scholarly journals Hsp27 Regulates Akt Activation and Polymorphonuclear Leukocyte Apoptosis by Scaffolding MK2 to Akt Signal Complex

2007 ◽  
Vol 282 (30) ◽  
pp. 21598-21608 ◽  
Author(s):  
Rui Wu ◽  
Hina Kausar ◽  
Paul Johnson ◽  
Diego E. Montoya-Durango ◽  
Michael Merchant ◽  
...  
Keyword(s):  
Polymorphonuclear Leukocyte ◽  
Akt Activation ◽  
Leukocyte Apoptosis

Modulation of Polymorphonuclear Leukocyte Apoptosis in the Critically Ill by Removal of Cytokines with Continuous Hemodiafiltration

2004 ◽  
Vol 22 (2) ◽  
pp. 188-197 ◽  
Author(s):  
Takeshi Hirano ◽  
Hiroyuki Hirasawa ◽  
Shigeto Oda ◽  
Hidetoshi Shiga ◽  
Kazuya Nakanishi ◽  
...  
Keyword(s):  
Critically Ill ◽  
Polymorphonuclear Leukocyte ◽  
Continuous Hemodiafiltration ◽  
Leukocyte Apoptosis

scholarly journals Polymorphonuclear Leukocyte Apoptosis Is Accelerated by Sulfatides or Sulfatides-TreatedSalmonellaTyphimurium Bacteria

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Zoryana V. Grishina ◽  
Galina M. Viryasova ◽  
Yulia M. Romanova ◽  
Galina F. Sud’ina
Keyword(s):  
Flow Cytometry ◽  
Polymorphonuclear Leukocyte ◽  
Human Neutrophil ◽  
Apoptotic Index ◽  
Neutrophil Apoptosis ◽  
Apoptotic Cells ◽  
Galactosidase Activity ◽  
Leukocyte Apoptosis ◽  
Intracellular Compartments ◽  
Ceramide Content

Neutrophils die by apoptosis following activation and uptake of microbes or enter apoptosis spontaneously at the end of their lifespan if they do not encounter a pathogen. Here we report that sulfatides or sulfatides-treatedSalmonellaTyphimurium bacteria accelerated human neutrophil apoptosis. Neutrophil apoptosis was examined by flow cytometry. Sulfatides caused prominent increase in percentage of apoptotic cells after 2.5 hrs of incubation.SalmonellaTyphimurium bacteria by themselves did not affect the basal level of apoptosis in neutrophil population. When neutrophils were added toS.Typhimurium “opsonized” by sulfatides, apoptotic index significantly increased, whereas the number of phagocyting cells was not influenced. Sulfatides’ proapoptotic effect was strongly dependent on the activity ofβ-galactosidase; inhibition of this enzyme impaired its potency to accelerate apoptosis. These data support the mechanism of neutrophil apoptosis triggering based on sulfatides’ ability to accumulate in intracellular compartments and mediate successive increase in ceramide content resulting fromβ-galactosidase activity.

scholarly journals Alkaline Conditions Accelerate Polymorphonuclear Leukocyte Apoptosis In Vitro

1999 ◽  
Vol 67 (4) ◽  
pp. 2019-2021 ◽  
Author(s):  
Binnaz Leblebicioglu ◽  
John Walters
Keyword(s):  
Polymorphonuclear Leukocyte ◽  
Serine Proteases ◽  
Polymorphonuclear Leukocytes ◽  
Caspase 3 ◽  
Leukocyte Apoptosis ◽  
Caspase 1 ◽  
Alkaline Conditions

ABSTRACT Apoptosis was monitored in polymorphonuclear leukocytes (PMNs) cultured under mildly acidic, neutral, and alkaline conditions. Within 3 h, 9.0% of the PMNs underwent apoptosis at pH 6.7, as did 12% at pH 7.2, 38% at pH 7.7, and 60% at pH 8.2. Inhibitors of serine proteases, caspase-1, or caspase-3 significantly inhibited PMN apoptosis at pH 8.2, suggesting an involvement by these enzymes.

Interleukin-8–induced suppression of polymorphonuclear leukocyte apoptosis is mediated by suppressing CD95 (Fas/Apo-1) Fas-l interactions

Surgery ◽  
1998 ◽  
Vol 124 (2) ◽  
pp. 409-417 ◽  
Author(s):  
Stephanie Leuenroth ◽  
Christine Lee ◽  
Patricia Grutkoski ◽  
Hugh Keeping ◽  
H.Hank Simms
Keyword(s):  
Polymorphonuclear Leukocyte ◽  
Interleukin 8 ◽  
Leukocyte Apoptosis ◽  
Fas L

CHELERYTHRINE CHLORIDE INDUCES RAPID POLYMORPHONUCLEAR LEUKOCYTE APOPTOSIS THROUGH ACTIVATION OF CASPASE-3

Shock ◽  
2000 ◽  
Vol 13 (6) ◽  
pp. 464-471 ◽  
Author(s):  
John F. Sweeney ◽  
Phu Kim Nguyen ◽  
Kevin B. Atkins ◽  
Daniel B. Hinshaw
Keyword(s):  
Polymorphonuclear Leukocyte ◽  
Caspase 3 ◽  
Leukocyte Apoptosis ◽  
Chelerythrine Chloride

Platelet Metabolism during the Interiorization of Two Different Types of Particulate Matter

1972 ◽  
Vol 27 (02) ◽  
pp. 263-271 ◽  
Author(s):  
I. A. Cooper ◽  
P Cochrane ◽  
B. G. Firkin ◽  
K. J. Pinkard
Keyword(s):  
Particulate Matter ◽  
Polymorphonuclear Leukocyte ◽  
Anaerobic Metabolism ◽  
Human Platelets ◽  
Metabolic Changes ◽  
Polystyrene Latex ◽  
Considerable Time ◽  
Difference Of Opinion ◽  
Different Types ◽  
Aerobic And Anaerobic

SummaryIt has been suggested that human platelets possess the ability to phagocytose particulate matter similar to the polymorphonuclear leukocyte. However some difference of opinion has arisen regarding this contention, particularly as differences have been demonstrated with regard to the observed metabolic changes occurring in platelets related to such a process.The experiments reported in this paper were designed to observe the aerobic and anaerobic metabolism in human platelets during and following interiorization of two different particles, viz. polystyrene latex and thorotrast. The results of these experiments show a marked difference between both types of particles with regard to observable metabolic changes despite the rapid interiorization of both types of material. Some alteration occurs in both aerobic and anaerobic metabolism a considerable time after interiorization of latex, whereas no alteration could be demonstrated after interiorization of thorotrast. It is suggested that the interiorization of particulate matter is by some process other than phagocytosis and that observed metabolic changes related to latex may be due to a release reaction.

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