu Han ◽  
Véronique Lefebvre
Keyword(s):  
Transcription Factor ◽  
Transcription Factors ◽  
Transgenic Mice ◽  
Mode Of Action ◽  
High Mobility ◽  
Recognition Site ◽  
High Mobility Group ◽  
Minimal Promoter ◽  
Chondrocyte Differentiation ◽  
Cartilage Proteoglycan

ABSTRACT The Sry-related high-mobility-group box transcription factor Sox9 recruits the redundant L-Sox5 and Sox6 proteins to effect chondrogenesis, but the mode of action of the trio remains unclear. We identify here a highly conserved 359-bp sequence 10 kb upstream of the Agc1 gene for aggrecan, a most essential cartilage proteoglycan and key marker of chondrocyte differentiation. This sequence directs expression of a minimal promoter in both embryonic and adult cartilage in transgenic mice, in a manner that matches Agc1 expression. The chondrogenic trio is required and sufficient to mediate the activity of this enhancer. It acts directly, Sox9 binding to a critical cis-acting element and L-Sox5/Sox6 binding to three additional elements, which are cooperatively needed. Upon binding to their specific sites, L-Sox5/Sox6 increases the efficiency of Sox9 binding to its own recognition site and thereby robustly potentiates the ability of Sox9 to activate the enhancer. L-Sox5/Sox6 similarly secures Sox9 binding to Col2a1 (encoding collagen-2) and other cartilage-specific enhancers. This study thus uncovers critical cis-acting elements and transcription factors driving Agc1 expression in cartilage and increases understanding of the mode of action of the chondrogenic Sox trio.

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