Heparan sulfate antagonism alters bone morphogenetic protein signaling and receptor dynamics, suggesting a mechanism in hereditary multiple exostoses

Christina Mundy; Evan Yang; Hajime Takano; Paul C. Billings; Maurizio Pacifici

doi:10.1074/jbc.ra117.000264

Heparan sulfate antagonism alters bone morphogenetic protein signaling and receptor dynamics, suggesting a mechanism in hereditary multiple exostoses

Journal of Biological Chemistry ◽

10.1074/jbc.ra117.000264 ◽

2018 ◽

Vol 293 (20) ◽

pp. 7703-7716 ◽

Cited By ~ 6

Author(s):

Christina Mundy ◽

Evan Yang ◽

Hajime Takano ◽

Paul C. Billings ◽

Maurizio Pacifici

Keyword(s):

Heparan Sulfate ◽

Bone Morphogenetic Protein ◽

Protein Signaling ◽

Bone Morphogenetic Protein Signaling ◽

Hereditary Multiple Exostoses ◽

Morphogenetic Protein ◽

Multiple Exostoses ◽

Receptor Dynamics

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Cell-surface Heparan Sulfate Proteoglycans Potentiate Chordin Antagonism of Bone Morphogenetic Protein Signaling and Are Necessary for Cellular Uptake of Chordin

Journal of Biological Chemistry ◽

10.1074/jbc.m408129200 ◽

2004 ◽

Vol 279 (49) ◽

pp. 51289-51297 ◽

Cited By ~ 52

Author(s):

Reema Jasuja ◽

Benjamin L. Allen ◽

William N. Pappano ◽

Alan C. Rapraeger ◽

Daniel S. Greenspan

Keyword(s):

Cell Surface ◽

Heparan Sulfate ◽

Bone Morphogenetic Protein ◽

Cellular Uptake ◽

Heparan Sulfate Proteoglycans ◽

Protein Signaling ◽

Bone Morphogenetic Protein Signaling ◽

Morphogenetic Protein

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Heparan sulfate deficiency leads to hypertrophic chondrocytes by increasing bone morphogenetic protein signaling

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2020.08.003 ◽

2020 ◽

Vol 28 (11) ◽

pp. 1459-1470

Author(s):

K. Kawashima ◽

H. Ogawa ◽

S. Komura ◽

T. Ishihara ◽

Y. Yamaguchi ◽

...

Keyword(s):

Heparan Sulfate ◽

Bone Morphogenetic Protein ◽

Hypertrophic Chondrocytes ◽

Protein Signaling ◽

Bone Morphogenetic Protein Signaling ◽

Morphogenetic Protein

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Apoptosis in Membranous Bone Formation: Role of Fibroblast Growth Factor and Bone Morphogenetic Protein Signaling

Critical Reviews in Eukaryotic Gene Expression ◽

10.1615/critreveukaryotgeneexpr.v15.i1.50 ◽

2005 ◽

Vol 15 (1) ◽

pp. 75-92 ◽

Cited By ~ 11

Author(s):

Olivia Fromigue ◽

Dominique Modrowski ◽

Pierre J. Marie

Keyword(s):

Growth Factor ◽

Bone Formation ◽

Fibroblast Growth Factor ◽

Bone Morphogenetic Protein ◽

Fibroblast Growth ◽

Protein Signaling ◽

Bone Morphogenetic Protein Signaling ◽

Morphogenetic Protein

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Faculty Opinions recommendation of Bone morphogenetic protein signaling enhances invasion and bone metastasis of breast cancer cells through Smad pathway.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1123878.580978 ◽

2008 ◽

Author(s):

Robert Sikes

Keyword(s):

Breast Cancer ◽

Bone Metastasis ◽

Cancer Cells ◽

Bone Morphogenetic Protein ◽

Breast Cancer Cells ◽

Protein Signaling ◽

Bone Morphogenetic Protein Signaling ◽

Smad Pathway ◽

Morphogenetic Protein

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Dysregulated Bone Morphogenetic Protein Signaling in Monocrotaline-Induced Pulmonary Arterial Hypertension

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvbaha.107.141200 ◽

2007 ◽

Vol 27 (5) ◽

pp. 1072-1078 ◽

Cited By ~ 97

Author(s):

Rory E. Morty ◽

Bozena Nejman ◽

Grazyna Kwapiszewska ◽

Matthias Hecker ◽

Anka Zakrzewicz ◽

...

