scholarly journals The Life Span Determinant p66Shc Localizes to Mitochondria Where It Associates with Mitochondrial Heat Shock Protein 70 and Regulates Trans-membrane Potential

2004 ◽  
Vol 279 (24) ◽  
pp. 25689-25695 ◽  
Author(s):  
Francesca Orsini ◽  
Enrica Migliaccio ◽  
Maurizio Moroni ◽  
Cristina Contursi ◽  
Veronica A. Raker ◽  
...  
Keyword(s):  
Membrane Potential ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Life Span ◽  
Heat Shock Protein 70 ◽  
Mitochondrial Heat Shock Protein

scholarly journals Overexpression of Mitochondrial Hsp70/Hsp75 Protects Astrocytes against Ischemic Injury in vitro

2007 ◽  
Vol 28 (5) ◽  
pp. 1009-1016 ◽  
Author(s):  
Ludmila A Voloboueva ◽  
Melissa Duan ◽  
YiBing Ouyang ◽  
John F Emery ◽  
Christian Stoy ◽  
...  
Keyword(s):  
Membrane Potential ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Mitochondrial Membrane Potential ◽  
Heat Shock Protein 70 ◽  
Mitochondrial Membrane ◽  
Ischemic Injury ◽  
Glucose Deprivation ◽  
Hsp70 Family

Mitochondrial heat shock protein 70 (mtHsp70/Hsp75/Grp75/mortalin/TRAP-1/PBP74) is an essential mitochondrial chaperone and a member of the heat shock protein 70 (HSP70) family. Although many studies have shown the protective properties of overexpression of the cytosolic inducible member of the HSP70 family, Hsp72, few studies have investigated the protective potential of Hsp75 against ischemic injury. Mitochondria are one of the primary targets of ischemic injury in astrocytes. In this study, we analyzed the effects of Hsp75 overexpression on cellular levels of reactive oxygen species (ROS), mitochondrial membrane potential, ATP levels, and viability during the ischemia-like conditions of oxygen-glucose deprivation (OGD) or glucose deprivation (GD) in primary astrocytic cultures. We show that Hsp75 overexpression decreases ROS production and preserves mitochondrial membrane potential during GD, and preserves ATP levels and cell viability during OGD. These findings indicate that Hsp75 can provide protection against ischemia-like in vitro injury and suggest that it should be further studied as a potential candidate for protection against ischemic injury.

Characterization and expression analysis of a mitochondrial heat-shock protein 70 gene from the Antarctic moss Pohlia nutans

Polar Biology ◽  
2014 ◽  
Vol 37 (8) ◽  
pp. 1145-1155 ◽  
Author(s):  
Shenghao Liu ◽  
Jing Wang ◽  
Bailin Cong ◽  
Xiaohang Huang ◽  
Kaoshan Chen ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Expression Analysis ◽  
Heat Shock Protein 70 ◽  
Mitochondrial Heat Shock Protein ◽  
The Antarctic ◽  
Pohlia Nutans ◽  
Antarctic Moss

scholarly journals Mitochondrial heat shock protein 70, a molecular chaperone for proteins encoded by mitochondrial DNA.

1994 ◽  
Vol 127 (4) ◽  
pp. 893-902 ◽  
Author(s):  
J M Herrmann ◽  
R A Stuart ◽  
E A Craig ◽  
W Neupert
Keyword(s):  
Mitochondrial Dna ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Critical Role ◽  
Molecular Complexes ◽  
Mitochondrial Ribosomes ◽  
Mitochondrial Heat Shock Protein

Mitochondrial heat shock protein 70 (mt-Hsp70) has been shown to play an important role in facilitating import into, as well as folding and assembly of nuclear-encoded proteins in the mitochondrial matrix. Here, we describe a role for mt-Hsp70 in chaperoning proteins encoded by mitochondrial DNA and synthesized within mitochondria. The availability of mt-Hsp70 function influences the pattern of proteins synthesized in mitochondria of yeast both in vivo and in vitro. In particular, we show that mt-Hsp70 acts in maintaining the var1 protein, the only mitochondrially encoded subunit of mitochondrial ribosomes, in an assembly competent state, especially under heat stress conditions. Furthermore, mt-Hsp70 helps to facilitate assembly of mitochondrially encoded subunits of the ATP synthase complex. By interacting with the ATP-ase 9 oligomer, mt-Hsp70 promotes assembly of ATP-ase 6, and thereby protects the latter protein from proteolytic degradation. Thus mt-Hsp70 by acting as a chaperone for proteins encoded by the mitochondrial DNA, has a critical role in the assembly of supra-molecular complexes.

scholarly journals Relationship between heat shock protein 70 expression and life span in Daphnia

2014 ◽  
Vol 139 ◽  
pp. 1-10 ◽  
Author(s):  
Charles Schumpert ◽  
Indhira Handy ◽  
Jeffry L. Dudycha ◽  
Rekha C. Patel
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Life Span ◽  
Heat Shock Protein 70
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