Keyword(s):

Pulmonary Arterial Hypertension ◽

Arterial Hypertension ◽

Bone Morphogenetic Protein ◽

Protein Signaling ◽

Bone Morphogenetic Protein Signaling ◽

Morphogenetic Protein ◽

Pulmonary Arterial

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von Willebrand Factor Type C Domain-containing Proteins Regulate Bone Morphogenetic Protein Signaling through Different Recognition Mechanisms

Journal of Biological Chemistry ◽

10.1074/jbc.m700456200 ◽

2007 ◽

Vol 282 (27) ◽

pp. 20002-20014 ◽

Cited By ~ 72

Author(s):

Jin-Li Zhang ◽

Yi Huang ◽

Li-Yan Qiu ◽

Joachim Nickel ◽

Walter Sebald

Keyword(s):

Bone Morphogenetic Protein ◽

Von Willebrand Factor ◽

Protein Signaling ◽

Bone Morphogenetic Protein Signaling ◽

Morphogenetic Protein ◽

Type C ◽

Factor Type ◽

Von Willebrand ◽

Willebrand Factor

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Bone morphogenetic protein signaling governs biliary‐driven liver regeneration in zebrafish through tbx2b and id2a

Hepatology ◽

10.1002/hep.29309 ◽

2017 ◽

Vol 66 (5) ◽

pp. 1616-1630 ◽

Cited By ~ 13

Author(s):

Tae‐Young Choi ◽

Mehwish Khaliq ◽

Shinya Tsurusaki ◽

Nikolay Ninov ◽

Didier Y.R. Stainier ◽

...

Keyword(s):

Liver Regeneration ◽

Bone Morphogenetic Protein ◽

Protein Signaling ◽

Bone Morphogenetic Protein Signaling ◽

Morphogenetic Protein

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Genetic Analyses Demonstrate That Bone Morphogenetic Protein Signaling Is Required for Embryonic Cerebellar Development

Journal of Neuroscience ◽

10.1523/jneurosci.3202-05.2006 ◽

2006 ◽

Vol 26 (7) ◽

pp. 1896-1905 ◽

Cited By ~ 37

Author(s):

L. Qin

Keyword(s):

Bone Morphogenetic Protein ◽

Cerebellar Development ◽

Protein Signaling ◽

Bone Morphogenetic Protein Signaling ◽

Genetic Analyses ◽

Morphogenetic Protein

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Protein Serine/Threonine Phosphatase PPM1A Dephosphorylates Smad1 in the Bone Morphogenetic Protein Signaling Pathway

Journal of Biological Chemistry ◽

10.1074/jbc.m605169200 ◽

2006 ◽

Vol 281 (48) ◽

pp. 36526-36532 ◽

Cited By ~ 73

Author(s):

Xueyan Duan ◽

Yao-Yun Liang ◽

Xin-Hua Feng ◽

Xia Lin

Keyword(s):

Bone Morphogenetic Protein ◽

Signaling Pathway ◽

Protein Signaling ◽

Bone Morphogenetic Protein Signaling ◽

Morphogenetic Protein

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Smad9 is a new type of transcriptional regulator in bone morphogenetic protein signaling

Scientific Reports ◽

10.1038/srep07596 ◽

2014 ◽

Vol 4 (1) ◽

Cited By ~ 44

Author(s):

S. Tsukamoto ◽

T. Mizuta ◽

M. Fujimoto ◽

S. Ohte ◽

K. Osawa ◽

...

Keyword(s):

Bone Morphogenetic Protein ◽

Transcriptional Regulator ◽

Protein Signaling ◽

Bone Morphogenetic Protein Signaling ◽

Morphogenetic Protein ◽

New Type

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